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1.
Obstet Gynecol ; 141(6): 1199-1202, 2023 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-37141599

RESUMO

We examined differences in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody responses in pregnant individuals with natural, vaccine-induced, or combined immunity. Participants had live or nonlive births between 2020 and 2022, were seropositive (SARS-CoV-2 spike protein, anti-S), and had available mRNA vaccination and infection information (n=260). We compared titer levels among three immunity profiles: 1) natural immunity (n=191), 2) vaccine-induced immunity (n=37), and 3) combined immunity (ie, natural and vaccine-induced immunity; n=32). We applied linear regression to compare anti-S titers between the groups, controlling for age, race and ethnicity, and time between vaccination or infection (whichever came last) and sample collection. Anti-S titers were 57.3% and 94.4% lower among those with vaccine-induced and natural immunity, respectively, compared with those with combined immunity ( P <.001, P =.005).


Assuntos
Vacinas contra COVID-19 , COVID-19 , Complicações Infecciosas na Gravidez , Feminino , Humanos , Gravidez , Anticorpos Antivirais , COVID-19/prevenção & controle , Complicações Infecciosas na Gravidez/prevenção & controle , SARS-CoV-2 , Vacinação , Vacinas contra COVID-19/administração & dosagem
2.
Vaccine ; 41(3): 649-656, 2023 01 16.
Artigo em Inglês | MEDLINE | ID: mdl-36526507

RESUMO

Research suggest prenatal vaccination against coronavirus disease-19 (COVID-19) is safe. However, previous studies utilized retrospectively collected data or examined late pregnancy vaccinations. We investigated the associations of COVID-19 vaccination throughout pregnancy with delivery and neonatal outcomes. We included 1,794 mother-neonate dyads enrolled in the Generation C Study with known prenatal COVID-19 vaccination status and complete covariate and outcome data. We used multivariable quantile regressions to estimate the effect of prenatal COVID-19 vaccination on birthweight, delivery gestational age, and blood loss at delivery; and Poisson generalized linear models for Caesarean delivery (CD) and Neonatal Intensive Care Unit (NICU) admission. Using the above methods, we estimated effects of trimester of vaccine initiation on these outcomes. In our sample, 13.7% (n = 250) received at least one prenatal dose of any COVID-19 vaccine. Vaccination was not associated with birthweight (ß = 12.42 g [-90.5, 114.8]), gestational age (ß = 0.2 days [-1.1, 1.5]), blood loss (ß = -50.6 ml [-107.0, 5.8]), the risks of CD (RR = 0.8; [0.6, 1.1]) or NICU admission (RR = 0.9 [0.5, 1.7]). Trimester of vaccine initiation was also not associated with these outcomes. Our findings suggest that there is no associated risk between prenatal COVID-19 vaccination and adverse delivery and neonatal outcomes in a cohort sample from NYC.


Assuntos
Vacinas contra COVID-19 , COVID-19 , Resultado da Gravidez , Feminino , Humanos , Recém-Nascido , Gravidez , Peso ao Nascer , COVID-19/prevenção & controle , Vacinas contra COVID-19/efeitos adversos , Cidade de Nova Iorque/epidemiologia , Estudos Retrospectivos
3.
J Can Chiropr Assoc ; 67(3): 202-225, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-38283160

RESUMO

Objectives: To investigate the research capacity and productivity of Canadian sports chiropractors. Methods: A cross-sectional survey (phase one) and scoping review (phase two) investigated the research capacity and productivity (from 2015-2020) of the Canadian sports chiropractic field. Results: Most respondents (72%) reported obtaining research training from fellowship and master's programs, with only 2 (1%) PhD qualifications identified. Approximately, 30% reported active involvement in research, with 28% being part-time clinician researchers. Access to human and technological research resources were limited. We identified 67 publications and 16 conference presentations within a five-year period, with clinical, population health, and basic science research as the areas most studied. Conclusion: The research effort of Canadian sports chiropractors is primarily conducted by clinicians involved in research on a part-time basis. Its research outputs predominantly reflect the research requirements of the RCCSS(C) Sports Sciences Residency Program, highlighting its contribution in developing capacity and producing research for the Canadian sports chiropractic field.


Objectifs: Étudier la capacité de recherche et la productivité des chiropraticiens du sport Canadiens. Méthodes: Une enquête transversale (première phase) et un examen de la portée (deuxième phase) ont permis d'étudier la capacité de recherche et la productivité (de 2015 à 2020) du domaine de la chiropratique sportive au Canada. Résultats: La plupart des répondants (72 %) ont déclaré avoir obtenu une formation en recherche dans le cadre de programmes de bourses et de maîtrises, et seulement 2 (1 %) ont indiqué avoir obtenu un doctorat. Environ 30 % des répondants ont déclaré participer activement à la recherche, 28 % d'entre eux étant des cliniciens-chercheurs à temps partiel. L'accès aux ressources humaines et technologiques de la recherche était limité. Nous avons recensé 67 publications et 16 présentations de conférences sur une période de cinq ans, les domaines les plus étudiés étant la recherche clinique, la recherche sur la santé des populations et la recherche en sciences fondamentales. Conclusion: L'effort de recherche des chiropraticiens du sport canadiens est principalement mené par des cliniciens impliqués dans la recherche à temps partiel. Leurs résultats de recherche reflètent surtout les exigences de recherche du programme de résidence en sciences du sport du Collège royal des sciences chiropratiques du sport du Canada (RCCSS(C)), soulignant leur contribution au développement des capacités et à la production de recherches pour le domaine de la chiropratique du sport au Canada.

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