RESUMO
Erythrocytes deformability, plasma cAMP, 6-keto-PGF1 alpha, TXB2 levels and fibrinolytic activity in patients suffering from arteriosclerosis obliterans before and after Trental were studied. Trental improved the deformability of red cells and resulted in an enhancement of diminished cAMP level in plasma and increased the fibrinolytic activity. The improvement of deformability observed after Trental could depend upon the influence of a higher cAMP level in plasma on the erythrocyte membrane. The increase of cAMP level seems to be the result of the inhibiting effect of Trental on phosphodiesterase and of higher fibrinolytic activity.
Assuntos
Arteriosclerose Obliterante/tratamento farmacológico , Deformação Eritrocítica/efeitos dos fármacos , Pentoxifilina/uso terapêutico , Teobromina/análogos & derivados , 6-Cetoprostaglandina F1 alfa/sangue , Idoso , Arteriosclerose Obliterante/sangue , AMP Cíclico/sangue , Feminino , Fibrinólise/efeitos dos fármacos , Humanos , Masculino , Pessoa de Meia-Idade , Reologia , Tromboxano B2/sangueAssuntos
Anticoagulantes/farmacologia , Arteriosclerose Obliterante/sangue , Hidroxietilrutosídeo/análogos & derivados , Leucócitos/efeitos dos fármacos , Rutina/análogos & derivados , Idoso , Arteriosclerose Obliterante/tratamento farmacológico , Adesão Celular/efeitos dos fármacos , Feminino , Humanos , Hidroxietilrutosídeo/farmacologia , Perna (Membro)/irrigação sanguínea , Masculino , Pessoa de Meia-IdadeRESUMO
Deformability of red cells and plasma levels of cAMP and cGMP were studied in patients with arteriosclerosis obliterans of lower limbs. Deformability of red cells and plasma levels of cAMP were found to be decreased in these patients. Venous injection of HR (Venoruton) in one dose (1,000 mg) to patients, led to an increase of red cell deformability and normalisation of cAMP plasma level. The plasma level of cGMP was not changed. The beneficial effect of HR in arteriosclerosis obliterans depends, first of all, on improving the deformability of red cells. The decreased deformability observed in arteriosclerosis seems to be a result of disturbances in the rate of spectrin phosphorylation of the erythrocyte membrane. By normalising the plasma level of cAMP HR had a considerable influence on the appropriate state of elasticity of the red cell membrane.