Quality of Life and Persistence of Symptoms in Outpatients after Recovery from COVID-19.

Background and Objectives: Patients infected with SARS-CoV-2 can have persistent symptoms after acute illness, which affects their quality of life (QoL). Research and data about this topic in Latin American ambulatory patients are scarce. Materials and Methods: We conducted an observational, prospective, transversal, and analytical study. To measure QoL, we used a validated Spanish version of the MOS/RAND 36-Item Short Form Health Survey (SF-36). Results: We included 206 outpatients in the study. A total of 73.3% patients had persistence of one or more symptoms. The most frequent persistent symptoms were fatigue (36.9%), anxiety (26.2%), and headache (24.8%). No statistically significant difference in the SF-36 QoL scores and the frequency of persistent COVID-19 symptoms was found when comparing the ≤5 and >5 months groups, except for myalgia, which was less frequently observed in the >5 months group after COVID-19 (26.2% vs. 14.1%, p < 0.038). Female gender was associated with an increased risk of persistence of symptoms (OR = 2.95, 95% CI 1.56−5.57). Having comorbidities/sequelae attributed to COVID-19 and persistence of COVID-19 symptoms were associated risk factors for poor physical component summary (PCS); on the other hand, female gender, anxiety, and depression were associated with poor mental component summary (MCS). Conclusion: Most outpatients had persistent COVID-19 symptoms after infection. Persistence of symptoms was associated with poor MCS and PCS. It is important to follow-up not only patients discharged from the hospital after SARS-CoV-2 infection, but also those under ambulatory management to provide them with rehabilitation and psychological therapy to improve their QoL.

Quality of life and persistence of COVID-19 symptoms 90 days after hospital discharge.

OBJECTIVE: We aimed to describe the persistence of symptoms in coronavirus disease 2019 (COVID-19) and quality of life (QoL) among patients 90 days after their discharge from the hospital for infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to determine differences in QoL domains concerning the absence or presence of persistent symptoms. METHODS: To measure QoL, we used a validated Spanish version of the 36-item Short Form Health Survey (SF-36). RESULTS: We included 141 patients. Ninety days after discharge, COVID-19 symptoms persisted in 107 patients (75.9%), with fatigue (55.3%) and joint pain (46.8%) being the most frequent. According to the SF-36, the role-physical score was the dimension with the lowest values (median score, 25; interquartile range, 0-75). Patients with joint pain, fatigue, and dyspnea had lower scores than patients without those symptoms, with 10 of the 13 evaluated SF-36 scales showing lower levels. CONCLUSION: Ninety days after hospital discharge from COVID-19 reference centers, most patients had persistent symptoms and had lower SF-36 scores than patients without symptoms. It is important to follow-up patients discharged from the hospital after SARS-CoV-2 infection, ideally through a post-COVID-19 health care clinic and rehabilitation program, to improve QoL in these patients.

Diagnostic Accuracy of the RDW for Predicting Death in COVID-19.

Background and Objectives: An association between high red blood cell distribution width (RDW) and mortality has been found in several diseases, including infection and sepsis. Some studies have aimed at determining the association of elevated RDW with adverse prognosis in COVID-19, but its usefulness has not been well established. The objective of this study was to determine the accuracy of the RDW, measured at hospital admission and discharge, for predicting death in patients with COVID-19. Materials andMethods: An observational, retrospective, longitudinal, and analytical study was conducted in two different COVID-19 reference centers in the state of Guanajuato, Mexico. A total of 323 patients hospitalized by COVID-19 were included. Results: We found higher RDW levels at the time of hospital admission in the non-survivors group compared to levels in survivors (median = 13.6 vs. 13.0, p < 0.001). Final RDW levels were even higher in the deceased group when compared with those of survivors (median = 14.6 [IQR, 12.67−15.6] vs. 12.9 [IQR, 12.2−13.5], p < 0.001). For patients who died, an RDW > 14.5% was more common at the time of death than for patients who survived at the time of discharge (81 vs. 13 patients, p < 0.001; RR = 2.3, 95% CI 1.89−2.81). Conclusions: The RDW is an accessible and economical parameter that, together with other characteristics of the presentation and evolution of patients with COVID-19, can be helpful in determining the prognosis. An RDW that increases during hospitalization could be a more important mortality predictor than the RDW at hospital admission.

Aminosalicilatos, tiopurínicos y metotrexato en la enfermedad inflamatoria intestinal, ¿es posible suspender el tratamiento? / Aminosalicylates, thiopurines and methotrexate in inflammatory bowel disease: Is it possible to discontinue the treatment?

Los objetivos actuales del tratamiento en la enfermedad inflamatoria intestinal (EII), tanto en enfermedad de Crohn como en colitis ulcerosa, son alcanzar la remisión clínica, endoscópica e idealmente histológica, mejorando de esta manera la calidad de vida de estos pacientes. Las terapias actuales son efectivas en lograr estos objetivos, pero no existen guías claras respecto de la duración óptima del tratamiento de mantención. Esta revisión tiene por objetivo evaluar la evidencia actual respecto del retiro de la terapia con 5-aminosalicilatos, tiopurínicos y metotrexato. A su vez, buscamos determinar grupos específicos de pacientes que, encontrándose en remisión y en ausencia de factores de riesgo, pudieran suspender la terapia con el menor riesgo de recaída posible

The current goals of treatment in inflammatory bowel disease, both Crohn's disease and ulcerative colitis, are to achieve clinical, endoscopic and ideally histological remission and improve the quality of life of these patients. Current therapies are effective in achieving remission in most cases, but there is a lack of clear guidelines on their optimal duration. This review aims to evaluate the current evidence on the withdrawal of therapy with 5-aminosalicylates, thiopurines and methotrexate. We also aim to identify which specific group of patients, while in remission and in the absence of risk factors, may be able to discontinue therapy without a significant risk of relapse

Aminosalicylates, thiopurines and methotrexate in inflammatory bowel disease: Is it possible to discontinue the treatment? / Aminosalicilatos, tiopurínicos y metotrexato en la enfermedad inflamatoria intestinal, ¿es posible suspender el tratamiento?

The current goals of treatment in inflammatory bowel disease, both Crohn's disease and ulcerative colitis, are to achieve clinical, endoscopic and ideally histological remission and improve the quality of life of these patients. Current therapies are effective in achieving remission in most cases, but there is a lack of clear guidelines on their optimal duration. This review aims to evaluate the current evidence on the withdrawal of therapy with 5-aminosalicylates, thiopurines and methotrexate. We also aim to identify which specific group of patients, while in remission and in the absence of risk factors, may be able to discontinue therapy without a significant risk of relapse.

Percutaneous endopyelotomy with electrocautery: modified techniques in the treatment of ureteropelvic junction obstruction in a child under 2 years.

OBJECTIVE: In recent years new techniques in minimally invasive treatment of congenital stenosis of ureteropelvic junction have been developed. We report the treatment of pyeloureteral stenosis in children by percutaneous endopyelotomy. METHODS: In the work up study of a child (18 months) with abdominal palpable mass, a severe left hydronephrosis with a renal pelvis diameter of 65 mm and severely thinned renal parenchyma was found. The diuretic renogram showed an obstructive pattern with impaired renal function. Initially, a retrograde dilatation balloon was placed in the ureteropelvic junction under cistoscopic control. With the patient in modified Valdivia position, percutaneous access to the renal pelvis was performed. By Seldinger technique and under fluoroscopy guide, a 5 mm laparoscopic trocar was placed in the renal pelvis. We performed a percutaneous electrical endopyelotomy of the pyeloureteral junction over the 6 mm retrograde balloon dilator passed through. We placed an antegrade double J stent that was removed at 4 weeks uneventfully. RESULT: Good results were assessed without perioperative or postoperative complications with great improvement in renal dilatation two years after the intervention. The renogram showed improvement in the pattern of the curve with a slight increase in differential renal function. CONCLUSIONS: Percutaneous endopyelotomy in children has important issues due to the lack of appropriate material. However it is possible to get good results as a minimally invasive technique. In fact, it could be the ideal technique in severe hydronephrosis with large renal pelvis that prevents the surgical or endourological approach.

Endopielotomía percutánea con electrobisturí en un lactante: modificaciones técnicas / Percutaneous endopyelotomy with electrocautery: modified techniques in the treatment of ureteropelvic junction obstruction in a child under 2 years

OBJETIVO: Las técnicas mínimamente invasivas de tratamiento de la estenosis pieloureteral desarrolladas en adultos tienen grandes dificultades para su aplicación en niños por la ausencia de material adecuado. Presentamos mejoras técnicas de la endopielotomía percutánea para su aplicación en un lactante. MÉTODO: Paciente de 18 meses con severa hidronefrosis izquierda que cruza línea media con pelvis renal de 65 mm. Se sitúa retrógradamente un balón de alta presión en unión pieloureteral tras pielografía retrógrada y paso de guía a pelvis renal. Con el paciente en posición de Valdivia modificado, se realiza el acceso percutáneo mediante técnica de Seldinger guiado por radioscopia hasta colocar un trocar de 5 mm en pelvis renal. Se realiza una endopielotomía percutánea con corte eléctrico sobre el balón. Se deja colocado un stent doble J anterógradamente que se retira a las 4 semanas. RESULTADO: Buena evolución postoperatoria sin complicaciones perioperatorias ni postoperatorias. Gran mejoría de la dilatación renal al año y dos años de la intervención. El renograma muestra clara mejoría en el patrón de la curva con leve ascenso de la función renal diferencial. CONCLUSIONES: La endopielotomía percutánea presenta dificultades en niños por la ausencia de material adecuado. Sin embargo es posible su realización con buenos resultados sin contraindicar otras técnicas posteriores. Podría ser la técnica ideal en severas hidronefrosis con grandes pelvis renales que dificultan su abordaje quirúrgico o endourológico(AU)

OBJECTIVE: In recent years new techniques in minimally invasive treatment of congenital stenosis of ureteropelvic junction have been developed. We report the treatment of pyeloureteral stenosis in children by percutaneous endopyelotomy. METHODS: In the work up study of a child (18 months) with abdominal palpable mass, a severe left hydronephrosis with a renal pelvis diameter of 65 mm and severely thinned renal parenchyma was found. The diuretic renogram showed an obstructive pattern with impaired renal function. Initially, a retrograde dilatation balloon was placed in the ureteropelvic junction under cistoscopic control. With the patient in modified Valdivia position, percutaneous access to the renal pelvis was performed. By Seldinger technique and under fluoroscopy guide, a 5 mm laparoscopic trocar was placed in the renal pelvis. We performed a percutaneous electrical endopyelotomy of the pyeloureteral junction over the 6 mm retrograde balloon dilator passed through. We placed an antegrade double J stent that was removed at 4 weeks uneventfully. RESULT: Good results were assessed without perioperative or postoperative complications with great improvement in renal dilatation two years after the intervention. The renogram showed improvement in the pattern of the curve with a slight increase in differential renal function. CONCLUSIONS: Percutaneous endopyelotomy in children has important issues due to the lack of appropriate material. However it is possible to get good results as a minimally invasive technique. In fact, it could be the ideal technique in severe hydronephrosis with large renal pelvis that prevents the surgical or endourological approach(AU)

Fístula rectouretral tras tratamiento prenatal de paciente Con valvas de uretra posterior / Rectourethral fistula after prenatal treatment of posterior urethra valves

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