RESUMO
Herpes ophthalmicus (HO) patients were examined for lipid spectrum of the serum. The tests revealed dyslipidemia (DLE) with a distinctive rise in the levels of total cholesterol (CS), alpha-CS and beta-CS. The severity of the lipidemic shifts correlated with that of the infection. DLE was more marked in recurrent HO. Clinical evidence was consistent with experimental findings. In rabbit models, herpetic keratoconjunctivitis was characterized by pronounced lipidemic alterations correctable with antiherpetic drug furavir. The results are discussed in terms of herpetic infection pathogenesis and its role in the development of atherosclerosis.
Assuntos
Hiperlipidemias/etiologia , Ceratite Herpética/complicações , Ceratoconjuntivite/complicações , Adolescente , Adulto , Animais , Antivirais/uso terapêutico , Modelos Animais de Doenças , Quimioterapia Combinada , Feminino , Humanos , Hiperlipidemias/sangue , Hiperlipidemias/tratamento farmacológico , Ceratite Herpética/sangue , Ceratite Herpética/tratamento farmacológico , Ceratoconjuntivite/sangue , Ceratoconjuntivite/tratamento farmacológico , Lipídeos/sangue , Masculino , CoelhosRESUMO
As a result of herpes simplex virus reactivation with holoxan in rabbit reconvalescents with acute primary herpetic keratoconjunctivitis, the ophthalmic herpes relapse was observed and it was characterized by a more severe and prolonged course with longterm viremia and generalization of the infection. In the survived animals the chronic, recurrent ophthalmic herpes was developed.