RESUMO
BACKGROUND: In adults, obesity is associated with abnormalities of thyroid function; there are fewer studies in paediatric cohorts. OBJECTIVES: To examine associations of weight and adiposity with indices of thyroid function and thyroid-related metabolic factors in children. DESIGN/METHODS: A sample of 1203 children without obesity (body mass index [BMI] < 95th percentile; N = 631) and with obesity (BMI ≥ 95th percentile; N = 572), age 5-18 years, had height and weight measured (to calculate BMI-Z score for age and sex) and had blood collected in the morning for thyroid-stimulating hormone (TSH), free thyroxine (FT4) and leptin. A subset (N = 829) also underwent measurement of fat mass by dual-energy X-ray absorptiometry. Analyses examined associations of TSH and FT4 with adiposity and obesity-related conditions accounting for sociodemographic factors. RESULTS: Thyroid-stimulating hormone was positively related to BMIz and fat mass (both p-values < 0.001). FT4 was negatively related to BMIz and fat mass (both p-values < 0.001). TSH was positively correlated to leptin (p = 0.001) even after accounting for fat mass. CONCLUSIONS: Paediatric obesity is associated with higher TSH and lower FT4 concentrations and with a greater prevalence of abnormally high TSH. Leptin concentrations may in part explain obesity's effects on thyroid status, perhaps through leptin's effects on TSH secretion.
Assuntos
Adiposidade/fisiologia , Leptina/sangue , Obesidade Infantil/fisiopatologia , Glândula Tireoide/fisiopatologia , Tireotropina/sangue , Tiroxina/sangue , Absorciometria de Fóton , Adolescente , Índice de Massa Corporal , Peso Corporal , Criança , Feminino , Humanos , MasculinoAssuntos
Púrpura Trombocitopênica Idiopática , Trombopoese , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Púrpura Trombocitopênica Idiopática/tratamento farmacológico , Púrpura Trombocitopênica Idiopática/imunologia , Púrpura Trombocitopênica Idiopática/metabolismo , Receptores de Trombopoetina/agonistasAssuntos
Café , Preferências Alimentares , Temperatura , Adolescente , Adulto , Idoso , Feminino , Aromatizantes , Humanos , Masculino , Pessoa de Meia-Idade , Transtornos Relacionados ao Uso de SubstânciasRESUMO
This experiment employed a 2 x 2 design in which the nutritional and early stimulation conditions of rat pups were manipulated during the 1st 3 weeks of postnatal life. Animals were observed in various open field activities at 22, 23, 29, 36, and 50 days of age, and killed at 55 days of age for neurochemical analysis. Early handling decreased the behavioral differences due to malnutrition and resulted in fewer, but larger cells in rat forebrain for both well-nourished and malnourished groups.
