Prediction of internal jugular vein catheter length inserted through the posterior approach of the sternocleidomastoid muscle.

This study aimed to determine an equation to estimate the optimal insertion length for catheter placement via the posterior approach of the sternocleidomastoid muscle in cancer patients. This retrospective study included patients with cancer who underwent infusion port implantation surgery in the Oncology Department of the 900th Hospital of Joint Logistic Support Force of the Chinese People Liberation Army from April 2017 to September 2023. Patient height (H), weight (W), chest length (C), and length of the internal jugular vein catheter (L) were collected from medical records. The patients were randomized 7:3 to the training and validation sets. Linear regression analyses were used in the training set to determine formulas to predict catheter length. The formula predictive value was analyzed using the Bland-Altman method in the validation set. This study included 336 patients, with a mean age of 58.27 ±â€…11.70 years, randomized in the training (n = 235) and validation (n = 101) sets. Linear regression analysis revealed that the equations for catheter length relative to H, body mass index (BMI), and C are L = 0.144 × H - 8.258 (R²â€…= 0.608, P < .001), L = -0.103 × B + 17.384 (R²â€…= 0.055, P < .001), and L = 0.477 × C + 1.769 (R²â€…= 0.342, P < .001), respectively. The multivariable linear regression analysis showed that the equation between the length of the catheter and H and C was L = 0.131 × H + 0.086 × C-8.515 (R²â€…= 0.614, P < .001). The Bland-Altman analysis in the validation set showed that the predicted values of internal jugular vein catheter length and the actual values showed good agreement. The optimal L might be determined by simple formulas based on patients H and C.

Readjustment of nodal staging by integrating tumor deposits and positive lymph nodes in patients with stage III colon cancer: a population-based analysis.

Whether tumor deposits (TDs) should be classified as lymph node metastasis or distant metastasis remains controversial. To address this predicament, we conducted this study to identify the predictive value of TDs on the survival of patients diagnosed with stage III colon cancer (CC). 12,904 eligible patients diagnosed with stage III CC between 2010 and 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. The best cutoff point of TD quantity was determined based on the difference in survival. Cox proportional hazards model was employed to perform univariate and multivariate analyses. The Kaplan-Meier method and log-rank test were performed to calculate the differences between overall survival (OS). Our results showed that the number of TDs was a significant prognostic factor in patients with stage III CC (P < 0.0001). We added the number of TDs to the pN stage and devised a new pN stage, there were no significant differences in the survival of npN, except npN2a (P > 0.05). Upon re-staging to the same npN stage, the difference in survival between TDs+ and TDs- disappeared (P > 0.05). The median survival times for N2aTDs > 4 and N2bTDs > 4 were 33 and 37 months, respectively, which were significantly shorter than that of N2TDs- (65 months) and represented the worst survival rates among all groups. In conclusion, the number of TDs indicated a poor prognosis for patients with stage III CC. Incorporating TDs into the pN is feasible to predict prognosis.

Open Reduction for Potentially Reducible Atlantoaxial Dislocation Secondary to Transverse Ligament Laxity in Patients with Rheumatoid Arthritis.

OBJECTIVE: Atlantoaxial dislocation (AAD) is classified into reducible AAD and irreducible AAD (IRAAD). Anterior or posterior releasing followed by occipitocervical/atlantoaxial fusion is often performed for IRAAD, but is technically demanding. This study aimed to evaluate the results of the posterior open reduction technique without releasing the atlantoaxial joint in the treatment of potentially reducible AAD (PRAAD) caused by transverse ligament laxity in patients with rheumatoid arthritis (RA). METHODS: Data from 38 RA patients who experienced PRAAD due to transverse ligament laxity were retrospectively reviewed. They all underwent posterior open reduction and fusion without releasing the atlantoaxial joint. Outcomes were evaluated by using atlantodental interval, modified Japanese Orthopedic Association scores, Nurick grade, Neck Disability Index, and visual analog scale score for neck pain. RESULTS: All the patients achieved solid bone fusion at follow-up. The mean atlantodental interval was reduced to 5.6 ± 0.7 mm and 2.1 ± 0.5 mm after traction and operation, respectively, from a preoperative score of 8.2 ± 0.6 mm (P < 0.05). Compared with the respective preoperative values, the mean modified Japanese Orthopedic Association score and Nurick grade were significantly increased at the final follow-up (both P < 0.05), whereas the Neck Disability Index and visual analog scale score for neck pain were significantly decreased (both P < 0.05). CONCLUSIONS: AAD with partial reduction after skeletal traction for 48 hours should be defined as PRAAD, not IRAAD. Open reduction with a C1-C2 pedicle screw-rod system can be safely and effectively applied in the treatment of PRAAD due to transverse ligament laxity in patients with RA.

TRIM32 triggers ß-catenin signaling through ubiquitylation of AXIN1 to promote inflammatory factor-induced apoptosis of rat nucleus pulposus cells.

The dysregulation of ubiquitin ligase is the cause of many human diseases. Tripartite motif protein 32 (TRIM32) is an E3 ubiquitin ligase whose role in nucleus pulposus (NP) cell apoptosis is unclear. The expression of TRIM family protein and ß-catenin in 40 NP tissue samples was detected by RT-PCR. Interleukin (IL)-1ß or tumor necrosis factor (TNF)-α was used to treat rat NP cells. Knockdown and overexpression of Trim32 were achieved using specific siRNA and recombinant plasmids. Western blotting, RT-PCR, and flow cytometry were used to assess the expression of TRIM32/ß-catenin and the apoptosis rate of NP cells. Coimmunoprecipitation was adopted to analyze the possible interactions between AXIN1 and TRIM32. In clinical samples, TRIM32 expression was of positive relevance with the expression of CTNNB1 (ß-catenin). In vitro, apoptosis of IL-1ß- or TNF-α-treated rat NP cells was induced through upregulated Trim32 expression and activated ß-catenin signaling, whereas Trim32 siRNA and inhibition of ß-catenin reversed the induction effect of cytokines. Further studies indicated that TRIM32 activated the ß-catenin signaling pathway through ubiquitination of AXIN1, thereby regulating apoptosis. Collectively, this study reveals that TRIM32 promotes inflammatory factor-induced apoptosis of rat NP cells, in part by direct degradation of AXIN1 to trigger ß-catenin signaling.

C2 Pedicle Screws Combined With C1 Laminar Hooks for Reducible Atlantoaxial Dislocation: An Ideal Salvage Technique for C1-C2 Pedicle Screws.

BACKGROUND: A C1 laminar hook can theoretically avoid vertebral artery injury and is less technically demanding. However, only few studies with small samples analyzed the short-term outcomes of C2 pedicle screws combined with C1 laminar hooks (C2PS-C1LH) technique in the treatment of atlantoaxial dislocation. Furthermore, it is not confirmed whether similar clinical outcomes can be achieved with C1-C2 pedicle screw and rod construct (PSRC). OBJECTIVE: To evaluate the outcomes of C2PS-C1LH and C1-C2 PSRC fixation techniques for treating atlantoaxial dislocation. METHODS: Data of 52 patients with atlantoaxial dislocation treated by C1-C2 PSRC or C2PS-C1LH fixation were retrospectively reviewed. Outcomes evaluated by visual analog scale score for neck pain (VASSNP), Neck Disability Index (NDI), atlantodental interval (ADI), and the perioperative parameters including blood loss and operation time were analyzed and compared between 2 techniques. Patient satisfaction at final follow-up was also investigated. RESULTS: There were no complications related to the surgical approach and instrumentation in either group. The mean bone fusion time was 5.06 ± 1.65 mo for the C2PS-C1LH group and 3.93 ± 0.99 mo for the C1-C2 PSRC group (P > .05). Hundred percent of fusion rates were achieved in both groups at month 12 after operation. The ADI, VAS scores, the NDI scores, and the JOA scores were greatly improved in both the groups (P < .05), but there were no significant differences between the 2 groups. CONCLUSION: C2PS-C1LH fixation technique was comparable to C1-C2 PSRC in the treatment of reducible atlantoaxial dislocation. C2PS-C1LH fixation was an ideal alternative strategy to C1-C2 PSRC fixation.

Is Initial Posterior Atlantoaxial Fixation and Fusion Applying Bilateral C1-2 Transarticular Screws and C1 Laminar Hooks Reliable for Acute Pediatric Atlantoaxial Instability?: A Minimal 10-Year Analysis of Outcome and Radiological Evaluation.

STUDY DESIGN: A retrospective case series study with at least 10 years of follow-up data. OBJECTIVE: To validate the reliability of bilateral C1-2 transarticular screws and C1 laminar hooks and a bone autograft for acute pediatric atlantoaxial instability. SUMMARY OF BACKGROUND DATA: The reliability of initial posterior atlantoaxial fusion in pediatric patients is still controversial. To date, however, only a few published articles with short-term follow-up data are available to help spinal surgeons understand the effects of posterior atlantoaxial fusion in the skeletally immature spine. METHODS: Five pediatric patients with acute atlantoaxial instability underwent atlantoaxial fusion using the above technique over a 3-year period. During a minimum 10-year follow-up period, not only outcomes and complications were investigated, but the vertical growth of the constructed spine in relation to the growth of the entire cervical spine, overall cervical spinal alignment, and adjacent-segment instability were evaluated. RESULTS: The clinical follow-up indicated solid fusion and complete clinical relief from symptoms. No neural or vascular impairment was observed. The radiological evaluation showed that all patients had growth within the fusion construct reaching a mean 35.4% of the entire cervical spine. There were no radiological indicators of subaxial instability, even when cervical sagittal alignments became straight with a mean C2-7 angle of 6.4°. CONCLUSION: The results showed that initial posterior atlantoaxial fusion accomplished with bilateral C1-2 transarticular screws, C1 laminar hooks fixation, and bony autograft is a reliable surgical technique for treating acute pediatric atlantoaxial instability without negative effects on vertical growth at the fused level or the stability of the subaxial spine. LEVEL OF EVIDENCE: 3.

Biomechanics of the effect of subaxial cervical spine degeneration on atlantoaxial complex in idiopathic retro-odontoid pseudotumor development.

OBJECTIVES: Retro-odontoid pseudotumor (ROP), with no rheumatoid arthritis, atlantoaxial instability, or other primary diseases, is defined as idiopathic retro-odontoid pseudotumor (IROP). Cervical spine degeneration is associated with IROP development. This study aims to evaluate the effect of cervical spine degeneration on the atlantoaxial complex and find the possible biomechanical mechanism of IROP development. METHODS: This study was performed using a three-dimensional (3D) finite element (FE) analysis. A degenerated FE model (FEM) and five operation FEMs (C1-C2 fusion, C0-C2 fusion, C0-C3 fusion, C0-C4 fusion, and C1 posterior arch resection) were established based on a normal 3D FEM of the cervical spine including C0-T1 with the main ligaments and muscles. The parameters, including the C1-C2 range of motions (ROMs) and odontoid-related ligaments' stresses in degenerated and operation FEMs, were obtained and compared with those in normal FEM. RESULTS: Compared to normal FEM, degenerated FEM had reduced C3-C7 ROMs and increased C1-C2 ROMs and odontoid-related ligaments' stresses. After internal fixation, C1-C2 ROMs and most odontoid-related ligaments' stresses were greatly decreased, but with no significant differences among C0-C2, C0-C3, C0-C4, and C1-C2 fusion models. For the C1 posterior arch resection model, C1-C2 ROMs and most odontoid-related ligaments' stresses increased, compared with normal FEM. CONCLUSIONS: Cervical spine degeneration plays an important part in IROP development in biomechanics. Atlantoaxial complex compensates for cervical spine degeneration, with increased C1-C2 ROMs and odontoid-related ligaments' stresses. Atlantoaxial fusion or short segmental occipitocervical fusion can effectively reduce the stress and should be considered in IROP treatment.

Cervicomedullary angle as an independent radiological predictor of postoperative neurological outcome in type A basilar invagination.

To propose an independent radiological index to evaluate surgical outcomes of A type basilar invagination, a retrospective study was conducted to compare the clinical outcome between procedures 1 and 2 by applying intraoperative consistent traction and manual reduction. Moreover, the atlantodental interval (ADI), cervicomedullary angle (CMA), bilateral sagittal inclination of atlantoaxial joint (SIAA) were measured and compared to pre-operation. Postoperatively, only these patients undergoing procedure 2 achieved significant neurological improvement. The ADIs and the SIAAs decreased in both groups, these differences are statistically significant between pre- and post- operation. For postoperative CMAs, only these patients undergoing modified surgery gained significant improvement of angle with mean 141°. We concluded that the CMA or SIAA could be a radiological predictor to evaluate surgical outcome in BI, among which the CMA is a more independent and easily measurable predictor that is closely correlated with satisfactory neurological improvements. Moreover, procedure 2 with intraoperative resistant cranial traction and manual reduction can help us achieve a good CMA.

Comparison of Outcomes Between Anterior Cervical Decompression and Fusion and Posterior Laminoplasty in the Treatment of 4-Level Cervical Spondylotic Myelopathy.

OBJECTIVE: To compare the outcome of anterior cervical decompression and fusion (ACDF) and posterior laminoplasty (LAMP) for treating 4-level cervical spondylotic myelopathy (CSM). METHODS: Data of 80 patients with 4-level CSM treated using ACDF and another 56 cases treated using LAMP were retrospectively analyzed. Radiologic outcomes evaluated by C2-7 Cobb angle and cervical range of motion (ROM) and functional outcomes evaluated by Japanese Orthopaedic Association (JOA) scale score and visual analog scale score for axial pain were compared between the 2 groups. RESULTS: JOA scale score in both groups improved significantly after operation (P < 0.05). There was no significant difference in the JOA scale score improvement rate between the 2 groups (P > 0.05). The C2-7 Cobb angle increased significantly in the ACDF group (P < 0.05) and decreased in the LAMP group (P > 0.05). There was a significant difference in C2-7 Cobb angle improvement between the 2 groups (P < 0.05). Cervical ROM decreased in both groups after operation (P < 0.05), but there was no significant difference in ROM loss ratio between the 2 groups (P > 0.05). Blood loss in the LAMP group was significantly more than in the ACDF group (P < 0.05); however, there was no significant difference in operation time between the 2 groups (P > 0.05). There was no significant difference in the complication rate between the 2 groups (P > 0.05). CONCLUSIONS: Both ACDF and LAMP were effective in the treatment of multilevel CSM. Compared with LAMP, ACDF is less invasive and may be more suitable for elderly patients with poor tolerance of surgery.