RESUMO
We report a patient with plexiform neurofibroma, which is pathognomonic for neurofibromatosis type 1 (NF1) affecting the upper parietal region of the scalp. Cerebellar hamartoma was present, a finding that, to our knowledge, has not been reported previously. We highlight the role of histopathology, ultrasonography, colour Doppler imaging and magnetic resonance imaging, in addition to the seven existing criteria, for the diagnosis of NF1.
Assuntos
Doenças Cerebelares/diagnóstico , Hamartoma/diagnóstico , Neurofibroma Plexiforme/diagnóstico , Dermatoses do Couro Cabeludo/diagnóstico , Adulto , Doenças Cerebelares/patologia , Ecocardiografia Doppler em Cores , Feminino , Hamartoma/patologia , Humanos , Imageamento por Ressonância Magnética , Neurofibroma Plexiforme/patologia , Dermatoses do Couro Cabeludo/patologia , Adulto JovemRESUMO
1- Most healthy adults are naturally resistant to leprosy. This resistance is increased by small infections, but it is low in young children, and is decreased in debilitated persons and in those who have become hyper infected with Mycobacterium leprae. 2- Evidence in favour of the above is found in the leprolin test, the use of which is explained. 3- Similarity is found between the clinical and histological appearances of a patient's leprous lesions, and those of the nodule produced by the leprolin test when this test is carried out in the same patient. 4- The factors influencing the spread of leprosy are given in diagrammatic form. 5- The histories of six typical leprous families are examined in detail. These tend to confirm the above hypotheses concerning the spread of infection.