[Morphological and cytochemical characteristics of spontaneous hemoblastoses in AKR mice]. / Morfologicheskaia i tsitokhimicheskaia kharakteristika spontannykh gemoblastozov myshei linii AKR.

Spontaneous hemoblastoses of AKR mice are widely used in experimental oncology and hematology. To study their morphological characteristics, 500 AKR mice were used. Of these, 400 animals were followed up throughout their lives. Ten animals were sacrificed monthly out of the group of 100 rats. All the animals which died or were sacrificed were autopsied and subjected to cytological and histological studies. Besides, 36 animals with hemoblastoses were examined cytochemically for the activity of acid and alkaline phosphatases, peroxidase and nonspecific esterase and glycogen. Analysis of the data obtained suggests that hemoblastoses of AKR mice are the generalized forms of lymphosarcoma, characterized by a significant degree of cytochemical and cytological heterogeneity.

[Transplacental blastomogenic effect of p-hydroxyphenyl lactic acid]. / Transplatsentarnoe blastomogennoe deistvie p-oksifenilmolochnoi kisloty.

Transplacental administration of tyrosine metabolite p-hydroxyphenyl lactic acid having blastomogenic activity induced development of malignant and benign neoplasms (leukemias and lymphosarcomas, adenomas and pulmonary carcinoma, hepatomas, papillomas, and cancer of the urinary bladder and other tumours) in progeny of CC57BR and C57BL mouse strains, in 88 and 78% of cases, respectively. The number of neoplasms was significantly higher, than in the control, they appeared earlier and were of more malignant character. The role of endogenous blastomogenic substances in the development of leukemias in the newborn and yound children is discussed.