Correlation Between Anosmia and Severity Along with Requirement of Tocilizumab in COVID-19 Patients.

Anosmia with or without dysgeusia is frequently associated with Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) SARS-CoV-2 infection. SARS-CoV-2 virus affects the olfactory system and thus represents neurotropic and neuro-invasive nature of the virus. We found that tocilizumab's role in reducing mortality in severe covid-19 infection is still questionable and aim of our study was correlation of anosmia and severity of covid-19 infection and requirement of tocilizumab in anosmia patients. To establish relationship between anosmia and severity of COVID-19 infection along with requirement of tocilizumab. This was a retrospective cum prospective cross sectional study done on COVID-19 patients who were admitted in normal COVID-19 ward and intensive care unit of Employee's State Insurance Corporation Hospital, Udaipur and Maharaja Bhupal Hospital of Ravindra Nath Medical College between September 2020 and 15 January 2021 age group of 18 to 92 years, both sexes. We had asked about anosmia in all COVID-19 positive patients and followed all patients in perspective of severity of disease and tocilizumab. p value < 0.001 of prevalence of anosmia in COVID -19 patients who were isolated at home, admitted in ward and intensive care unit showed that anosmia is inversely related to severity of disease. Tocilizumab has no significant role in decreasing mortality in severe form of disease. Our study indicates that anosmia is related to the mildness of disease and there is no role of tocilizumab in decreasing the mortality in severe form of disease.

Relevance of Nanomaterials in Food Packaging and its Advanced Future Prospects.

Biopolymers have been used in packaged foods to tackle environmental hazards due to their biodegradability and non-toxic nature. In addition to these merits, they have also several demerits such as poor mechanical properties and low resistance towards water. Nanomaterials have attracted great interest in recent years due to their phenomenal properties that makes them precedent in applications for food packaging as they enhance the mechanical, thermal and gas barriers properties, without compromising with the ability to become non-toxic and biodegradable. The most important nanomaterials used in food packaging are montmorillonite (MMT), zinc oxide (ZnO-NPs) coated silicate, kaolinite, silver NPs (Ag-NPs) and titanium dioxide (TiO2NPs) as these, nanomaterials coated films makes a barrier against oxygen, carbon dioxide and favour compounds. They also possess oxygen scavenging capability, antimicrobial activity and tolerance towards temperature. The most difficult task related to the preparation of these nanocomposites is their complete distribution within the polymer matrix and their compatibility. Therefore, there is an increasing demand for improvement in the performance of nano-packaging materials including mechanical stability, degradability and effectiveness of antibacterial property.