Cardiovascular and Self-Regulatory Consequences of SES-Based Social Identity Threat.

This work examined the effects of socioeconomic status (SES)-based social identity threat on cardiovascular indexes of challenge and threat and self-regulatory strength. Participants ( N = 104) took an exam described as either diagnostic of intellectual ability (identity threat) or framed as a problem-solving task (control) while we recorded cardiovascular reactivity and assessed participants' physical self-control. Under identity threat, lower SES students exhibited impaired performance, reduced self-control, and cardiovascular threat reactivity. In contrast, higher SES students under threat exhibited the reverse pattern-a boost in performance, no change in self-regulation, and cardiovascular challenge reactivity. Furthermore, while measures of general arousal (heart rate and pre-ejection period) were unrelated to performance, cardiovascular patterns of challenge and threat were significantly associated with performance under identity threat. Results provide evidence that SES-based stigma influences physiological and self-regulatory processes.

Obesity and Triple-Negative Breast Cancer: Disparities, Controversies, and Biology.

Once considered a problem of Western nations, obesity (body mass index ≥30 kg/m2) has rapidly increased since the 1970s to become a major threat to world health. Since 1970, the face of obesity has changed from a disease of affluence and abundance to a disease of poverty. During the last 10 years, studies have mechanistically linked obesity and an obese tumor microenvironment with signaling pathways that predict aggressive breast cancer biology. For example, in the United States, African American women are more likely than non-Hispanic European American women to be obese and to be diagnosed with triple-negative breast cancer (TNBC). In 2008, the Carolina Breast Study found that obesity (increased waist/hip ratio) was linked to an increased incidence of TNBC in premenopausal and postmenopausal African American women. Subsequently, several groups have investigated the potential link between obesity and TNBC in African American women. To date, the data are complex and sometimes contradictory. We review epidemiologic studies that investigated the potential association among obesity, metabolic syndrome, and TNBC in African American women and mechanistic studies that link insulin signaling to the obese breast microenvironment, tissue inflammation, and aggressive TNBC biology.