1.
Angew Chem Int Ed Engl
; 62(49): e202310583, 2023 Dec 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37850515
RESUMO
Anilines are potentially high-value arylating agents, but are limited by the low reactivity of the strong C-N bond. We show that the reactive intermediate benzyne can be used to both activate anilines, and set-up an aryl transfer reaction in a single step. The reaction does not require any transition metal catalysts or stoichiometric organometallics, and establishes a metal-free route to valuable biaryl products by functionalizing the aniline C-N bond.
2.
Chem Sci
; 11(17): 4439-4443, 2020 Apr 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34122900
RESUMO
A ruthenium-catalyzed ortho C-H arylation process is described using visible light. Using the readily available catalyst [RuCl2(p-cymene)]2, visible light irradiation was found to enable arylation of 2-aryl-pyridines at room temperature for a range of aryl bromides and iodides.