1.
Chem Commun (Camb)
; 54(15): 1897-1900, 2018 Feb 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29393312
RESUMO
Here, we report on the in vitro binding properties of the known pyridine dicarboxamide G-quadruplex ligand 360A and a new dimeric analogue (360A)2A to human telomeric DNA higher-order G-quadruplex (G4) structures. This study points to original binding features never reported for G4 ligands, and reveals a greater efficiency for the dimeric ligand to displace RPA (a ssDNA binding protein involved in telomere replication) from telomeric DNA.