RESUMO
We performed threshold static perimetry on 19 patients who had ingested canthaxanthin; 11 had maculopathy and eight did not. Patients with no history of canthaxanthin ingestion served as controls. All patients had visual acuity of 6/9 or better. Threshold static perimetry was reevaluated two to three years after cessation of canthaxanthin ingestion. For both testing sessions, patients with maculopathy presented lower retinal sensitivity than controls, while patients without maculopathy did not differ significantly from the control group. These results suggest that canthaxanthin retinopathy can adversely affect the neurosensory retina.
Assuntos
Carotenoides/análogos & derivados , Macula Lutea , Doenças Retinianas/induzido quimicamente , Testes de Campo Visual , Adulto , Cantaxantina , Carotenoides/efeitos adversos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Retina/patologia , Doenças Retinianas/patologia , Doenças Retinianas/fisiopatologia , Limiar Sensorial , Visão OcularRESUMO
A retrospective study of 14 cases of retinopathy due to canthaxanthine, a carotenoid recently used as a skin-tanning agent, revealed that several clinical factors were associated with an increased susceptibility to retinal deposits: focal epitheliopathy, ocular hypertension and, possibly, the concurrent use of beta-carotene. Age has already been established as such a factor.
Assuntos
Carotenoides/análogos & derivados , Doenças Retinianas/induzido quimicamente , Adulto , Idoso , Cantaxantina , Carotenoides/efeitos adversos , Interações Medicamentosas , Feminino , Angiofluoresceinografia , Humanos , Masculino , Pessoa de Meia-Idade , Hipertensão Ocular/complicações , Doenças Retinianas/diagnóstico , Estudos Retrospectivos , Dermatopatias/complicações , beta CarotenoRESUMO
Canthaxanthine, a non-provitamin A carotenoid, has been marketed in Canada since March 1979 as a skin-tanning agent. Fifty-one individuals who ingested from 3.6 to 66 g of the drug within a 24-month period were ophthalmologically evaluated. Six of them had deposits in the ocular fundus that appeared to be related to ingestion of the substance, but no functional impairment could be detected.
Assuntos
Carotenoides/análogos & derivados , Doenças Retinianas/induzido quimicamente , Administração Oral , Adulto , Cantaxantina , Carotenoides/efeitos adversos , Carotenoides/farmacologia , Esquema de Medicação , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Retinianas/patologia , Pele/efeitos dos fármacosRESUMO
This article describes two patients with a bilateral maculopathy due to the presence of numerous glistening yellow particles located mainly around the edge of the macular pit. This picture has apparently not been reported before. Further studies are needed to confirm a possibly toxic origin.
Assuntos
Edema/diagnóstico , Macula Lutea/patologia , Doenças Retinianas/diagnóstico , Adulto , Idoso , Cantaxantina , Carotenoides/efeitos adversos , Carotenoides/análogos & derivados , Síndrome do Túnel Carpal/complicações , Feminino , Angiofluoresceinografia , Humanos , Artropatias/complicações , Masculino , Pigmentos Biológicos , Doenças Retinianas/induzido quimicamente , Doenças Retinianas/patologiaAssuntos
Eletrorretinografia , Adulto , Eletrodiagnóstico , Eletrônica Médica , Eletrofisiologia , Feminino , Humanos , Masculino , Retina/fisiologiaRESUMO
In a group of 15 males with X-linked ocular albinism and 13 obligate carriers of the gene for the condition skin biopsy in a search for giant pigment granules with light microscopy and macromelanosomes with electron microscopy gave positive results more often than iris transillumination and funduscopy. Thus, skin biopsy should significantly improve the detection of both affected males and carriers.
Assuntos
Albinismo/genética , Fundo de Olho , Triagem de Portadores Genéticos , Iris , Cromossomos Sexuais , Cromossomo X , Albinismo/diagnóstico , Biópsia , Feminino , Ligação Genética , Humanos , Masculino , Melanócitos/ultraestrutura , Microscopia Eletrônica , Fatores Sexuais , Pele/patologia , TransiluminaçãoRESUMO
Three middle-aged male patients are described with a peculiar patterned dystrophy of the macula. The basic lesions are discrete yellow plaques typically confined to the macular area and radiating from the fovea. They appear to be located at the level of the retinal pigment epithelium (RPE). With the passage of time some of the yellow plaques altered in extent and configuration, and atrophic changes appeared or extended. Visual acuity and electrophysiological tests are either normal or only moderately affected. The lesions appear to be distinct from the patterned dystrophies of the retina already described and from other conditions characterised by yellow or white deposits at the level of the RPE.