[Antimicrobial activity of ceftazidime and its pharmacokinetics in patients with renal failure]. / Antimikrobnaia aktivnost' tseftazidima i ego farmakokinetika u bol'nykh s pochechnoi nedostatochnost'iu.

High antimicrobial activity of ceftazidime against clinical gram-positive (except Streptococcus viridans and S. faecalis) and gram-negative strains of microorganisms was shown. It was found that the drug dosing regimens required correction in cases with impaired excretion function of the kidneys. Hemodialysis lowered 2-4 times the drug blood levels.

[Ultraviolet irradiation of the blood in the treatment of pyo-inflammatory complications in patients with terminal renal failure]. / Ul'trafioletovoe obluchenie krovi v lechenii gnoino-vospalitel'nykh oslozhnenii u bol'nykh terminal'noi pochechnoi nedostatochnost'iu.

The authors describe a technique of extracorporeal UV radiation of blood (EUVRB) in flow closed circulation. Its efficacy was assessed in combined treatment of pyo-inflammatory complications of terminal renal failure. Therapeutic effects of EUVRB are due to reduced endogenic intoxication, correction of leukopoiesis and stimulation of immunity. The changes in laboratory findings correlated with clinical pattern of the inflammation. EUVRB produced a favourable response and improved therapeutic results of pyo-inflammation treatment in patients with terminal renal failure.

[Immunologic criteria of severity of suppurative infections in patients on programmed hemodialysis]. / Immunologicheskie kriterii tiazhesti gnoinoi infektsii u bol'nykh programmnom gemodialize.

Certain parameters of the immune system were studied in patients under programmed hemodialysis with and without pyo-inflammatory complications. It was found that patients without pyo-inflammatory diseases are characterized by the state of immune deficiency while in patients with purulent infection the degree of inhibition of immune response of the organism correlates with spread of the suppurative process.

[Ultrastructural changes in the erythrocytes irradiated with ultraviolet light]. / Ul'trastrukturnye izmeneniia éritrotsitov, obluchennykh ul'trafioletovym svetom.

The ultrastructure of erythrocytes of donor blood and blood of patients suffering from kidney insufficiency was studied with the help of scanning and transmission electron microscopes before and after it was treated with ultraviolet light. It was concluded that after being treated with ultraviolet light, the ultrastructure of donor blood erythrocytes undergoes significant positive changes which are being characterized by normalization of the form of cells, decrease of associative ties between them, the cytoplasm content becomes more homogenous. There was a noticeable increase of a number of discocytes and a decreased number of associative ties between the cells after the patients' own blood was treated with ultraviolet light. The violation of the wholesomeness of erythrocytes membrane was not discovered. The indications are that the observed therapeutical effect after treating blood with ultraviolet light, is explained, to a certain extent, by the ultrastructural modification of erythrocytes membrane.

[Morphofunctional changes in blood cells irradiated with ultraviolet light]. / Morfofunktsional'nye izmeneniia kletok krovi, obluchennoi ul'trafioletovym svetom.

Red cell and leukocyte morphology and function have been examined in donor blood UV irradiated in a flow closed circulation. The studies have revealed that a single UV irradiation enhances red cell resistance to chemical hemolysis, helps them acquire normal shape; besides, it improves leukocytic functional activity, that manifests by enhanced phosphatase activity and augmentation of the granulocyte phagocytic activity.

[The effect of ultraviolet irradiation of patients' blood on the morphofunctional status of erythrocytes]. / Vliianie ul'trafioletovogo oblucheniia krovi bol'nykh na morfofunktsional'noe sostoianie éritrotsitov.

The morphofunctional status of red blood cells was studied in patients with terminal renal failure associated with pyo-inflammatory complications treated by means of ultraviolet radiation of autologous blood. The authors have established that ultraviolet radiation of autologous blood results in the increase of the discocyte count and red blood cell activation, evidenced by the rise of the young red blood cell count, of the red blood cell population with marked activity of glucose 6-phosphate dehydrogenase, of the content of sulfhydryl groups, and by the increase of erythrocytic adhesion.

[Combined methods of extracorporeal detoxication in the treatment of severe surgical endotoxemia]. / Kombinirovannye metody ékstrakorporal'noi detoksikatsii v lechenii tiazhelykh khirurgicheskikh éndotoksikozov.

A combined method of treatment--flowing ultraviolet irradiation of autoblood with hemosorption or exchange plasmapheresis--was used in 52 patients with pyoseptic diseases. It was shown that inclusion of combined extracorporal detoxication in the complex treatment was followed by a pronounced clinical effect and correction of biochemical and physiological parameters.

[Pharmacokinetics of cefazolin during hemosorption and hemodialysis]. / Farmakokinetika tsefazolina pri gemosorbtsii i gemodializa.

The influence of hemosorption and hemodialysis on the pharmacokinetics of cefazolin was studied in 20 patients with chronic and acute renal insufficiency. The integral mean value of the antibiotic extraction coefficient in hemosorption was approximately 2 times higher than that in hemodialysis. In the first case the value of this parameter systematically lowered with time (the constant of the process rate amounted to 0.89 h-1), while in the second case it was constant.