Classical Hodgkin's lymphoma of the thyroid / Linfoma de Hodgkin clásico del tiroides

Hodgkin's lymphoma is characterized by the presence of Reed–Sternberg cells. The majority of cases originate at nodal sites and only rarely does it occur in extranodal locations. Here we report a case of a woman with a classical Hodgkin's lymphoma of the thyroid developed from a Hashimoto thyroiditis. She presented with a mass in her thyroid which was surgically removed. Biopsy showed a nodular sclerosis classical Hodgkin's lymphoma. Our results were similar to previously reported cases. It would appear that the lesions grew over a MALT tissue created by the lymphoid proliferation of the thyroiditis. Differential diagnosis was made between the different types of lymphomas considering those most commonly occurring in extranodal lymphoid tissues. A final diagnosis was reached after consideration of the histopathology, immunophenotyping and molecular biology (AU)

El linfoma de Hodgkin se caracteriza por la presencia de células de Reed–Sternberg. La mayor parte de los casos se originan en ganglios linfáticos y raramente en localizaciones extranodales. Comunicamos un caso de una paciente con un linfoma de Hodgkin clásico desarrollado sobre una tiroiditis de Hashimoto. Se presentó como una masa tiroidea que fue extirpada. Histológicamente mostró un linfoma de Hodgkin clásico de tipo esclerosis nodular. Nuestros resultados concuerdan con casos publicados anteriormente. La lesión posiblemente se originó sobre un tejido MALT creado por la proliferación linfoide relacionada con la tiroiditis. Realizamos diagnósticos diferenciales entre diferentes tipos de linfoma que tienen lugar en tejido linfoide extranodal. El diagnóstico final fue realizado tras considerar su histopatología, inmunofenotipo y genética molecular (AU)

Large-cell neuroendocrine carcinoma of prostate. Case report.

OBJECTIVE: To report a case of a neuroendocrine differentiation in a prostate cancer patient, a rare subtype. METHODS: We describe the case of a patient diagnosed with adenocarcinoma of the prostate initially, who presented hematuria due to disease progression with neuroendocrine differentiation despite androgen-deprivation therapy (ADT ). DISCUSSION: Prostate cancer is the most common tumor in men. Histologically they are diagnosed as adenocarcinomas, which followed by ADT for a long time, develop neuroendocrine differentiation (NED ). CONCLUSIONS: The prognostic significance of NED remains controversial. We must think in neuroendocrine differentiation in ADT-treated patient with disease progression and low PSA.

Carcinoma neuroendocrino de célula grande prostático. A propósito de un caso / Large-cell neuroendocrine carcinoma of prostate. Case report

OBJETIVO: Presentar un caso de cáncer de próstata con diferenciación neuroendocrina de célula grande, un subtipo muy infrecuente. MÉTODOS: Se describe el caso clínico de un paciente previamente diagnosticado de adenocarcinoma de próstata que debuta con hematuria como progresión de la enfermedad hacia diferenciación neuroendocrina a pesar del tratamiento hormonal. DISCUSIÓN: el cáncer de próstata es el tumor más frecuente diagnosticado en el varón. Histológicamente son diagnosticados de adenocarcinoma de próstata, que tras tratamiento hormonal durante largo tiempo desarrollan una diferenciación neuroendocrina (DNE). CONCLUSIONES: el significado pronóstico de la DNE sigue siendo controvertido. Debemos pensar en la diferenciación neuroendocrina ante un paciente en tratamiento con bloqueo hormonal, con progresión de la enfermedad, y PSA bajo (AU)

OBJECTIVE: To report a case of a neuroendocrine differentiation in a prostate cancer patient, a rare subtype. METHODS: We describe the case of a patient diagnosed with adenocarcinoma of the prostate initially, who presented hematuria due to disease progression with neuroendocrine differentiation despite androgen-deprivation therapy (ADT).DISCUSSION: Prostate cancer is the most common tumor in men. Histologically they are diagnosed as adenocarcinomas, which followed by ADT for a long time, develop neuroendocrine differentiation (NED). CONCLUSIONS: The prognostic significance of NED remains controversial. We must think in neuroendocrine differentiation in ADT-treated patient with disease progression and low PSA (AU)

Intestinal uptake of (99m)Tc-MDP: a case report of protein-losing enteropathy correlated with pathology findings from autopsy.

We present a case of a 60-year-old man with a history of severe hypoproteinemia and constitutional syndrome, suspected to have protein-losing enteropathy (PLE). Bone scintigraphy ((99m)Tc-MDP) performed to rule out the presence of bone metastases incidentally showed abnormal uptake in abdominal soft tissue. The patient unexpectedly died of heart failure, and autopsy revealed microscopic alterations consistent with PLE exclusively in the right colon, corresponding to the area of abnormal uptake. Few similar cases have been published, but none of them reported correlative pathological findings affecting the area of abnormal tracer uptake. In this case of PLE, (99m)Tc-MDP scintigraphy was a useful imaging method for localizing the site of protein loss, showing a focal area of alteration in the right colon. This finding could also have been of great help in case that surgery had been finally performed to control the protein loss.

Carcinoma suprarrenal oncocítico de bajo grado / Low grade oncocytic adrenocortical carcinoma

OBJETIVO: Presentamos un caso de un varón de 47 años con un tumor suprarrenal izquierdo heterogéneo de 16x10x7 cm., al que tras una punción-biopsia se le practicó una suprarrenalectomía por vía abdominal. MÉTODO/RESULTADOS: Estudios inmunohistoquímicos con el anticuerpo anti Melan-A A103 nos indican un origen en la corteza suprarrenal de las células tumorales. Los oncocitos son ricos en mitocondrias, y el anticuerpo antimitocondrial mES-13 nos permite ponerlas de manifiesto sin necesidad de recurrir a estudios ultraestructurales. CONCLUSIÓN: En este tipo de tumores sólo los criterios histológicos de necrosis y aumento de las mitosis permiten hacer un diagnóstico de malignidad, pero aún así su comportamiento es indolente (AU)