RESUMO
Lyophilised decoction (10%) of the leaves of Bridelia atroviridis Muell. Arg. (Euphorbiaceae) was studied in the rat cardiovascular system. In vivo, the extract (15 and 30 mg/kg) caused a decrease of arterial pressure and a decrease of heart rate in an anaesthetized rat (ethylcarbamate 1.2 g/kg). If administrations of Bridelia were repeated (three times) a tachyphylaxie phenomena was observed. After administrations of adrenaline, noradrenaline, acethylcholine and isoprenaline the extract had no effect on the action of these neuromediators on blood pressure. In vitro the extract induced dose-dependent negative inotropic and chronotropic effects in isolated rat heart. It was ineffective in rat aorta preparations. Bridelia seemed to have a direct effect on rat heart. Hypotension is not due to an action on the vessels. The extract did not appear to interact with adrenergic nor cholinergic receptors. However, the extract was able to potentiate barium chloride induced contractions of rat aorta preparations. The extract might act through potential dependent calcium channels.
Assuntos
Pressão Sanguínea/efeitos dos fármacos , Frequência Cardíaca/efeitos dos fármacos , Coração/efeitos dos fármacos , Contração Miocárdica/efeitos dos fármacos , Neurotransmissores/antagonistas & inibidores , Extratos Vegetais/farmacologia , Receptores Adrenérgicos/efeitos dos fármacos , Receptores Colinérgicos/efeitos dos fármacos , Animais , Aorta/efeitos dos fármacos , Aorta/metabolismo , Canais de Cálcio/efeitos dos fármacos , Cardiotônicos/administração & dosagem , Cardiotônicos/farmacologia , Relação Dose-Resposta a Droga , Interações Medicamentosas , Hipotensão/induzido quimicamente , Técnicas In Vitro , Masculino , Medicina Tradicional , Contração Muscular/efeitos dos fármacos , Músculo Liso Vascular/efeitos dos fármacos , Extratos Vegetais/administração & dosagem , Extratos Vegetais/toxicidade , Folhas de Planta , Ratos , Ratos Sprague-Dawley , TaquifilaxiaRESUMO
The study aimed at evidencing the suppressive effect of daily hassles on salivary immunoglobulin A (S-IgA); in fact, previous research did not detect a clear relationship between the two variables. Twenty-four subjects were tested as to the hassles that had occurred in their recent life and to S-IgA; the tests were repeated three times, with an interval of four weeks between each. The results show that the variation of S-IgA values between times 2 and 3 is associated with the variation of hassles between times 1 and 2 (r = -.46, p < .01).
Assuntos
Imunoglobulina A Secretora/análise , Saliva/imunologia , Proteínas e Peptídeos Salivares/análise , Estresse Psicológico/imunologia , Adulto , Feminino , Humanos , Masculino , Testes Psicológicos , Saliva/química , Estudantes de Medicina/psicologiaRESUMO
The research investigated the autogenic training (AT) effects, analyzing the emotional and somatic distress symptoms of patients during their learning of the AT standard exercises (N = 79). An improvement was observed even before the beginning of the course, thus demonstrating the Balint effect of the drug-doctor phenomenon. The control subjects, entered in a waiting list, showed no further improvements from this phase of the study; the experimental ones, who had begun their AT exercises, continued to show significant improvement.
Assuntos
Treinamento Autógeno , Transtornos Psicofisiológicos/prevenção & controle , Estresse Psicológico/psicologia , Adulto , Afeto , Ansiedade/psicologia , Emoções , Feminino , Humanos , Entrevista Psicológica , Masculino , Pessoa de Meia-Idade , Testes Psicológicos , Transtornos Psicofisiológicos/etiologia , Estresse Psicológico/terapiaRESUMO
The effects of the aqueous extract of leaves of Bridelia atroviridis (Bridelia), a small African tree, on the mechanical activity of rat uterus were studied. The aqueous extract of leaves of B atroviridis administered in a concentration-dependent manner (5 x 10(-6)-1.2 x 10(-3) g/ml) induced contractions that were antagonized by various calcium entry blockers (nifedipine, diltiazem, manganese chloride). In absence of external calcium ions, repeated applications of a supramaximal concentration of Bridelia (1.2 x 10(-3) g/ml) evoked sustained and repeated contractions the amplitude of which was congruent to 20% of those obtained in the physiological external calcium concentration. Bridelia-induced contractions in calcium-free medium were inhibited by isoprenaline (8 x 10(-7) M), caffeine (15 x 10(-3) M) and trifluoperazine (10(-5) M). Contractile responses induced by Bridelia in both calcium-containing and calcium-free media were antagonized by prior incubation of uterus with phorbol 12, 13-dibutyrate (6 x 10(-7) M), cholera toxin (6 x 10(-8) M) or pertussis toxin (5 x 10(-7) g/ml). These results show that Bridelia has a potent uterotonic action in the rat. The cellular basis of this action appears to be complex, and involves various mechanisms including calcium mobilization from both intra and extracellular compartments and activation of phospholipase C through a G-protein.
Assuntos
Extratos Vegetais/farmacologia , Contração Uterina/efeitos dos fármacos , Animais , Cálcio/fisiologia , Toxina da Cólera/farmacologia , Relação Dose-Resposta a Droga , Feminino , Técnicas In Vitro , Miométrio/citologia , Miométrio/efeitos dos fármacos , Miométrio/fisiologia , Toxina Pertussis , Dibutirato de 12,13-Forbol/farmacologia , Plantas Medicinais , Ratos , Ratos Endogâmicos , Útero/efeitos dos fármacos , Útero/fisiologia , Fatores de Virulência de Bordetella/farmacologiaRESUMO
The research investigated the autogenic training (AT) immediate effects, analysing the emotional reactions of patients during their learning of the AT standard exercises. An improvement has been observed in all the conditions even before the beginning of the course, thus demonstrating the presence of the drug-doctor-phenomenon; the control subjects, entered in a waiting list, showed no further improvement at this phase of the study.
