RESUMO
The efficacy of continuous and intermittent nitroglycerin patches (10 mg/day) was compared in a randomized, placebo-controlled trial in 36 patients with stable angina and reproducible, exercise-induced ST depression. Intermittent treatment was administered either 18 or 14 h/day with an intermission of 6 h or 10 h, respectively. Exercise tests were performed during the last 2 h of patch application. Compared with placebo, neither continuous nitroglycerin nor the two intermittent regimens prolonged total treadmill time or time to 1 mm ST depression. No treatment eliminated exercise-induced ST depression in greater than 1 of the 36 patients. Time to angina was prolonged (by 40 +/- 66 s) only during the "10 h off" treatment (p = 0.001); time to angina increased by greater than or equal to 20% in 13 patients. Responders to treatment could be predicted by a short history of angina (p less than 0.05) and a time to angina less than or equal to 250 s during the placebo test. For each treatment, greater than or equal to 25 of the patients reported headache; 4 additional patients dropped out because of severe headache and 2 others because of a coronary event in a washout period. Thus, in most patients with stable angina, side effects outweight any benefit demonstrable with this therapy.
Assuntos
Angina Pectoris/tratamento farmacológico , Nitroglicerina/administração & dosagem , Administração Cutânea , Adulto , Idoso , Angina Pectoris/fisiopatologia , Eletrocardiografia , Teste de Esforço , Feminino , Cefaleia/induzido quimicamente , Humanos , Masculino , Pessoa de Meia-Idade , Nitroglicerina/efeitos adversosAssuntos
Circulação Colateral , Circulação Coronária , Doença das Coronárias/prevenção & controle , Esforço Físico , Aptidão Física , Adulto , Peso Corporal , Colesterol/sangue , Angiografia Coronária , Doença das Coronárias/diagnóstico por imagem , Doença das Coronárias/fisiopatologia , Teste de Esforço , Humanos , Masculino , Pessoa de Meia-Idade , Dobras Cutâneas , Triglicerídeos/sangueRESUMO
One hundred and sixty-five middle-aged, apparently normal men were submitted to a six-month conditioning program. On the basis of a casual blood pressure measurement during the pre-training evaluation, 37 individuals (23%) were classified as "borderline" hypertensive. The remaining subjects (n = 128) were normotensive. At the conclusion of the program both groups exhibited significant reductions in systolic and diastolic blood pressures at rest and after submaximal work. Moreover, the reductions of the resting systolic and diastolic and of the exercise (300 kg.m./min.) systolic blood pressures were significantly greater for the hypertensives.
Assuntos
Hipertensão/prevenção & controle , Educação Física e Treinamento , Adulto , Pressão Sanguínea , Estatura , Peso Corporal , Eletrocardiografia , Teste de Esforço , Frequência Cardíaca , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
A study was undertaken to investigate whether a physical training effect could be observed in the adipose tissue composition of coronary patients. The results indicated that there was an increase in the proportion of palmitic acid and a decrease in oleic acid. These changes were accompanied by an increase in blood cholesterol.