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1.
J Neurosurg Sci ; 54(2): 65-9, 2010 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21313957

RESUMO

In recent years, minimally invasive surgical techniques for lumbar fusion and fixation procedures gained worldwide popularity. Herein we describe a personal technique for percutaneous lumbar interbody fusion associated with minimally invasive posterior fixation for patients affected by degenerative disc disease and lumbar instability. The procedure is described in a step-by-step way and early results are presented. Although the present data reflect only an early experience, we believe that this is a straightforward procedure which may be more advantageous in terms of surgical invasiveness, potentially saving operative and recovery time and reducing risks compared to posterior or anterior approaches for lumbar interbody fusion.


Assuntos
Parafusos Ósseos , Degeneração do Disco Intervertebral/cirurgia , Instabilidade Articular/cirurgia , Vértebras Lombares/cirurgia , Procedimentos Cirúrgicos Minimamente Invasivos/métodos , Fusão Vertebral/métodos , Adulto , Idoso , Feminino , Humanos , Fixadores Internos , Masculino , Pessoa de Meia-Idade , Procedimentos Cirúrgicos Minimamente Invasivos/instrumentação , Procedimentos Neurocirúrgicos/instrumentação , Procedimentos Neurocirúrgicos/métodos , Estudos Retrospectivos , Fusão Vertebral/instrumentação , Resultado do Tratamento
2.
Am J Respir Crit Care Med ; 160(2): 711-7, 1999 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-10430750

RESUMO

Previous studies have shown an increased number of inflammatory cells and, in particular, CD8+ve cells in the airways of smokers with chronic obstructive pulmonary disease (COPD). In this study we investigated whether a similar inflammatory process is also present in the lungs, and particularly in lung parenchyma and pulmonary arteries. We examined surgical specimens from three groups of subjects undergoing lung resection for localized pulmonary lesions: nonsmokers (n = 8), asymptomatic smokers with normal lung function (n = 6), and smokers with COPD (n = 10). Alveolar walls and pulmonary arteries were examined with immunohistochemical methods to identify neutrophils, eosinophils, mast cells, macrophages, and CD4+ve and CD8+ve cells. Smokers with COPD had an increased number of CD8+ve cells in both lung parenchyma (p < 0.05) and pulmonary arteries (p < 0.001) as compared with nonsmokers. CD8+ve cells were also increased in pulmonary arteries of smokers with COPD as compared with smokers with normal lung function (p < 0.01). Other inflammatory cells were no different among the three groups. The number of CD8+ve cells in both lung parenchyma and pulmonary arteries was significantly correlated with the degree of airflow limitation in smokers. These results show that an inflammatory process similar to that present in the conducting airways is also present in lung parenchyma and pulmonary arteries of smokers with COPD.


Assuntos
Linfócitos T CD8-Positivos/imunologia , Pneumopatias Obstrutivas/imunologia , Fumar/efeitos adversos , Resistência das Vias Respiratórias/fisiologia , Linfócitos T CD4-Positivos/imunologia , Linfócitos T CD4-Positivos/patologia , Linfócitos T CD8-Positivos/patologia , Eosinófilos/imunologia , Eosinófilos/patologia , Volume Expiratório Forçado/fisiologia , Humanos , Técnicas Imunoenzimáticas , Pulmão/imunologia , Pulmão/patologia , Pneumopatias Obstrutivas/patologia , Neoplasias Pulmonares/imunologia , Neoplasias Pulmonares/patologia , Contagem de Linfócitos , Macrófagos/imunologia , Macrófagos/patologia , Mastócitos/imunologia , Mastócitos/patologia , Neutrófilos/imunologia , Neutrófilos/patologia , Artéria Pulmonar/imunologia , Artéria Pulmonar/patologia
3.
Am J Respir Crit Care Med ; 157(3 Pt 1): 822-6, 1998 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-9517597

RESUMO

To investigate whether the inflammatory process in peripheral airways is different in smokers who develop symptoms of chronic bronchitis and chronic airflow limitation and in asymptomatic smokers who do not develop chronic airflow limitation, we examined surgical specimens obtained from 16 smokers undergoing lung resection for localized pulmonary lesions. Nine had symptoms of chronic bronchitis and chronic airflow limitation and seven were asymptomatic with normal lung function. In peripheral airways, immunohistochemical methods were performed to identify neutrophils, macrophages, CD4+ and CD8+ T-lymphocytes infiltrating the airway wall, and morphometric methods were used to measure the internal perimeter, the airway wall area, and the smooth muscle area. The number of CD8+ T-lymphocytes and the smooth muscle area were increased in smokers with symptoms of chronic bronchitis and chronic airflow limitation as compared with asymptomatic smokers with normal lung function, while the number of neutrophils, macrophages, and CD4+ T-lymphocytes were similar in the two groups of subjects examined. We concluded that smokers who develop symptoms of chronic bronchitis and chronic airflow limitation have an increased number of CD8+ T-lymphocytes and an increased smooth muscle area in the peripheral airways as compared with asymptomatic smokers with normal lung function, supporting the important role of CD8+ T-lymphocytes and airway remodeling in the pathogenesis of chronic obstructive pulmonary disease.


Assuntos
Linfócitos T CD8-Positivos/patologia , Pneumopatias Obstrutivas/patologia , Pulmão/patologia , Fumar/patologia , Idoso , Obstrução das Vias Respiratórias/patologia , Obstrução das Vias Respiratórias/fisiopatologia , Brônquios/patologia , Bronquite/patologia , Bronquite/fisiopatologia , Linfócitos T CD4-Positivos/patologia , Carcinoma/patologia , Carcinoma/cirurgia , Contagem de Células , Doença Crônica , Volume Expiratório Forçado/fisiologia , Humanos , Imuno-Histoquímica , Contagem de Leucócitos , Pulmão/fisiopatologia , Pneumopatias Obstrutivas/fisiopatologia , Neoplasias Pulmonares/patologia , Neoplasias Pulmonares/cirurgia , Contagem de Linfócitos , Macrófagos/patologia , Masculino , Músculo Liso/patologia , Neutrófilos/patologia , Pneumonectomia , Fumar/fisiopatologia , Capacidade Vital/fisiologia
4.
Am J Respir Crit Care Med ; 156(5): 1633-9, 1997 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-9372687

RESUMO

To characterize the inflammatory process in the bronchial glands of smokers with chronic sputum production, we examined lobar bronchi from 18 subjects undergoing lung resection for localized pulmonary lesions, all with a history of cigarette smoking. Nine of the subjects had symptoms of chronic bronchitis and chronic airflow obstruction, and nine were asymptomatic, with normal lung function. The number of neutrophils, eosinophils, mast cells, macrophages, CD4+ and CD8+ T-lymphocytes, and the ratio of CD4+ to CD8+ cells were assessed in the bronchial glands, epithelium, and submucosa. Cells were identified through immunohistochemistry. Smokers with symptoms of chronic bronchitis had an increased number of neutrophils (p = 0.01) and macrophages (p = 0.03) and a decreased CD4+/CD8+ ratio (p = 0.01) in the bronchial glands as compared with asymptomatic smokers. Chronic bronchitic smokers also had an increased number of epithelial neutrophils (p = 0.04), whereas the numbers of macrophages and CD4+ and CD8+ T-lymphocytes in the epithelium and submucosa were similar in the two groups of smokers. No differences in numbers of eosinophils or mast cells were observed between bronchitic and asymptomatic smokers in any of the compartments examined. In conclusion, smokers with chronic sputum production have an increased infiltration of neutrophils and macrophages and an increased proportion of CD8+ T-lymphocytes in their bronchial glands, supporting the important role of bronchial-gland inflammation in the pathogenesis of chronic bronchitis.


Assuntos
Brônquios/patologia , Bronquite/patologia , Glândulas Exócrinas/patologia , Fumar/patologia , Idoso , Idoso de 80 Anos ou mais , Bronquite/etiologia , Bronquite/fisiopatologia , Relação CD4-CD8 , Contagem de Células , Doença Crônica , Eosinófilos/patologia , Epitélio/patologia , Volume Expiratório Forçado , Humanos , Inflamação , Macrófagos/patologia , Masculino , Mastócitos/patologia , Pessoa de Meia-Idade , Mucosa/patologia , Neutrófilos/patologia , Capacidade Vital
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