Being Heterogeneous Is Advantageous: Extreme Brownian Non-Gaussian Searches.

Redundancy in biology may be explained by the need to optimize extreme searching processes, where one or few among many particles are requested to reach the target like in human fertilization. We show that non-Gaussian rare fluctuations in Brownian diffusion dominates such searches, introducing drastic corrections to the known Gaussian behavior. Our demonstration entails different physical systems and pinpoints the relevance of diversity within redundancy to boost fast targeting. We sketch an experimental context to test our results: polydisperse systems.

Being heterogeneous is disadvantageous: Brownian non-Gaussian searches.

Diffusing diffusivity models, polymers in the grand canonical ensemble and polydisperse, and continuous-time random walks all exhibit stages of non-Gaussian diffusion. Is non-Gaussian targeting more efficient than Gaussian? We address this question, central to, e.g., diffusion-limited reactions and some biological processes, through a general approach that makes use of Jensen's inequality and that encompasses all these systems. In terms of customary mean first-passage time, we show that Gaussian searches are more effective than non-Gaussian ones. A companion paper argues that non-Gaussianity becomes instead highly more efficient in applications where only a small fraction of tracers is required to reach the target.

Erratum: "Fractional Brownian motion with random Hurst exponent: Accelerating diffusion and persistence transitions" [Chaos 32, 093114 (2022)].

We point out a minor mistake in Fig. 10 in the published version of our paper [M. Balcerek et al., Chaos 32, 093114 (2022)]. The conclusions drawn from the illustration remain the same.

Negative diffusion of excitons in quasi-two-dimensional systems.

We show how two different mobile-immobile type models explain the observation of negative diffusion of excitons reported in experimental studies in quasi-two-dimensional semiconductor systems. The main reason for the effect is the initial trapping and a delayed release of free excitons in the area close to the original excitation spot. The density of trapped excitons is not registered experimentally. Hence, the signal from the free excitons alone includes the delayed release of not diffusing trapped particles. This is seen as the narrowing of the exciton density profile or decrease of mean-squared displacement which is then interpreted as a negative diffusion. The effect is enhanced with the increase of recombination intensity as well as the rate of the exciton-exciton binary interactions.

Role of asymmetry and external noise in the development and synchronization of oscillations in the analog Hopfield neural networks with time delay.

The analog Hopfield neural network with time delay and random connections has been studied for its similarities in activity to human electroencephalogram and its usefulness in other areas of the applied sciences such as speech recognition, image analysis, and electrocardiogram modeling. Our goal here is to understand the mechanisms that affect the rhythmic activity in the neural network and how the addition of a Gaussian noise contributes to the network behavior. The neural network studied is composed of ten identical neurons. We investigated the excitatory and inhibitory networks with symmetric (square matrix) and asymmetric (triangular matrix) connections. The differential equations that model the network are solved numerically using the stochastic second-order Runge-Kutta method. Without noise, the neural networks with symmetric and asymmetric matrices possessed different synchronization properties: fully connected networks were synchronized both in time and in amplitude, while asymmetric networks were synchronized in time only. Saturation outputs of the excitatory neural networks do not depend on the time delay, whereas saturation oscillation amplitudes of inhibitory networks increase with the time delay until the steady state. The addition of the Gaussian noise is shown to significantly amplify small-amplitude oscillations, dramatically accelerates the rate of amplitude growth to saturation, and changes synchronization properties of the neural network outputs.

Time-fractional Caputo derivative versus other integrodifferential operators in generalized Fokker-Planck and generalized Langevin equations.

Fractional diffusion and Fokker-Planck equations are widely used tools to describe anomalous diffusion in a large variety of complex systems. The equivalent formulations in terms of Caputo or Riemann-Liouville fractional derivatives can be derived as continuum limits of continuous-time random walks and are associated with the Mittag-Leffler relaxation of Fourier modes, interpolating between a short-time stretched exponential and a long-time inverse power-law scaling. More recently, a number of other integrodifferential operators have been proposed, including the Caputo-Fabrizio and Atangana-Baleanu forms. Moreover, the conformable derivative has been introduced. We study here the dynamics of the associated generalized Fokker-Planck equations from the perspective of the moments, the time-averaged mean-squared displacements, and the autocovariance functions. We also study generalized Langevin equations based on these generalized operators. The differences between the Fokker-Planck and Langevin equations with different integrodifferential operators are discussed and compared with the dynamic behavior of established models of scaled Brownian motion and fractional Brownian motion. We demonstrate that the integrodifferential operators with exponential and Mittag-Leffler kernels are not suitable to be introduced to Fokker-Planck and Langevin equations for the physically relevant diffusion scenarios discussed in our paper. The conformable and Caputo Langevin equations are unveiled to share similar properties with scaled and fractional Brownian motion, respectively.

Universal singularities of anomalous diffusion in the Richardson class.

Inhomogeneous environments are rather ubiquitous in nature, often implying anomalies resulting in deviation from Gaussianity of diffusion processes. While sub- and superdiffusion are usually due to contrasting environmental features (hindering or favoring the motion, respectively), they are both observed in systems ranging from the micro- to the cosmological scale. Here we show how a model encompassing sub- and superdiffusion in an inhomogeneous environment exhibits a critical singularity in the normalized generator of the cumulants. The singularity originates directly and exclusively from the asymptotics of the non-Gaussian scaling function of displacement, and the independence from other details confers it a universal character. Our analysis, based on the method first applied by Stella et al. [Phys. Rev. Lett. 130, 207104 (2023)10.1103/PhysRevLett.130.207104], shows that the relation connecting the scaling function asymptotics to the diffusion exponent characteristic of processes in the Richardson class implies a nonstandard extensivity in time of the cumulant generator. Numerical tests fully confirm the results.

Anomalous Dynamical Scaling Determines Universal Critical Singularities.

Anomalous diffusion phenomena occur on length scales spanning from intracellular to astrophysical ranges. A specific form of decay at a large argument of the probability density function of rescaled displacement (scaling function) is derived and shown to imply universal singularities in the normalized cumulant generator. Exact calculations for continuous time random walks provide paradigmatic examples connected with singularities of second order phase transitions. In the biased case scaling is restricted to displacements in the drift direction and singularities have no equilibrium analogue.

Fractional Brownian motion with random Hurst exponent: Accelerating diffusion and persistence transitions.

Fractional Brownian motion, a Gaussian non-Markovian self-similar process with stationary long-correlated increments, has been identified to give rise to the anomalous diffusion behavior in a great variety of physical systems. The correlation and diffusion properties of this random motion are fully characterized by its index of self-similarity or the Hurst exponent. However, recent single-particle tracking experiments in biological cells revealed highly complicated anomalous diffusion phenomena that cannot be attributed to a class of self-similar random processes. Inspired by these observations, we here study the process that preserves the properties of the fractional Brownian motion at a single trajectory level; however, the Hurst index randomly changes from trajectory to trajectory. We provide a general mathematical framework for analytical, numerical, and statistical analysis of the fractional Brownian motion with the random Hurst exponent. The explicit formulas for probability density function, mean-squared displacement, and autocovariance function of the increments are presented for three generic distributions of the Hurst exponent, namely, two-point, uniform, and beta distributions. The important features of the process studied here are accelerating diffusion and persistence transition, which we demonstrate analytically and numerically.

Apparent anomalous diffusion and non-Gaussian distributions in a simple mobile-immobile transport model with Poissonian switching.

We analyse mobile-immobile transport of particles that switch between the mobile and immobile phases with finite rates. Despite this seemingly simple assumption of Poissonian switching, we unveil a rich transport dynamics including significant transient anomalous diffusion and non-Gaussian displacement distributions. Our discussion is based on experimental parameters for tau proteins in neuronal cells, but the results obtained here are expected to be of relevance for a broad class of processes in complex systems. Specifically, we obtain that, when the mean binding time is significantly longer than the mean mobile time, transient anomalous diffusion is observed at short and intermediate time scales, with a strong dependence on the fraction of initially mobile and immobile particles. We unveil a Laplace distribution of particle displacements at relevant intermediate time scales. For any initial fraction of mobile particles, the respective mean squared displacement (MSD) displays a plateau. Moreover, we demonstrate a short-time cubic time dependence of the MSD for immobile tracers when initially all particles are immobile.

Non-Markovian diffusion of excitons in layered perovskites and transition metal dichalcogenides.

The diffusion of excitons in perovskites and transition metal dichalcogenides shows clear anomalous, subdiffusive behaviour in experiments. In this paper we develop a non-Markovian mobile-immobile model which provides an explanation of this behaviour through paired theoretical and simulation approaches. The simulation model is based on a random walk on a 2D lattice with randomly distributed deep traps such that the trapping time distribution involves slowly decaying power-law asymptotics. The theoretical model uses coupled diffusion and rate equations for free and trapped excitons, respectively, with an integral term responsible for trapping. The model provides a good fitting of the experimental data, thus, showing a way for quantifying the exciton diffusion dynamics.

Anomalous diffusion and asymmetric tempering memory in neutrophil chemotaxis.

The motility of neutrophils and their ability to sense and to react to chemoattractants in their environment are of central importance for the innate immunity. Neutrophils are guided towards sites of inflammation following the activation of G-protein coupled chemoattractant receptors such as CXCR2 whose signaling strongly depends on the activity of Ca2+ permeable TRPC6 channels. It is the aim of this study to analyze data sets obtained in vitro (murine neutrophils) and in vivo (zebrafish neutrophils) with a stochastic mathematical model to gain deeper insight into the underlying mechanisms. The model is based on the analysis of trajectories of individual neutrophils. Bayesian data analysis, including the covariances of positions for fractional Brownian motion as well as for exponentially and power-law tempered model variants, allows the estimation of parameters and model selection. Our model-based analysis reveals that wildtype neutrophils show pure superdiffusive fractional Brownian motion. This so-called anomalous dynamics is characterized by temporal long-range correlations for the movement into the direction of the chemotactic CXCL1 gradient. Pure superdiffusion is absent vertically to this gradient. This points to an asymmetric 'memory' of the migratory machinery, which is found both in vitro and in vivo. CXCR2 blockade and TRPC6-knockout cause tempering of temporal correlations in the chemotactic gradient. This can be interpreted as a progressive loss of memory, which leads to a marked reduction of chemotaxis and search efficiency of neutrophils. In summary, our findings indicate that spatially differential regulation of anomalous dynamics appears to play a central role in guiding efficient chemotactic behavior.

Erratum: Rate equations, spatial moments, and concentration profiles for mobile-immobile models with power-law and mixed waiting time distributions [Phys. Rev. E 105, 014105 (2022)].

This corrects the article DOI: 10.1103/PhysRevE.105.014105.

Rate equations, spatial moments, and concentration profiles for mobile-immobile models with power-law and mixed waiting time distributions.

We present a framework for systems in which diffusion-advection transport of a tracer substance in a mobile zone is interrupted by trapping in an immobile zone. Our model unifies different model approaches based on distributed-order diffusion equations, exciton diffusion rate models, and random-walk models for multirate mobile-immobile mass transport. We study various forms for the trapping time dynamics and their effects on the tracer mass in the mobile zone. Moreover, we find the associated breakthrough curves, the tracer density at a fixed point in space as a function of time, and the mobile and immobile concentration profiles and the respective moments of the transport. Specifically, we derive explicit forms for the anomalous transport dynamics and an asymptotic power-law decay of the mobile mass for a Mittag-Leffler trapping time distribution. In our analysis we point out that even for exponential trapping time densities, transient anomalous transport is observed. Our results have direct applications in geophysical contexts, but also in biological, soft matter, and solid state systems.

Stochastic resetting by a random amplitude.

Stochastic resetting, a diffusive process whose amplitude is reset to the origin at random times, is a vividly studied strategy to optimize encounter dynamics, e.g., in chemical reactions. Here we generalize the resetting step by introducing a random resetting amplitude such that the diffusing particle may be only partially reset towards the trajectory origin or even overshoot the origin in a resetting step. We introduce different scenarios for the random-amplitude stochastic resetting process and discuss the resulting dynamics. Direct applications are geophysical layering (stratigraphy) and population dynamics or financial markets, as well as generic search processes.

Capturing multifractality of pressure fluctuations in thermoacoustic systems using fractional-order derivatives.

The stable operation of a turbulent combustor is not completely silent; instead, there is a background of small amplitude aperiodic acoustic fluctuations known as combustion noise. Pressure fluctuations during this state of combustion noise are multifractal due to the presence of multiple temporal scales that contribute to its dynamics. However, existing models are unable to capture the multifractality in the pressure fluctuations. We conjecture an underlying fractional dynamics for the thermoacoustic system and obtain a fractional-order model for pressure fluctuations. The data from this model has remarkable visual similarity to the experimental data and also has a wide multifractal spectrum during the state of combustion noise. Quantitative similarity with the experimental data in terms of the Hurst exponent and the multifractal spectrum is observed during the state of combustion noise. This model is also able to produce pressure fluctuations that are qualitatively similar to the experimental data acquired during intermittency and thermoacoustic instability. Furthermore, we argue that the fractional dynamics vanish as we approach the state of thermoacoustic instability.

Lévy noise-driven escape from arctangent potential wells.

The escape from a potential well is an archetypal problem in the study of stochastic dynamical systems, representing real-world situations from chemical reactions to leaving an established home range in movement ecology. Concurrently, Lévy noise is a well-established approach to model systems characterized by statistical outliers and diverging higher order moments, ranging from gene expression control to the movement patterns of animals and humans. Here, we study the problem of Lévy noise-driven escape from an almost rectangular, arctangent potential well restricted by two absorbing boundaries, mostly under the action of the Cauchy noise. We unveil analogies of the observed transient dynamics to the general properties of stationary states of Lévy processes in single-well potentials. The first-escape dynamics is shown to exhibit exponential tails. We examine the dependence of the escape on the shape parameters, steepness, and height of the arctangent potential. Finally, we explore in detail the behavior of the probability densities of the first-escape time and the last-hitting point.

Probabilistic properties of detrended fluctuation analysis for Gaussian processes.

Detrended fluctuation analysis (DFA) is one of the most widely used tools for the detection of long-range dependence in time series. Although DFA has found many interesting applications and has been shown to be one of the best performing detrending methods, its probabilistic foundations are still unclear. In this paper, we study probabilistic properties of DFA for Gaussian processes. Our main attention is paid to the distribution of the squared error sum of the detrended process. We use a probabilistic approach to derive general formulas for the expected value and the variance of the squared fluctuation function of DFA for Gaussian processes. We also get analytical results for the expected value of the squared fluctuation function for particular examples of Gaussian processes, such as Gaussian white noise, fractional Gaussian noise, ordinary Brownian motion, and fractional Brownian motion. Our analytical formulas are supported by numerical simulations. The results obtained can serve as a starting point for analyzing the statistical properties of DFA-based estimators for the fluctuation function and long-memory parameter.

Scaled Brownian motion with renewal resetting.

We investigate an intermittent stochastic process in which the diffusive motion with time-dependent diffusion coefficient D(t)∼t^{α-1} with α>0 (scaled Brownian motion) is stochastically reset to its initial position, and starts anew. In the present work we discuss the situation in which the memory on the value of the diffusion coefficient at a resetting time is erased, so that the whole process is a fully renewal one. The situation when the resetting of the coordinate does not affect the diffusion coefficient's time dependence is considered in the other work of this series [A. S. Bodrova et al., Phys. Rev. E 100, 012119 (2019)10.1103/PhysRevE.100.012119]. We show that the properties of the probability densities in such processes (erasing or retaining the memory on the diffusion coefficient) are vastly different. In addition we discuss the first-passage properties of the scaled Brownian motion with renewal resetting and consider the dependence of the efficiency of search on the parameters of the process.

Nonrenewal resetting of scaled Brownian motion.

We investigate an intermittent stochastic process in which diffusive motion with a time-dependent diffusion coefficient, D(t)∼t^{α-1}, α>0 (scaled Brownian motion), is stochastically reset to its initial position and starts anew. The resetting follows a renewal process with either an exponential or a power-law distribution of the waiting times between successive renewals. The resetting events, however, do not affect the time dependence of the diffusion coefficient, so that the whole process appears to be a nonrenewal one. We discuss the mean squared displacement of a particle and the probability density function of its positions in this process. We show that scaled Brownian motion with resetting demonstrates rich behavior whose properties essentially depend on the interplay of the parameters of the resetting process and the particle's displacement infree motion. The motion of particles can remain almost unaffected by resetting but can also get slowed down or even be completely suppressed. Especially interesting are the nonstationary situations in which the mean squared displacement stagnates but the distribution of positions does not tend to any steady state. This behavior is compared to the situation [discussed in the companion paper; A. S. Bodrova et al., Phys. Rev. E 100, 012120 (2019)10.1103/PhysRevE.100.012120] in which the memory of the value of the diffusion coefficient at a resetting time is erased, so that the whole process is a fully renewal one. We show that the properties of the probability densities in such processes (erasing or retaining the memory on the diffusion coefficient) are vastly different.