Assuntos
Endossonografia/métodos , Mucosa Gástrica/patologia , Gastroscopia/métodos , Neoplasias Gástricas/diagnóstico , Corantes , Mucosa Gástrica/cirurgia , Humanos , Índigo Carmim , Estadiamento de Neoplasias , Neoplasias Gástricas/diagnóstico por imagem , Neoplasias Gástricas/patologia , Neoplasias Gástricas/cirurgiaRESUMO
To compare intraluminal ultrasonographic (ILUS) findings with histological findings of rectal carcinoid tumors, 35 patients with rectal carcinoid tumors were reviewed. The results were as follows: 1) The rectal wall was visualized as a seven- or nine-layer structure by means of ILUS in 81% of the patients. 2) The possibility that the thin hyperechoic third layer above the tumor on ILUS corresponds to the muscularis mucosae and fibrointerstitium above the tumor histologically. 3) In cases with relatively high internal echoes, the amount of fibrointerstitium exceeded that of tumor cells histologically. 4) In cases with nonuniform internal echo patterns, tumor cells were separated by thick fibrointerstitium forming nodular nests.
Assuntos
Tumor Carcinoide/diagnóstico por imagem , Neoplasias Retais/diagnóstico por imagem , Tumor Carcinoide/patologia , Humanos , Métodos , Neoplasias Retais/patologia , UltrassonografiaRESUMO
The detectability of superficial-type carcinoma of the gallbladder by ultrasonography (US) and endoscopic ultrasonography (EUS) were investigated. Eight patients with such carcinoma of the gallbladder were reviewed. They had undergone both US and EUS previous to surgery. The tumor was detected in 3 patients by US, 2 patients with IIa + IIb-type carcinoma and 1 patient with IIa-type carcinoma. Those lesions were visualized as localized thickening of the gallbladder wall or as broad-based tumor. In 2 patients, lesions were not initially detected by US, but were shown by US after the examination by EUS. The tumor was detected by EUS also in 1 case of IIb + IIa-type carcinoma besides those 3 patients mentioned above. All four of these lesions were visualized as broad-based tumor by EUS. It was difficult to detect pure IIb-type or small IIa-type carcinoma even by EUS. In patients with concomitant acute cholecystitis or gallbladder stone, it was difficult to evaluate the abnormal findings of the gallbladder wall.
Assuntos
Carcinoma/diagnóstico por imagem , Endoscopia , Neoplasias da Vesícula Biliar/diagnóstico por imagem , Ultrassonografia de Intervenção/métodos , Idoso , Carcinoma/patologia , Feminino , Neoplasias da Vesícula Biliar/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Estudos RetrospectivosRESUMO
The optimal dose of cisplatin (CDDP) for combination chemotherapy for the treatment of inoperable, advanced gastric cancer has yet to be established. We therefore performed a randomized study to compare the therapeutic usefulness of two dose levels of cisplatin. 5'-deoxy-5-fluorouridine (5'-DFUR 1,400 mg/m(2)/d) was given orally on days 1 to 4 and 15 to 18. Mitomycin C (MMC, 5.75 mg/m(2)/d) was injected intravenously on day 5. In addition, 80 mg/m2/d of CDDP (regimen A) or 60 mg/m(2)/d of CDDP (regimen B) was given by 2-h intravenous drip infusion on day 5. This treatment cycle was repeated every four weeks. Fifty-six patients were enrolled. Clinical response was evaluated in 32 patients (regimen A, 16 patients; regimen B? 16 patients) with measurable lesions. The response rate was significantly higher with regimen A (9 PR/16, 56.3%) than with regimen B (3 PR/16, 18.9%) (p=0.028, chi(2) test). Median survival was slightly but not significantly longer with regimen A (7.4 months) than with regimen B (6.3 months). Drug toxicity included myelosuppression and gastrointestinal symptoms, but there were no serious adverse reactions or differences in safety between the treatment regimens. Regimen A was associated with a high response rate and low toxicity. The optimal dose of CDDP in combination with 5'-DFUR and MMC for the treatment of advanced gastric cancer is regarded to be 80 mg/m(2).
Assuntos
Cisto Pancreático/diagnóstico , Neoplasias Pancreáticas/diagnóstico , Diagnóstico Diferencial , Humanos , Masculino , Pessoa de Meia-Idade , Cisto Pancreático/diagnóstico por imagem , Cisto Pancreático/patologia , Neoplasias Pancreáticas/diagnóstico por imagem , Neoplasias Pancreáticas/patologia , UltrassonografiaAssuntos
Adenocarcinoma Mucinoso/metabolismo , Adenocarcinoma Papilar/metabolismo , Mucinas/biossíntese , Neoplasias Pancreáticas/metabolismo , Adenocarcinoma Mucinoso/patologia , Adenocarcinoma Papilar/patologia , Idoso , Idoso de 80 Anos ou mais , Duodeno/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica , Neoplasias Pancreáticas/patologia , Estômago/patologiaRESUMO
Thirty-six cases of pancreatic cancer including 27 cases of so-called mucin producing cancer of the pancreas, examined with endoscopic ultrasonography (EUS) and treated with surgery, were reviewed to evaluate the usefulness of EUS in the diagnosis of portal venous (PV) invasion. The detection rate of pancreatic tumors cancer by EUS was 92% in 36 cases. The detection rate of PV invasion by EUS was compared with histological results in each case. Judgement of the correlation between the tumor and the PV wall was possible in 30 cases (83%), and the overall accuracy of EUS in the diagnosis of PV invasion was 73%. It is concluded that EUS is a very useful method for diagnosis of PV invasion in cases of pancreatic cancer.