RESUMO
Two new pterosin sesquiterpenes, (2S)-13-hydroxypterosin A (1) and (2S,3S)-12-hydroxypterosin Q (2), were isolated from the whole plants of Pteris ensiformis, together with six known compounds. The structures of 1 and 2 were determined through extensive 1D/2D-NMR and MS analyses. Compound 2 exhibited antitubercular activity (MIC 6.25â µg/ml) against Mycobacterium tuberculosis H37 Rv in vitro.
Assuntos
Antituberculosos , Indanos/química , Mycobacterium tuberculosis/efeitos dos fármacos , Extratos Vegetais , Pteris/química , Sesquiterpenos/química , Sesquiterpenos/farmacologia , Antituberculosos/química , Antituberculosos/isolamento & purificação , Antituberculosos/farmacologia , Espectroscopia de Ressonância Magnética , Testes de Sensibilidade Microbiana , Conformação Molecular , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Pteris/metabolismo , Sesquiterpenos/isolamento & purificaçãoRESUMO
Four new labdane-type diterpenoids: hedychicoronarin (1), peroxycoronarin D (2), 7ß-hydroxycalcaratarin A (3), and (E)-7ß-hydroxy-6-oxo-labda-8(17),12-diene-15,16-dial (4), have been isolated from the rhizomes of Hedychium coronarium, together with 13 known compounds (5-17). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 3, 5, 6, and 10 exhibited inhibition (IC50 values ≤4.52 µg/mL) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 3-6, 10, and 11 inhibited fMLP/CB-induced elastase release with IC50 values ≤6.17 µg/mL.
Assuntos
Diterpenos , Superóxidos , Anti-Inflamatórios/farmacologia , Diterpenos/química , Humanos , Neutrófilos/efeitos dos fármacos , Elastase Pancreática , Superóxidos/antagonistas & inibidores , ZingiberaceaeRESUMO
Five new compounds, ailanthamide (1), N-(4-methoxyphenethyl)-N-methylbenzamide (2), (2E,4E)-N-isobutyl-6-oxohepta-2,4-dienamide (3), 4-(4'-hydroxy-3'-methylbutoxy)benzaldehyde (4), and (E)-methyl 4-[4-(3-hydroxypropyl)phenoxy]-2-methylbut-2-enoate (5), and 17 known compounds have been isolated from the stem bark of Zanthoxylum ailanthoides. The structures were determined through spectroscopic and MS analyses. Compounds 1, 3, xanthyletin, decarine, (+)-episesamin, (-)-hinokinin, and evofolin-B exhibited inhibition (IC(50) < or = 5.34 microg/mL) of superoxide anion generation by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (fMLP/CB). Compounds 1, xanthyletin, decarine, and (+)-episesamin also inhibited fMLP/CB-induced elastase release with IC(50) values < or = 5.53 microg/mL.
Assuntos
Amidas/isolamento & purificação , Amidas/farmacologia , Benzamidas/isolamento & purificação , Benzamidas/farmacologia , Derivados de Benzeno/isolamento & purificação , Derivados de Benzeno/farmacologia , Neutrófilos/efeitos dos fármacos , Elastase Pancreática/antagonistas & inibidores , Plantas Medicinais/química , Superóxidos/antagonistas & inibidores , Zanthoxylum/química , 4-Butirolactona/análogos & derivados , 4-Butirolactona/farmacologia , Amidas/química , Benzamidas/química , Derivados de Benzeno/química , Benzodioxóis , Cumarínicos/farmacologia , Dioxóis/farmacologia , Humanos , Concentração Inibidora 50 , Lignanas/farmacologia , Estrutura Molecular , Neutrófilos/metabolismo , Elastase Pancreática/metabolismo , Casca de Planta/química , TaiwanRESUMO
Five new biflavonoids, robustaflavone 7,4',4'''-trimethyl ether, robustaflavone 4',4'''-dimethyl ether, 2,3-dihydroamentoflavone 7,4',7''-trimethyl ether, 2,3-dihydroamentoflavone 7,4'-dimethyl ether, and 2'',3''-dihydroisocryptomerin 7-methyl ether, together with six known compounds have been isolated from the aerial parts of Selaginella delicatula. The structures of these new compounds were determined through spectral analyses. Among the isolates, robustaflavone 4',4'''-dimethyl ether, 2,3-dihydroamentoflavone 7,4'-dimethyl ether, and alpha-tocopheryl quinone exhibited cytotoxicities (ED50 values < 4 microg/mL) against P-388 and/or HT-29 cell lines in vitro.
