1.
Bioorg Med Chem Lett
; 24(4): 1122-6, 2014 Feb 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24440302
RESUMO
Aminoglycoside-antibiotics represent important tools for studying the biological functions of RNA. An orthogonal protection strategy applied on 2-deoxystreptamine (2-DOS) revealed a series of key intermediates that enable its regioselective functionalization. Our approach allowed the construction of selected representatives of triazole-containing analogues with diverse molecular frameworks for biological evaluation regarding their binding and antibacterial potencies.