RESUMO
An unprecedented oxidative cross-esterification in an equimolar mixture of dithiolanes, alcohols and water through a CDC/deprotection sequence has been developed. The reaction itself features simple experimental procedures under very mild conditions and offers a new strategic protocol for the direct and efficient synthesis of structurally diverse esters.
Assuntos
Álcoois/química , Hidrogênio/química , Enxofre/química , Esterificação , OxirreduçãoRESUMO
A series of chiral pyrrolidinyl-sulfamide derivatives have been identified as efficient bifunctional organocatalysts for the direct Michael addition of cyclohexanone to a wide range of nitroalkenes. The desired Michael adducts were obtained in high chemical yields and excellent stereoselectivities (up to 99/1 dr and 95% ee).
Assuntos
Alcenos/química , Cicloexanonas/química , Nitroparafinas/síntese química , Pirrolidinas/química , Sulfonamidas/química , Catálise , Estrutura Molecular , Nitroparafinas/química , EstereoisomerismoRESUMO
An efficient and general approach to oxazino[4,3-a]indole architectures is described. The addition-cyclization cascade of (1H-indol-2-yl)methanols with vinyl sulfonium salts affords oxazino[4,3-a]indole derivatives in high yields.