Efficacy of Transcranial Direct Current Stimulation Combined with Conventional Swallowing Rehabilitation Training on Post-stroke Dysphagia.

To observe the clinical effects of transcranial direct current stimulation (tDCS) combined with conventional swallowing rehabilitation training on post-stroke dysphagia and explore its long-term efficacy. A total of 40 patients with dysphagia after the first stroke were randomly divided into a treatment group (n = 20) and a conventional group (n = 20). The treatment group received tDCS combined with conventional swallowing rehabilitation training, while the conventional group only received conventional swallowing rehabilitation training. The Standardized Swallowing Assessment (SSA) Scale and the Penetration-Aspiration Scale (PAS) were used to assess dysphagia before and after treatment, at the end of 10 treatments, and at the 3-month follow-up. The changes in infection indicators [the white blood cell (WBC), C-reactive protein (CRP) and procalcitonin (PCT)], the oxygenation indicator [arterial partial pressure of oxygen (PaO2)] and nutrition-related indicators [hemoglobin (Hb) and serum prealbumin (PAB)] were compared before and after treatment. The SSA and PAS scores were lower in both groups after treatment than before treatment, and the difference was statistically significant (P < 0.01). The SSA and PAS scores of the treatment group were lower than those of the conventional group before and after treatment and during follow-up, and the difference was statistically significant (P < 0.05, P < 0.01). A within-group comparison showed that WBC, CRP and PCT after treatment were lower than those before treatment, and the difference was statistically significant (P < 0.05). The PaO2, Hb and serum PAB were higher after treatment than before treatment, with a statistically significant difference (P < 0.05). The WBC, CRP and PCT of the tDCS group were lower than those of the conventional group, and PaO2, Hb and serum PAB were higher in the treatment group than in the conventional group, with a statistically significant difference (P < 0.01). The tDCS combined with conventional swallowing rehabilitation training can improve dysphagia with a better effect than conventional swallowing rehabilitation training and has a certain long-term efficacy. In addition, tDCS combined with conventional swallowing rehabilitation training can improve nutrition and oxygenation and reduce infection levels.

Ultracompact Orbital Angular Momentum Sorter on a CMOS Chip.

On-chip integrated orbital angular momentum (OAM) sorting is of great importance in tackling the severe challenge of exponential growth in data traffic. Despite the continuous success, current demultiplexing techniques either scarify efficiency dramatically or lose the compactness of a system. Here we experimentally demonstrate an ultracompact OAM sorter using TiO2 metasurfaces integrated onto a complementary metal-oxide-semiconductor (CMOS) camera. By utilizing the propagation phases, we transfer the unitary transformation theory in bulky systems into two TiO2 metasurfaces, responsible for the functions of log-polar transformation and fan-out beam copying and focusing as well as the functions of phase correction and Fourier transform. The flatform metasurface doublet enables one to integrate the OAM sorter onto a camera chip. Consequently, OAM beams with topological charges of m = -3 to 3 were separated by a CMOS camera with an average crosstalk of -6.43 dB. This approach shall shed light on next-generation OAM modes processing.

All-Dielectric Metasurface-Enabled Multiple Vortex Emissions.

On-chip integrated micro- and nanoscale vortex lasers are key elements for addressing the exponentially growing demand for information capacity. Although tunable vortex microlasers have been reported, each laser pulse still possesses one particular topological charge and requires additional multiplexing. In this study, the simultaneous generation of coherent laser arrays with different topological charges by combining metalenses with semiconductor microlasers is demonstrated. A TiO2 vortex metalens converts two orbital angular momentum beams into the same diffraction-limit spot with opposite circular polarizations through spin-to-orbital conversion. Consequently, the microlaser emission at the focal spot, which can be decomposed into two circularly polarized beams, is collimated into vortex microlaser beams with two different topological charges through a time-reversal process. This concept is extended to a 2 × 2 metalens array by introducing off-axis terms, and eight topological charges are produced simultaneously. This research is a significant step toward the on-chip integration of micro- and nanolasers.

Music induced happy mood suppresses the neural responses to other's pain: Evidences from an ERP study.

In the current study, we explored the time course of processing other's pain under induced happy or sad moods. Event-related potentials (ERPs) were recorded when participants observing pictures showing others in painful or non-painful situations. Mood induction procedures were applied to the participants before the picture observation task. Happy and sad moods were induced by listening to about 10 minutes of music excerpts selected from the Chinese Affective Music System (CAMS). The ERP results revealed that the induced mood can influence the early automatic components N1, P2, and N2 but not the later top-down controlled components P3 and LPP. The difference of amplitudes elicited by painful and non-painful stimuli was significantly different only in a sad mood but not in a happy mood, which indicates that comparing to a sad mood, the participants' ability to discriminate the painful stimuli from the non-painful stimuli was weakened in a happy mood. However, this reduction of sensitivity to other's pain in a happy mood does not necessarily reduce the tendency of prosocial behaviors. These findings offer psychophysiological evidences that people's moods can influence their empathic response towards other's pain.

Working memory load modulates the neural response to other's pain: Evidence from an ERP study.

The present study investigated the time course of processing other's pain under different conditions of working memory (WM) load. Event-related potentials (ERPs) were recorded while the participants held two digits (low WM load) or six digits (high WM load) in WM and viewed pictures that showed others who were in painful or non-painful situations. Robust WM-load×Picture interactions were found for the N2 and LPP components. In the high WM-load condition, painful pictures elicited significantly larger amplitudes than non-painful pictures. In the low WM load condition, the difference between the painful and non-painful pictures was not significant. These ERP results indicate that WM load can influence both the early automatic N2 component and late cognitive LPP component. Compared with high WM load, low WM load reduced affective arousal and emotional sharing in response to other's pain and weakened the cognitive evaluation of task irrelevant stimuli. These findings are explained from the load theory perspective.