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J Pediatr ; 159(1): 21-26.e1, 2011 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-21324477

RESUMO

OBJECTIVES: To determine the relationship between single nucleotide polymorphisms in candidate genes associated with multiple asthma phenotypes and health-related quality of life (HRQOL). STUDY DESIGN: A cross-sectional study was conducted at a pediatric hospital in 275 school-aged children diagnosed with asthma and their caregivers. Genomic DNA was obtained from children, and caregivers completed a measure of their child's HRQOL. Analysis of variance was used to investigate the association between single nucleotide polymorphisms and HRQOL. RESULTS: Children homozygous for the major variant at IL-4RA rs 1805010 had significantly better HRQOL than their counterparts. Significant associations with pulmonary function were not observed. CONCLUSIONS: Genes associated with asthma phenotype can be associated with HRQOL at least partly independent of pulmonary function.


Assuntos
Asma/genética , Polimorfismo de Nucleotídeo Único , Qualidade de Vida , Análise de Variância , Criança , Estudos Transversais , Feminino , Marcadores Genéticos , Genótipo , Glutationa S-Transferase pi/genética , Homozigoto , Hospitais Pediátricos , Humanos , Interleucina-13/genética , Interleucina-4/genética , Receptores de Lipopolissacarídeos/genética , Masculino , Receptores de Interleucina-4/genética , Inquéritos e Questionários
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