Preventing the recurrence of depression with a Mediterranean diet supplemented with extra-virgin olive oil. The PREDI-DEP trial: study protocol.

BACKGROUND: The role of dietary patterns in the prevention of unipolar depression has been analyzed in several epidemiological studies. The primary aims of this study are to determine the effectiveness of an extra-olive oil-enriched Mediterranean diet in reducing the recurrence of depression and improving the symptoms of this condition. METHODS: Multicenter, two-arm, parallel-group clinical trial. Arm 1, extra-virgin olive oil Mediterranean diet; Arm 2, control group without nutritional intervention. Dieticians are in charge of the nutritional intervention and regular contact with the participants. Contacts are made through our web platform ( https://predidep.es/participantes/ ) or by phone. Recurrence of depression is assessed by psychiatrists and clinical psychologists through clinical evaluations (semi-structured clinical interviews: Spanish SCID-I). Depressive symptoms are assessed with the Beck Depression Inventory. Information on quality of life, level of physical activity, dietary habits, and blood, urine and stool samples are collected after the subject has agreed to participate in the study and once a year. DISCUSSION: To the best of our knowledge, the PREDI-DEP trial is the first ongoing randomized clinical trial designed to assess the role of the Mediterranean diet in the prevention of recurrent depression. It could be a cost-effective approach to avoid recurrence and improve the quality of life of these patients. TRIAL REGISTRATION: The study has been prospectively registered in the U.S. National Library of Medicine ( https://clinicaltrials.gov ) with NCT number: NCT03081065.

Revisión histórica del concepto de trastorno de la personalidad / Historical evolution of the concept of personality disorder

El objetivo de este trabajo es revisar la evolución histórica del concepto de trastorno de la personalidad. Desde las primeras aportaciones de la cultura griega hasta las actuales clasificaciones internacionales se estudiará cómo el concepto de trastorno de la personalidad ha variado con el transcurso de los años, enriqueciéndose y desarrollándose con las aportaciones de diferentes escuelas, investigaciones y teorías de autor. Se incide en el desarrollo del concepto durante los siglos XIX y XX –con la aparición dela psicología científica- hasta llegar al actual concepto

The aim of this study is to review the historical evolution of the concept of personality disorder. It will be studied how the concept of personality disorder has changed over the course of years –from the very first contributions of the Greek culture up to the current international classifications-, how it has prospered and developed with the contributions of the different schools, researches and personal author´s theories. Special attention will be paid to the development of the concept from the XIXth and XXth centuries –with the beginning of the scientific psychology – into the current concept