Hydroxy-safflower yellow A composites: An effective strategy to enhance anti-myocardial ischemia by improving intestinal permeability.

Hydroxy-safflower yellow A (HSYA) is the chief component of safflower against myocardial ischemia (MI), and belongs to biopharmaceutics classification system (BCS) III drugs. Its structure contains multiple hydroxyl groups, contributing to its high polarity and poor oral bioavailability. The main objective of this study was to probe the potential of oral penetration enhancer n-[8-(2-hydroxybenzoyl) amino] sodium octanoate (SNAC) and cationic copolymer Eudragit®EPO (EPO) to promote absorption of HSYA. HSYA composites (SNAC-HSYA-EPO) were formed by hydrogen bonding and van der Waals force. SNAC-HSYA-EPO has biocompatibility, and can improve the membrane fluidity, uptake, transport, and penetration of Caco-2 cells. The mechanism of promoting of SNAC-HSYA-EPO may be related to energy and P-glycoprotein (P-gp) when compared with the inhibitor NaN3 and verapamil group. In the pharmacokinetic (PK) results, SNAC-HSYA-EPO significantly improved oral bioavailability. Pharmacodynamics (PD) results determined that SNAC-HSYA-EPO could improve the symptoms of MI. The mechanism of the SNAC-HSYA-EPO anti-MI is related to alleviating inflammation and anti-apoptosis to protect the heart. In summary, SNAC-HSYA-EPO prepared in this study possessed a complete appearance, high recombination rate and excellent oral permeability promoting ability. SNAC-HSYA-EPO has the potential to improve oral bioavailability and further enhance the anti-MI effect of HSYA.

pH-responsive hierarchical H2S-releasing nano-disinfectant with deep-penetrating and anti-inflammatory properties for synergistically enhanced eradication of bacterial biofilms and wound infection.

BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) biofilm-associated bacterial infection is the primary cause of nosocomial infection and has long been an ongoing threat to public health. MRSA biofilms are often resistant to multiple antimicrobial strategies, mainly due to the existence of a compact protective barrier; thus, protecting themselves from the innate immune system and antibiotic treatment via limited drug penetration. RESULTS: A hierarchically structured hydrogen sulfide (H2S)-releasing nano-disinfectant was presented, which was composed of a zinc sulfide (ZnS) core as a H2S generator and indocyanine green (ICG) as a photosensitizer. This nano-disinfectant (ICG-ZnS NPs) sensitively responded to the biofilm microenvironment and demonstrated efficient eradication of MRSA biofilms via a synergistic effect of Zn2+, gas molecule-mediated therapy, and hyperthermia. Physically boosted by released H2S and a near-infrared spectroscopy-induced hyperthermia effect, ICG-ZnS NPs destroyed the compactness of MRSA biofilms showing remarkable deep-penetration capability. Moreover, on-site generation of H2S gas adequately ameliorated excessive inflammation, suppressed secretion of inflammatory cytokines, and expedited angiogenesis, therefore markedly accelerating the in vivo healing process of cutaneous wounds infected with MRSA biofilms. CONCLUSION: ICG-ZnS NPs combined with NIR laser irradiation exhibited significant anti-biofilm activity in MRSA biofilms, can accelerate the healing process through deep-penetration and anti-inflammatory effectuation. The proposed strategy has great potential as an alternative to antibiotic treatment when combating multidrug-resistant bacterial biofilms.

Nanocarrier-based delivery of arsenic trioxide for hepatocellular carcinoma therapy.

Hepatocellular carcinoma (HCC) poses a severe threat to human health and economic development. Despite many attempts at HCC treatment, most are inevitably affected by the genetic instability and variability of tumor cells. Arsenic trioxide (ATO) has shown to be effective in HCC. However, time-consuming challenges, especially the optimal concentration in tumor tissue and bioavailability of ATO, remain to be overcome for its transition from the bench to the bedside. To bypass these issues, nanotechnology-based delivery systems have been developed for prevention, diagnosis, monitoring and treatment in recent years. This article is a systematic overview of the latest contributions and detailed insights into ATO-loaded nanocarriers, with particular attention paid to strategies for improving the efficacy of nanocarriers of ATO.

Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death worldwide; it is highly aggressive, has a poor prognosis and is often diagnosed late in the disease course. Arsenic trioxide (ATO), an established agent for the treatment of acute promyelocytic leukemia, has shown powerful therapeutic potential in the treatment of HCC. However, its narrow therapeutic window and severe toxicity, as well as resistance to ATO, limit its application for HCC treatment. Nanocarriers have been employed to deliver ATO to achieve effective therapeutic outcomes in HCC. This review describes the application of various nanocarrier-based delivery systems for ATO to enhance the effectiveness of tumor therapy and reduce its side effects, thus making it a promising therapeutic strategy for in HCC.

A biomimetic SiO2@chitosan composite as highly-efficient adsorbent for removing heavy metal ions in drinking water.

Highly efficient adsorbents for drinking water purification are demanded since the contaminants are generally in a low concentration which makes it difficult for conventional adsorbents. Herein, we present a novel biomimetic SiO2@chitosan composite as adsorbent with a high adsorption capability towards heavy metal ions including As(V) and Hg(II). The hollow leaf-like SiO2 scaffold within the adsorbent has a stable chemical property; while on the surface SiO2, the chitosan nanoparticle provide a large amount of active sites such as amino and hydroxyl groups for adsorbing heavy metal ions. The special SiO2 structure also prevents the agglomeration and loss of chitosan, which enables the efficient contact between the functional groups of chitosan and heavy metal ions. The SiO2@chitosan composite exhibits maximum adsorption capacities of 204.1 and 198.6 mg g-1 towards Hg(II) and As(V), respectively. In addition, the removal efficiency reaches over 60% within 2 min. The adsorption performance enables the presented biomimetic adsorbent suitable for adsorbing low-concentration heavy metal ions, especially possessing a promising potential for drinking water purification.

Evaluating the Efficiency of Municipal Solid Waste Management in China.

Poor public health is always associated with the mismanagement of municipal solid waste (MSW). Many cities are besieged by MSW in the world. It is essential to do a good job in MSW management (MSWM). In order to improve the efficiency of MSWM, the Chinese government has intensively implemented relevant policies. There are still few studies on MSWM efficiency in China. The research aims to comprehensively analyze MSWM efficiency, find high-efficiency MSWM policy implementation routes and the breakthrough on improving MSWM efficiency. To measure Chinese MSWM efficiency accurately, this paper introduced the three-stage data envelopment analysis (DEA) model into the research. According to the results of DEA, Fuzzy c-Means algorithm was used to the cluster analysis of 33 typical cities. After eliminating the interference of the external environment and random disturbance, the mean value of MSWM efficiency declined from 0.575 to 0.544. The mean of pure technical efficiency (PTE) was declined from 0.966 to 0.611, while the mean of scale efficiency (SE) increased from 0.600 to 0.907. The PTE of central and northeastern cities was relatively low. The SE of western cities was comparatively high and the efficiency distribution of the eastern region was relatively scattered. In general, MSWM efficiency is low and expected to be improved. Regional differences in MSWM efficiency have been shown. The management effectiveness of eight pilot cities (MSW classification) is affirmative but not that significant. To improve MSWM efficiency, differential management for four types of cities should be carried out.