1.
Nature
; 441(7092): 451-6, 2006 May 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16724057
RESUMO
A cancer drug target is only truly validated by demonstrating that a given therapeutic agent is clinically effective and acts through the target against which it was designed. Nevertheless, it is desirable to declare an early-stage drug target as 'validated' before investing in a full-scale drug discovery programme dedicated to it. Although the outcome of validation studies can guide cancer research programmes, strictly defined universal validation criteria have not been established.