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Nat Prod Res ; 35(5): 845-848, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30990332

RESUMO

The fresh aerial parts of Thymus willdenowii Boiss. & Reut. (syn. Thymus hirtus Willd.) were hydrodistilled in a Clevenger type apparatus and analyzed by GC and GC-MS. 44 Components were identified representing 97.3%, with 1,8-cineole (34.62%), camphor (18.55%), α-pinene (9.46%) and camphene (5.38%) as the main components. T. willdenowii essential oil was not cytotoxic (CC50 = 97.65 µg/mL) towards Vero non-tumoural cells, exhibiting good antibacterial and antiproliferative (30.8 ± 3.1% inhibition) potentials against four tested pathogenic bacteria and Human colorectal cell line HT-29, respectively. The essential oil did not show a DPPH radical scavenging activity, by Electron Spin Resonance spectroscopy (ESR), and it lacks antiviral effect towards coxsackievirus B3.


Assuntos
Óleos Voláteis/química , Óleos Voláteis/farmacologia , Thymus (Planta)/química , Antibacterianos/farmacologia , Antioxidantes/farmacologia , Antivirais/farmacologia , Monoterpenos Bicíclicos/farmacologia , Cânfora/farmacologia , Proliferação de Células/efeitos dos fármacos , Células HT29 , Humanos , Testes de Sensibilidade Microbiana
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