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1.
Magn Reson Med ; 86(1): 442-455, 2021 07.
Artigo em Inglês | MEDLINE | ID: mdl-33543788

RESUMO

PURPOSE: Increased arterial stiffness has been shown to be one of the earliest markers of cerebrovascular dysfunction. As a surrogate marker of arterial stiffness, pulse wave velocity (PWV) quantifications are generally carried out on central and peripheral arteries. The purpose of this study was to develop and evaluate an MRI approach to assess carotid stiffness by measuring carotid PWV (cPWV) using a fast oblique-sagittal phase-contrast MRI sequence. METHODS: In 29 volunteers, a single-slice oblique-sagittal phase-contrast MRI sequence with retrospective cardiac gating was used to quantify blood velocity waveforms along a vessel segment covering the common carotid artery (CCA) and the internal carotid artery (ICA). The CCA-ICA segment length was measured from a region of interest selected on the magnitude image. Phase-contrast MRI-measured velocities were also used to quantify the ICA pulsatility index along with cPWV quantification. RESULTS: The mean value of cPWV calculated using the middle upslope area algorithm was 2.86 ± 0.71 and 3.97 ± 1.14 m/s in young and elderly subjects, respectively. Oblique-sagittal phase-contrast MRI-derived cPWV measurements showed excellent intrascan and interscan repeatability. cPWV and ICA pulsatility index were significantly greater in older subjects compared to those in the young subjects (P < .01 and P = .01, respectively). Also, increased cPWV values were associated with elevated systolic blood pressure (ß = 0.05, P = .03). CONCLUSION: This study demonstrated that oblique-sagittal phase-contrast MRI is a feasible technique for the quantification of both cPWV and ICA pulsatility index and showed their potential utility in evaluating cerebroarterial aging and age-related neurovascular disorders.


Assuntos
Análise de Onda de Pulso , Rigidez Vascular , Idoso , Velocidade do Fluxo Sanguíneo , Artérias Carótidas/diagnóstico por imagem , Humanos , Imageamento por Ressonância Magnética , Estudos Retrospectivos
2.
Brain Behav ; 2(4): 435-42, 2012 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-22950047

RESUMO

Hippocampal sclerosis (HS) is a common and often asymmetric neuropathological finding among elderly persons who experience progressive memory loss, but its cause is unknown and it is rarely diagnosed during life. In order to improve both understanding and diagnosis of late-life HS, bilateral hippocampi and cerebral hemispheres were reviewed in 130 consecutive autopsy cases drawn from a longitudinal study of subjects with subcortical ischemic vascular dementia (IVD), Alzheimer disease (AD) and normal aging. HS was found in 31 of 130 cases (24.5%). Of these, 45% were bilateral, 32% left-sided, and 23% right-sided. The majority of HS cases involved the entire rostral-caudal extent of the hippocampus. However, in 7 cases HS was focal in nature and was only found at or anterior to the lateral geniculate nucleus. In 77% of cases, HS was accompanied by other types of pathology ('mixed' HS), but in 23% of cases it was the sole neuropathologic finding ('pure' HS). TDP-43-positive cytoplasmic inclusions were found in dentate granule cells in 93% of all HS cases, 55% of AD cases with no HS, but 0% of IVD cases with no HS. MRI hippocampal volumes were significantly lower in bilateral HS compared to AD (p < 0.001) and in unilateral HS cases compared to cases with intact hippocampi (p < 0.001). Since HS may occur unilaterally in approximately a quarter of cases, its prevalence may be underestimated if only one cerebral hemisphere is examined. The presence of TDP-43 inclusions in HS cases, regardless of accompanying pathologies (e.g., AD, IVD, FTLD), is consistent with an underlying neurodegenerative pathogenetic mechanism. Further studies are warranted to determine whether greater severity of hippocampal atrophy on MRI may assist the clinical differentiation of HS from AD.

3.
Alzheimers Dement ; 2(3): 185-94, 2006 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-19595882

RESUMO

Vascular cognitive impairment (VCI) is the phenotypic outcome of a cascade of events: vascular risk factors lead to vascular disease, which causes vascular brain injury (VBI) in networks important for cognition. Both VCI and Alzheimer's disease (AD) increase exponentially with age, and their interactions are common and controversial. The ability of current consensus criteria to distinguish VCI from AD is limited. Currently, the primary and secondary prevention of VCI is essentially the same for stroke, whereas symptomatic treatment of VCI is similar to AD. An emerging database suggests that VBI contributes significantly to mild VCI and can accelerate the appearance of dementia when AD pathology is mild. Early evidence suggests that the adverse effects of VBI are submerged once AD pathology spreads into isocortex. Recently, epidemiologic studies reported associations between vascular risk factors and clinically diagnosed AD as well as stroke. If hypertension, diabetes, and hyperlipidemia truly accelerate beta-amyloidosis and tauopathy, as well as VBI, the importance of their early identification and treatment will be greatly magnified.

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