RESUMO
Six prenyl (=3-methylbut-2-en-1-yl) chalcones (=1,3-diphenylprop-2-en-1-ones), 2-7, and one natural non-prenylated chalcone, 1, have been synthesized and evaluated for their in vitro growth-inhibitory activity against three human tumor cell lines. A pronounced dose-dependent growth-inhibitory effect was observed for all prenylated derivatives, except for 7. The chalcone possessing one prenyloxy group at C(2'), i.e., 2, was the most active derivative against the three human tumor cell lines (5.9Assuntos
Apoptose/efeitos dos fármacos
, Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
, Chalcona/análogos & derivados
, Linhagem Celular Tumoral
, Chalcona/síntese química
, Chalcona/toxicidade
, Ensaios de Seleção de Medicamentos Antitumorais
, Humanos
, Estereoisomerismo