Facial Emotion Perceptual Tendency in Violent and Non-violent Offenders.

All three authors share equal authorship in this paper.Emotion perception has a vital influence on social interaction. Previous studies discussed mainly the relationship between facial emotion perception and aggressive behavior from the perspective of hostile attributional bias and the impaired violence inhibition mechanism. The present study aims to provide new evidence of different emotion perception patterns between the violent and non-violent criminal samples through a new indicator of the facial emotion recognition test, Facial Emotion Perception Tendency (FEPT), calculated by counting the times a participant recognizes a set of emotional stimuli as a particular specific emotion, and to further examine the association between aggressive behaviors and FEPT. 101 violent and 171 non-violent offenders, as well as 81 non-offending control participants, were recruited to complete the emotion recognition task with morphed stimuli (Study 1). We further recruited 62 non-offending healthy male participants to finish the Buss -Perry Aggression Questionnaire (BPAQ) after the emotion recognition task in Study 2. Both non-violent and violent offenders were significantly lower in overall accuracy of emotion recognition and disgust FEPT, but higher in happy FEPT, than non-offending healthy controls. Non-violent offenders had significantly lower fear FEPT than violent offenders, and had higher anger FEPT than non-offending controls. The results also revealed that the level of physical aggression was positively correlated with fear FEPT, while negatively correlated with anger FEPT. The current study demonstrated that FEPT was associated with aggressive behavior and implies the importance of improving the emotion decoding ability of offenders. Also, the concept "FEPT" proposed in this study is of significance for further exploration of how individuals' tendency to perceiving a particular emotion can be correlated with social behaviors.

A pair of long intergenic non-coding RNA LINC00887 variants act antagonistically to control Carbonic Anhydrase IX transcription upon hypoxia in tongue squamous carcinoma progression.

BACKGROUND: Long noncoding RNAs (lncRNAs) are important regulators in tumor progression. However, their biological functions and underlying mechanisms in hypoxia adaptation remain largely unclear. RESULTS: Here, we established a correlation between a Chr3q29-derived lncRNA gene and tongue squamous carcinoma (TSCC) by genome-wide analyses. Using RACE, we determined that two novel variants of this lncRNA gene are generated in TSCC, namely LINC00887_TSCC_short (887S) and LINC00887_TSCC_long (887L). RNA-sequencing in 887S or 887L loss-of-function cells identified their common downstream target as Carbonic Anhydrase IX (CA9), a gene known to be upregulated by hypoxia during tumor progression. Mechanistically, our results showed that the hypoxia-augmented 887S and constitutively expressed 887L functioned in opposite directions on tumor progression through the common target CA9. Upon normoxia, 887S and 887L interacted. Upon hypoxia, the two variants were separated. Each RNA recognized and bound to their responsive DNA cis-acting elements on CA9 promoter: 887L activated CA9's transcription through recruiting HIF1α, while 887S suppressed CA9 through DNMT1-mediated DNA methylation. CONCLUSIONS: We provided hypoxia-permitted functions of two antagonistic lncRNA variants to fine control the hypoxia adaptation through CA9.

Decoding the role of long noncoding RNAs in the healthy aging of centenarians.

Aging is the largest risk factor of major human diseases. Long noncoding RNAs (lncRNAs) as the key regulatory elements have shown a strong impact on multiple biological processes as well as human disease mechanisms. However, the roles of lncRNAs in aging/healthy aging processes remain largely unknown. Centenarians are good models for healthy aging studies due to avoiding major chronic diseases and disabilities. To illustrate their ubiquitous nature in the genome and the 'secrets' of healthy aging regulation from the perspective of lncRNAs, peripheral blood samples from two regions consisting 76 centenarians (CENs), 54 centenarian-children (F1) and 41 spouses of centenarian-children (F1SP) were collected for deep RNA-seq. We identified 11 CEN-specific lncRNAs that is particularly expressed in longevous individuals. By kmers clustering, hundreds of human lncRNAs show similarities with CEN-specific lncRNAs, especially with ENST00000521663 and ENST00000444998. Using F1SP as normal elder controls (age: 59.9 ± 6.6 years), eight lncRNAs that are differentially expressed in longevous elders (CEN group, age: 102.2 ± 2.4 years) were identified as candidate aging/health aging-related lncRNAs (car-lncs). We found that the expression of eight car-lncs in human diploid fibroblasts displayed dynamic changes during cell passage and/or H2O2/rapamycin treatment; of which, overexpression either of THBS1-IT1 and THBS1-AS1, two lncRNAs that highly expressed in CENs, can remarkably decrease p16, p21 and the activity of senescent related ß-galactosidase, suggesting that THBS1-IT1 and THBS1-AS1 can inhibit cellular senescence. We provided the first comprehensive analysis of lncRNA expression in longevous populations, and our results hinted that dysregulated lncRNAs in CENs are potential protective factors in healthy aging process.

Insights into long noncoding RNAs of naked mole rat (Heterocephalus glaber) and their potential association with cancer resistance.

BACKGROUND: Long noncoding RNAs (lncRNAs) are a class of ubiquitous noncoding RNAs and have been found to act as tumor suppressors or oncogenes, which dramatically altered our understanding of cancer. Naked mole rat (NMR, Heterocephalus glaber) is an exceptionally long-lived and cancer-resistant rodent; however, whether lncRNAs play roles in cancer resistance in this seductive species remains unknown. RESULTS: In this study, we developed a pipeline and identified a total of 4422 lncRNAs across the NMR genome based on 12 published transcriptomes. Systematic analysis revealed that NMR lncRNAs share many common characteristics with other vertebrate species, such as tissue specificity and low expression. BLASTN against with 1057 human cancer-related lncRNAs showed that only 5 NMR lncRNAs displayed homology, demonstrating the low sequence conservation between NMR lncRNAs and human cancer-related lncRNAs. Further correlation analysis of lncRNAs and protein-coding genes indicated that a total of 1295 lncRNAs were intensively coexpressed (r ≥ 0.9 or r ≤ -0.9, cP value ≤ 0.01) with potential tumor-suppressor genes in NMR, and 194 lncRNAs exhibited strong correlation (r ≥ 0.8 or r ≤ -0.8, cP value ≤ 0.01) with four high-molecular-mass hyaluronan related genes that were previously identified to play key roles in cancer resistance of NMR. CONCLUSION: In this study, we provide the first comprehensive genome-wide analysis of NMR lncRNAs and their possible associations with cancer resistance. Our results suggest that lncRNAs may have important effects on anticancer mechanism in NMR.

Perceiving and interacting affordances: a new model of human-affordance interactions.

This article introduces a new affordance framework for humans and human design. Based on previous important concepts in product design-affordance, signifier, and product semantics, the authors propose three new concepts to illustrate how people perceive affordance. According to the model, perceptual probability of affordance is the probability that the public can perceive a certain affordance; perceptual threshold of affordance is the threshold at which affordance can be perceived by a person and changed by perceptual information; and situations, in which interactions between affordances and people exist, are crucial influences on human-affordance interactions. An illustration of the model and suggestions for further research are provided.

4,6-Bis[4-(benzyl-sulfan-yl)styr-yl]-2-(methyl-sulfan-yl)pyrimidine.

The title compound, C(35)H(30)N(2)S(3), has been synthesized by a solvent-free reaction. The mol-ecule exhibits an E,E configuration, the benzene rings and pyrimidine rings being located on the opposite sides of the C=C bonds. The centroid-centroid separation of 3.5808 (17) Šindicates the existence of π-π stacking between nearly parallel pyrimidine and benzene rings of adjacent mol-ecules.