RESUMO
OBJECTIVE: To evaluate nuchal translucency measurement quality assurance techniques in a large-scale study. METHODS: From 1999 to 2001, unselected patients with singleton gestations between 10 + 3 weeks and 13 + 6 weeks were recruited from 15 centers. Sonographic nuchal translucency measurement was performed by trained technicians. Four levels of quality assurance were employed: (1) a standardized protocol utilized by each sonographer; (2) local-image review by a second sonographer; (3) central-image scoring by a single physician; and (4) epidemiological monitoring of all accepted nuchal translucency measurements cross-sectionally and over time. RESULTS: Detailed quality assessment was available for 37 018 patients. Nuchal translucency measurement was successful in 96.3% of women. Local reviewers rejected 0.8% of images, and the single central physician reviewer rejected a further 2.9%. Multivariate analysis indicated that higher body mass index, earlier gestational age and transvaginal probe use were predictors of failure of nuchal translucency measurement and central image rejection (P = 0.001). Epidemiological monitoring identified a drift in measurements over time. CONCLUSION: Despite initial training and continuous image review, changes in nuchal translucency measurements occur over time. To maintain screening accuracy, ongoing quality assessment is needed.
Assuntos
Síndrome de Down/diagnóstico por imagem , Medição da Translucência Nucal/normas , Garantia da Qualidade dos Cuidados de Saúde/métodos , Adulto , Feminino , Humanos , Programas de Rastreamento , Gravidez , Primeiro Trimestre da Gravidez , Segundo Trimestre da Gravidez , Adulto JovemRESUMO
Both pulmonary lymphangioleiomyomatosis and tuberous sclerosis are rare diseases. The optimal management in pregnancy is unclear. A primigravida with pulmonary lymphangioleiomyomatosis and tuberous sclerosis complicated by worsening renal function secondary to angiomyolipomas was managed conservatively. Favorable maternal and neonatal outcomes were achieved. Pulmonary lymphangioleiomyomatosis is a consideration in tuberous sclerosis patients with respiratory symptoms. Tuberous sclerosis patients with pulmonary lymphangioleiomyomatosis require cautious and calculated expectant management in an effort to avoid adverse outcomes.
Assuntos
Angiomiolipoma/complicações , Neoplasias Renais/complicações , Neoplasias Pulmonares/complicações , Linfangioleiomiomatose/complicações , Complicações na Gravidez/terapia , Esclerose Tuberosa/complicações , Adulto , Angiomiolipoma/terapia , Feminino , Humanos , Neoplasias Renais/terapia , Neoplasias Pulmonares/terapia , Linfangioleiomiomatose/terapia , GravidezRESUMO
OBJECTIVE: To assess the obstetric and urological outcomes during and after pregnancy following urinary tract reconstruction, as pregnancies after such surgery can have a significant effect on the function of the reconstructed urinary tract, and the reconstruction can significantly affect the delivery of the fetus. PATIENTS AND METHODS: We retrospectively reviewed the obstetric and urological history of 11 patients (12 pregnancies; 10 singletons and one twin) with previous urinary reconstruction, delivered between 1989 and 2003. Antepartum and postpartum urological function and obstetric outcomes were investigated. RESULTS: All the patients had some difficulty with clean intermittent catheterization (CIC) during pregnancy, and four needed continuous indwelling catheters. During pregnancy 10 women had several bladder infections and all received antibiotic suppression. There were eight Caesarean sections, two vaginal deliveries and one combined delivery. Six Caesareans were elective and three were emergent. The use of CIC returned to normal in all patients after delivery. CONCLUSIONS: Women with a urinary reconstruction can have successful pregnancies. The complexity of the surgery and the concern for possible emergency Caesarean section resulted in most patients having an elective Caesarean delivery before term. Antibiotic prophylaxis is recommended and patients may require indwelling dwelling catheters while pregnant but normal CIC can be resumed after delivery.
Assuntos
Complicações na Gravidez/terapia , Derivação Urinária , Doenças Urológicas/cirurgia , Adulto , Cesárea/estatística & dados numéricos , Feminino , Humanos , Gravidez , Resultado da Gravidez , Cuidado Pré-Natal/métodos , Cuidados Pré-Operatórios/métodos , Estudos RetrospectivosRESUMO
Verapamil-sensitive idiopathic left ventricular tachycardia is a rare diagnosis. A 31-year-old multiparous woman presented with shortness of breath, palpitations and new-onset, wide complex tachycardia at approximately 28 weeks' gestation. Multiple antiarrhythmic agents were administered without resolution of the arrhythmia. Verapamil-sensitive idiopathic left ventricular tachycardia was diagnosed on the basis of a fusion beat with a right bundle branch pattern, a pathognomonic finding, which was noted on an electrocardiogram. Verapamil resulted in conversion to normal sinus rhythm. The patient delivered at term uneventfully. To our knowledge, this is the first description of verapamil-sensitive idiopathic left ventricular tachycardia in pregnancy. The case illustrates that the origin of wide complex tachyarrhythmias should be identified to provide the proper treatment expeditiously.
Assuntos
Antiarrítmicos/uso terapêutico , Complicações na Gravidez/diagnóstico , Complicações na Gravidez/tratamento farmacológico , Taquicardia Ventricular/diagnóstico , Taquicardia Ventricular/tratamento farmacológico , Verapamil/uso terapêutico , Adulto , Diagnóstico Diferencial , Eletrocardiografia , Feminino , Humanos , Gravidez , Terceiro Trimestre da Gravidez , Diagnóstico Pré-NatalRESUMO
OBJECTIVE: The purpose of this study was to evaluate the use of the TDx-FLM fluorescence polarization assay on vaginal pool fluid in patients with preterm premature rupture of membranes (PPROM). METHODS: A prospective matched-pairs study was performed at a tertiary care center. For each patient enrolled, amniotic fluid samples were obtained by sterile speculum examination and by amniocentesis within 12 h of each other. Inclusion criteria were the presence of PPROM and a gestational age of 30-36 weeks. The samples were analyzed separately using the TDx-FLM assay in the same laboratory. The results were compared using a paired Student t test. RESULTS: A total of 16 patients received both amniocentesis and vaginal collection of amniotic fluid. The mean gestational age at amniocentesis was 33.3 weeks (SD 1.9). In every case, the vaginal pool TDx-FLM result was lower than the amniocentesis result. The mean difference in the assays between the two fluid sources was 35% (range 17-63%, p < 0.001). Amniocentesis suggested a mature result in 12 cases (75%), an indeterminate result in two cases (12.5%), and an immature result in two cases (12.5%). Vaginal pool fluid suggested a mature result in four cases (25%), an indeterminate result in nine cases (56%), and an immature result in three cases (19%). Using the cut-off values validated for amniocentesis specimens as a standard for comparison, vaginal pool TDx-FLM assay had 42% sensitivity, 100% specificity, 100% positive predictive value and 36% negative predictive value for predicting lung maturity. CONCLUSIONS: The TDx-FLM assay on vaginal pool samples of amniotic fluid yielded results that were significantly different from those of amniocentesis samples. At this point, the assay is only clinically useful for vaginal pool samples when a mature result is obtained.