RESUMO
Studies in kinetics of production of slightly soluble aggregates of immunoglobulin G characteristic of malignant growth with serum alpha-globulins under the effect of the acid medium on the sera of cancer patients resulted in establishing that this process is subjected to the equation first order reaction. The analysis of the kinetic curves showed that immunoglobulin G characteristic of malignant growth is available in blood of the patients at all the stages of the tumour development.
Assuntos
Imunoglobulina G , Neoplasias/imunologia , Humanos , Cinética , Substâncias Macromoleculares , Matemática , Neoplasias/fisiopatologia , SolubilidadeRESUMO
Application of the refractometric method for estimating intramolecular sorption of hydrocarbon by proteins permitted detecting some differences in the hydrophobic structure of immunoglobulin G peculiar to the malignant growth and of immunoglobin G of the healthy organism. An increase in the specific hydrophobic capacity of immunoglobulin G peculiar to the malignant growth due to large hydrophobic regions makes it possible to conclude that this protein globular packing is less compact and looser.