RESUMO
The first 2 weeks of life in rats are known as the stress hyporesponsive period because stress responses in pups are diminished as compared to adult animals. However, it is considered a critical period in development in which infant rats are susceptible to environmental events, such as stressful stimuli and quality of maternal care received. These early life events have long-lasting effects, shaping a variety of outcomes, such as stress responsivity. This study investigated the effects of maternal care and sex differences on the response to an aversive stimulus in rat pups from high (HL) and low licking (LL) mothers. Plasma corticosterone, oxytocin (OT), and central monoaminergic activity in 13-day-old rats submitted to cold stress were analyzed. Stress increased plasma corticosterone and marginally decreased hypothalamic dihydroxyphenylacetic acid/dopamine ratio. HL pups showed higher levels of plasma OT than LL pups. The maternal effect was also detected in the hippocampus, in which 5-hydroxyindole-3-acetic acid/serotonin ratio was increased in HL pups, independently of the sex and stress. Investigating the early life events is useful not only into understand the neurobiological and hormonal mechanisms underlying maternal and stressful influences on infant development into a healthy or psychopathological adult phenotype, but also to unveil the immediate outcomes on infancy.
Assuntos
Comportamento Animal , Monoaminas Biogênicas/fisiologia , Hormônios/fisiologia , Estresse Fisiológico , Animais , Animais Recém-Nascidos , Corticosterona/sangue , Feminino , Ocitocina/sangue , Gravidez , Radioimunoensaio , Ratos , Ratos WistarRESUMO
The first 2 weeks of life in rats are known as the stress hyporesponsive period because stress responses in pups are diminished as compared to adult animals. However, it is considered a critical period in development in which infant rats are susceptible to environmental events, such as stressful stimuli and quality of maternal care received. These early life events have long-lasting effects, shaping a variety of outcomes, such as stress responsivity. This study investigated the effects of maternal care and sex differences on the response to an aversive stimulus in rat pups from high (HL) and low licking (LL) mothers. Plasma corticosterone, oxytocin, and central monoaminergic activity in 13-day-old rats submitted to cold stress were analyzed. Stress increased plasma corticosterone and marginally decreased hypothalamic dihydroxyphenylacetic acid/dopamine (DOPAC/DA) ratio. HL pups showed higher levels of plasma oxytocin than LL pups. The maternal effect was also detected in the hippocampus, in which 5-hydroxyindole-3-acetic acid/serotonin (5-HIAA/5-HT) ratio was increased in HL pups, independently of the sex and stress. Investigating the early life events is useful not only into understand the neurobiological and hormonal mechanisms underlying maternal and stressful influences on infant development into a healthy or psychopathological adult phenotype, but also to unveil the immediate outcomes on infancy.
RESUMO
Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer death among Louisiana women. The incidence data from Louisiana Tumor Registry were used to calculate breast cancer incidence rates, which were compared with the combined rates from the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) program. Breast cancer mortality rates for Louisiana were compared with the US death rates from the National Center for Health Statistics (NCHS). Our data revealed that Louisiana women were not at a higher risk for developing breast cancer than women in the SEER areas, but that mortality rates in Louisiana were not correspondingly low. Although the percentage of cases diagnosed at an early stage (in situ and localized) increased in Louisiana from 1988 through 1997, the average in Louisiana was still below the level for the SEER areas (65.9% and 71.6%) in 1993-1997. The rates of in situ breast cancer significantly increased (on average 5.3% for whites per year and 7.1% for blacks), and localized breast cancer also significantly increased (2.6% for whites and 2.5% for blacks), while the incidence of distant stage breast cancer significantly decreased (3.4% for whites and 2.0% for blacks). Compared with white women, black women still were less likely to be diagnosed with early stage breast cancer in 1993-1997 (56.4% and 68.9%). Women residing in the parishes with high percentages of persons in poverty were less likely to be diagnosed with early stage of disease.
Assuntos
Neoplasias da Mama/epidemiologia , População Negra , Neoplasias da Mama/diagnóstico , Feminino , Humanos , Incidência , Louisiana/epidemiologia , Sistema de Registros/estatística & dados numéricos , Taxa de Sobrevida , População BrancaRESUMO
OBJECTIVES: In response to a previous finding of increased mortality from lymphohaematopoietic (LH) malignancies, this study examines incidence of LH malignancy in a petrochemical industry cohort. Emphasis is on chronic lymphocytic leukaemia (CLL) and on comparisons by period of first employment. METHOD: The study cohort consists of 8942 employees who were active in the period 1970-92 and alive on 31 December 1982. Record linkage with the Louisiana tumour registry (LTR) provided information on cancer for cases occurring between 1983 and 1994. Standardised incidence ratios (SIR), with the south Louisiana population as a comparison, were computed for all cancers, all LH malignancies and specific LH subtypes. Analyses were conducted for sex and race categories, and by period of first employment, job type, duration of employment, and latency. RESULTS: 672 Cases of cancer were identified, including 59 LH malignancies. Women (n=1169) had an overall cancer SIR below unity and four LH malignancies versus 2.28 expected. Among the 7773 men, those first employed before 1950 had no overall cancer excess, a significant 1.4-fold increase in overall LH malignancies (43 observed versus 30.78 expected), and four CLL cases versus 3.27 expected. Findings for men first employed after 1950 are based on fewer cases, but there was no indication of excesses of overall cancer or LH malignancy. Numbers were too small in the group first employed after 1950 for meaningful analysis of LH malignancy subtypes such as CLL (one case). CONCLUSION: These findings do not suggest a continuing excess of CLL but do suggest a small increase in incidence of overall LH malignancy for workers first employed before 1950. This may reflect associations with earlier workplace conditions, although work related patterns are mixed. Interpretation is limited by the diverse group of diseases within LH malignancies, and the lack of control for non-work factors other than sex, age, race, and period of diagnosis. This study has a major advantage of more complete and reliable cancer ascertainment compared with the mortality investigation, and shows the feasibility and benefits of using cancer registry incidence data in an occupational cohort study.
Assuntos
Neoplasias Hematológicas/epidemiologia , Doenças Profissionais/epidemiologia , Petróleo , Adulto , Idoso , Indústria Química , Estudos de Coortes , Feminino , Seguimentos , Neoplasias Hematológicas/induzido quimicamente , Humanos , Incidência , Leucemia Linfocítica Crônica de Células B/induzido quimicamente , Leucemia Linfocítica Crônica de Células B/epidemiologia , Louisiana/epidemiologia , Masculino , Pessoa de Meia-Idade , Doenças Profissionais/induzido quimicamente , Exposição Ocupacional/efeitos adversos , Fatores de TempoRESUMO
Cancer of the colon and rectum ranks fourth for incidence and second for mortality among Louisiana residents. Incidence rates calculated from Louisiana Tumor Registry data for 1991-95 show that whites in Louisiana were diagnosed with colon cancer at approximately the same rates as those in the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program, but rates for African Americans were significantly lower in Louisiana than nationally. For rectal cancer, Louisiana incidence rates approximate the national rates for all but African-American males, whose rate was significantly lower. Mortality rates for colon and rectal cancer in Louisiana were comparable to the SEER rates, suggesting Louisiana blacks, once diagnosed, have a poorer survival than their national counterparts. Risk factors for colorectal cancer and guidelines for screening are discussed, as is an upcoming study of patient care for colon cancer.
Assuntos
População Negra , Neoplasias Colorretais/epidemiologia , Programa de SEER/estatística & dados numéricos , População Branca , Adulto , Distribuição por Idade , Idoso , Neoplasias Colorretais/mortalidade , Estudos Epidemiológicos , Feminino , Humanos , Incidência , Louisiana/epidemiologia , Masculino , Pessoa de Meia-Idade , Sistema de Registros , Fatores de Risco , Distribuição por Sexo , Estatística como Assunto , Taxa de SobrevidaRESUMO
New developments in the Louisiana Tumor Registry (LTR) over the past 3 years have enhanced the operation of the LTR and broadened its functions. Recent funding for numerous special studies and research collaborations have expanded the registry activities from data collection and special etiologic studies to more completely address the mandates of registry law, which require the LTR to participate in studies of cancer causes, treatment, and survival in order to reduce cancer morbidity and mortality in Louisiana.
Assuntos
Neoplasias/epidemiologia , Sistema de Registros , Humanos , Louisiana/epidemiologia , Avaliação de Resultados em Cuidados de Saúde/estatística & dados numéricos , Editoração/tendências , Apoio à Pesquisa como Assunto/economiaRESUMO
Because of the high density of industries along the Lower Mississippi River, there is a concern about adverse impact on health, including cancer, among residents in these parishes. This study provides an update of cancer incidence in the Industrial Corridor for the period 1989-93. Age-adjusted cancer incidence rates were calculated for the seven-parish study area from Baton Rouge down to, but not including, New Orleans. Rates were also computed for the entire state of Louisiana and for the combined Surveillance, Epidemiology and End Results (SEER) program. Cancer incidence rates for the Industrial Corridor are either similar to, or lower than, the combined SEER rates for most of the common cancers as well as for rare tumors. The only two exceptions are lung cancer in white males and kidney cancer in white females that are significantly elevated when compared to the SEER averages. Significantly lower rates are found among white males for cancers of kidney, brain, and nervous system, and melanoma; among black males, cancers of all sites combined, oral cavity, stomach, rectum, and prostate, Hodgkin's disease, and non-Hodgkin's lymphoma; among white females, cancers of all sites combined, cervix, uterine corpus, ovary, bladder, and melanoma; and among black females, cancers of all sites combined, oral cavity, lung, breast, ovary, and melanoma. The persistent excess of lung cancer has led to the development of a multi-agency project to evaluate the impact of potential environmental exposures, genetic susceptibility, and their interactions on lung cancer risk. The findings also confirm the urgent need to include and strengthen tobacco prevention and cessation programs in our cancer control activities.
Assuntos
Exposição Ambiental/efeitos adversos , Neoplasias/epidemiologia , Feminino , Humanos , Incidência , Louisiana/epidemiologia , Masculino , Neoplasias/prevenção & controle , Fatores de Risco , Programa de SEERRESUMO
This paper highlights the major findings from the recently released volume of the Louisiana Tumor Registry monograph series: Cancer Incidence in Louisiana, 1988-1992. One out of three Louisiana residents will develop cancer in his or her lifetime. Lung cancer remains the most common cancer for all races, both genders combined. Lung cancer rates for women continue to rise substantially (20% over the previous 5-year period) and African-American men in the Acadiana Region have the state's highest lung cancer rate. The number of prostate cancer cases has surpassed that of lung cancer for the first time in Louisiana men; the sizable increase since 1983 (about 50%) in prostate cancer likely reflects the recent aggressive screening by the PSA test. Breast cancer remains the most common cancer among Louisiana women and incidence rates have increased about 20% over the previous 5-year period. Geographic comparisons show that the New Orleans Region continues to have rates higher than state averages, and a clear pattern of high cancer risk has emerged for the Acadiana region. The Central Louisiana and the Baton Rouge Regions have rates lower than state averages.
Assuntos
Neoplasias/epidemiologia , Adulto , Negro ou Afro-Americano , Coleta de Dados , Feminino , Humanos , Incidência , Louisiana/epidemiologia , Masculino , Programas de Rastreamento , Neoplasias/classificação , Neoplasias/prevenção & controle , Controle de Qualidade , Sistema de Registros , Distribuição por Sexo , População BrancaRESUMO
During the period from June 1974 to June 1975, five bovine fetuses between seven to nine months old were received for necropsy from four different counties of the S. Paulo State, Brazil. All of them were from brucellosis-free herds. Necropsy revealed slight liver enlargement generally accompanied by capsular petechial hemorrhages. Enlargement and congestion of the spleen, epicardial and endocardial petechiae were present in three fetuses and one of them had lungs with some hemorrhagic lobules. Cardiac blood films of all the fetuses stained by the Pappenheim's panoptic method showed Anaplasma marginale in two to 20% of red corpuscles. When stained with acridine orange and immunofluorescent methods blood films of the first fetus specifically showed A. marginale.