Assuntos
Dor Abdominal/etiologia , Diarreia/etiologia , Vasculite por IgA/complicações , Vasculite por IgA/tratamento farmacológico , Imunossupressores/uso terapêutico , Ácido Micofenólico/análogos & derivados , Criança , Humanos , Masculino , Ácido Micofenólico/uso terapêutico , Recidiva , Resultado do TratamentoAssuntos
Dor Abdominal/etiologia , Artrite/etiologia , Exantema/etiologia , Granulomatose com Poliangiite/complicações , Granulomatose com Poliangiite/diagnóstico , Adolescente , Anti-Inflamatórios/uso terapêutico , Antirreumáticos/uso terapêutico , Azatioprina/uso terapêutico , Ciclofosfamida/uso terapêutico , Diagnóstico Diferencial , Feminino , Granulomatose com Poliangiite/terapia , Hemoptise/etiologia , Humanos , Imunossupressores/uso terapêutico , Hemissuccinato de Metilprednisolona/uso terapêutico , Plasmaferese , Prednisona/uso terapêutico , Rituximab/uso terapêuticoRESUMO
BACKGROUND: Benzo[a]pyrene (BaP) is one of the most potent carcinogens generated in cigarette smoke. During smoking, cigarette filters trap a significant portion of mainstream smoke benzo[a]pyrene. This trapped portion is proportional to what exits the end of the filter and is drawn into the mouth of smokers. METHODS: We developed a new method to estimate mouth-level BaP intake using filter analysis. In this analysis, cigarettes are smoked by a smoking machine using a variety of conditions to yield a range of mainstream smoke deliveries, which approximate a range of human puffing characteristics. Mainstream smoke BaP collected on Cambridge filter pads and the corresponding 1-cm mouth-end cigarette filter butts is extracted, purified by solid-phase extraction, and quantified by high-performance liquid chromatography coupled with a fluorescence detector. On the basis of the amount of BaP retained in cigarette butts and the amount collected on pads, we can relate them using a linear regression model. RESULTS: Using this model and subsequently analyzing cigarette filters collected from smokers, we are able to estimate their mouth-level intakes, which smokers received when they consumed cigarettes. We made a series of measurements using research cigarettes and select commercial cigarettes having a wide range of machine smoke "tar" and nicotine deliveries. CONCLUSIONS: In all cases, results indicate a linear relation of BaP between cigarette filter butts and Cambridge filter pads, with R(2) ranging from 0.93 to 0.98. IMPACT: This technique provides a noninvasive means to examine intake on a per cigarette basis to examine both exposure and behavioral aspects of smoking.