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Int J Artif Organs ; 9(5): 327-30, 1986 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-3781664

RESUMO

A jaundiced dog model was made by common bile duct-inferior vena cava shunt with a silicon rubber tube. Blood bilirubin levels increased from 0.25 +/- 0.16 (SD) mg% to 15 +/- 1.4 (SD) mg%. These dog models were treated with a column containing 200 gm of macroreticular resin NK-110 which was linked between the femoral artery and vein. The rate of blood flow through the column was 200 ml/min. It was shown that total bilirubin reduced from 15 +/- 1.4 (SD) to 7.4 +/- 0.61 (SD), conjugated bilirubin decreased from 6.97 +/- 0.63 to 3.5 +/- 0.33 (SD) and unconjugated bilirubin from 7.8 +/- 2.1 to 4.2 +/- 0.4 (SD). There were no significant changes in protein, electrolyte, blood gases and acid base balance. Results show that NK-110 resin has good blood-compatible and adsorption properties.


Assuntos
Bilirrubina/metabolismo , Hemoperfusão , Icterícia/terapia , Poliestirenos , Resinas Sintéticas , Adsorção , Animais , Modelos Animais de Doenças , Cães , Feminino , Resinas de Troca Iônica , Masculino
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