[Hypophyseal hormones in young patients with breast cancer]. / Gipofizarnye gormony u bolnykh rakom molochnoi zhelezy molodogo vozrasta.

Hypophyseal hormones were studied in comparison with cellular and humoral immunity in young and middle aged females with breast cancer and controls matched by age. No correlation existed between LH concentrations and cellular, humoral immunological parameters in young breast cancer patients. Basal secretion of FSH directly correlated with the activation markers expression (antigens CD30, CD38) only in young patients. Prolactin concentration was negatively related to B-cell marker (mu-chain IgM) and expression of adhesion molecules (antigen CD11b) in the young, while in the middle-aged to mature T-cell levels only (antigen CD3). No age-specific correlations were found between immunological parameters and ACTH basal secretion, except direct relationship with CD11b-positive cells expression in middle-aged subjects.

[Estradiol-17beta, sex steroid-binding globulin and the cellular and humoral immunity indices in young women with breast cancer]. / Estradiol-17beta, polovye steroidy sviazyvaiushchii globulin i nekotorye pokazateli kletochnogo i gumoral'nogo immuniteta u molodykh zhenshchin, bol'nykh rakom molochnoi zhelezy.

Blood serum levels of sex steroid-binding globulin (SSBG), free and SSBG- and albumin-binding fractions of estradiol-17 beta as well as some indexes of cellular and humoral immunity were compared in 25 young female patients with stage 1-3 breast cancer and controls. No significant difference in SSBG and free estradiol-17 beta fraction as well as free estrogen index was established between patients and controls. In the patient group, a direct correlation was established between free estradiol-17 beta fraction level and that of mature T-cells expressing CD3 antigen and between SSBG level, on the one hand, and total level of T-cells (CD7 antigen) and that of T-suppressors (CD8 antigen-containing cytotoxic lymphocytes), on the other. An inverse correlation was established in the same group between SSBG level and that of B-cell markers expressing CD3 and 7 antigens and IgM mu-chain. In the follicular and lutein phases of the menstrual cycle, a difference in the degree of correlation between total estradiol-17 beta level and immunologic indexes was established between breast cancer patients and controls.

[The lymphocyte immunological phenotype of young and middle-aged breast cancer patients]. / Immunologicheskii fenotip limfotsitov u bol'nykh rakom molochnoi zhelezy molodogo i srednego vozrasta.

The immunologic phenotype of lymphocytes of young and middle-aged patients with breast cancer was identified using ICO monoclonal antibodies. The parameters were compared to that of healthy subjects of the corresponding age groups. Breast cancer patients of both age groups were shown to have lower T-cell level as compared to donors. Parameters of T-cell-mediated immunity did not differ significantly between the young and middle-aged patients, although the former group tended to have lower level of mature T-lymphocytes. A significant decrease in parameters of B-cell-mediated immunity was observed in young patients as compared to donors whereas in middle-aged patients B-lymphocyte and monocyte levels were 4 times those in donors. B-lymphocyte level in young patients tended to be lower than in middle-aged ones.

[Prognosis in patients with malignant fibrous histiocytoma of the soft tissues]. / Prognoz u bol'nykh so zlokachestvennoi fibroznoi gistotsitomoi miagkikh tkanei.

The paper deals with a retrospective clinico-anatomical study in 108 cases of malignant fibrous histiocytoma which identified 18 factors influencing the development of recurrences and metastases as well as survival. Computed data were used to form groups suitable for establishing individual prognosis. The latter was done by summing up the relevant specifically-numbered factors. Credibility for prognosis of recurrence development was 85.7%, metastatic development--82.9, three-year survival--71.4 and five-year survival--95.8%.

[Clinical characteristics of a malignant fibrous histiocytoma of the soft tissues]. / Klinicheskaia kharakteristika zlokachestvennoi fibroznoi gistiotsitomy miagkikh tkanei.

The results of a study of 51 cases of malignant fibrous histiocytoma of soft tissues are discussed. The survival versus clinico-morphological feature correlation was studied. Shorter survival time was found to be associated with pain syndrome and tumor-produced skin symptoms as well as in cases of tumor misdiagnosed as hematoma. Female patients over 50 years showed relatively longer survival time. No correlation was established between survival time and histological pattern of tumor.