RESUMO
ABSTRACT Oral lymphoepithelial cyst (OLEC) is an uncommon lesion whose pathogenesis remains poorly understood. The purpose of this paper is to report a case of OLEC. Female patient, white, 62 years old, presented asymptomatic nodular swelling of soft consistency in the lateral border of the tongue. Under the clinical hypothesis of lymphoid tissue hyperplasia, an excisional biopsy was performed. Histopathological examination revealed a pathological epithelial-lined cavity and a cystic connective tissue capsule containing lymphoid tissue. The diagnosis of OLEC was established and the patient showed no signs of recurrence after surgical removal of the lesion.
RESUMEN El quiste linfoepitelial (QLE) oral es una lesión infrecuente, cuya patogénesis es aún poco conocida. El objetivo del presente estudio es reportar un caso de QLE oral. Mujer blanca de 62 años presentó un crecimiento nodular asintomático de consistencia blanda, en borde lateral de la lengua. Bajo la hipótesis clínica de hiperplasia del tejido linfoide, se realizó una biopsia excisional. El examen histopatológico reveló cavidad patológica revestida de epitelio y una cápsula quística de tejido conectivo, conteniendo tejido linfoide. Se estableció el diagnóstico de QLE oral. La paciente no ha presentado recidiva tras extirpación quirúrgica de la lesión.
RESUMO O cisto linfoepitelial oral (CLEO) é uma lesão incomum, cuja patogênese ainda é pouco elucidada. O objetivo deste estudo é relatar um caso de CLEO. Paciente do sexo feminino, leucoderma, 62 anos, apresentou aumento de volume nodular assintomático de consistência amolecida, em borda lateral da língua. Sob a hipótese clínica de hiperplasia de tecido linfoide, biópsia excisional foi realizada. O exame histopatológico revelou cavidade patológica revestida por epitélio e uma cápsula cística de tecido conjuntivo, contendo tecido linfoide. O diagnóstico de CLEO foi estabelecido. A paciente não apresentou sinais de recidiva após a remoção cirúrgica da lesão.
RESUMO
PURPOSE: In the present study, we investigated the presence of human papillomavirus (HPV) DNA and viral types in 75 cases of oral squamous cells carcinoma from Brazil to obtain data that would contribute to a better understanding of the role of HPV in the pathogenesis of this tumor. MATERIALS AND METHODS: DNA was extracted from paraffin-embedded tissue and amplified by polymerase chain reaction using a pair of primers designated PCO3+ and PCO4+ for the detection of a fragment of the human beta-globin gene, followed by polymerase chain reaction for the detection of HPV DNA using a pair of generic primers, GP5+ and GP6+. Viral typing was performed by dot blot hybridization. RESULTS: Human papillomavirus DNA was detected in 18 (24%) of the 75 cases positive for the human beta-globin gene. No significant association was observed between HPV and age, sex, or anatomical location of the tumor. The most prevalent viral type was HPV-18 (77,8%). CONCLUSION: The low frequency of detection of HPV DNA in oral epidermoid carcinomas suggests a possible participation of the virus in the development and progression of only a subgroup of these tumors.
Assuntos
Alphapapillomavirus/isolamento & purificação , Carcinoma de Células Escamosas/virologia , DNA Viral , Neoplasias Bucais/virologia , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Brasil , Carcinoma de Células Escamosas/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/patologia , Reação em Cadeia da Polimerase , Fatores SexuaisRESUMO
An immunohistochemical analysis of 32 cases of oral squamous cell carcinoma (eight in the inferior lip, eight in the lateral angle of the tongue, eight in the palate and eight in the mouth floor) was performed to evaluate the expression pattern of c-erbB-2 protein and S-100-positive cells in the lesions. The immunohistochemical expression was correlated with the tumour anatomical site and histological grading of malignancy. A higher frequency of c-erbB-2-positive cases was found in the tongue, even though no correlation could be detected between the protein expression and the tumour histological grading. With respect to the S-100-positive cells, it was observed that a quantitative decrease was present in the cases classified as high-grade tumours when compared to the low ones (P = 0.0007). Thus, c-erbB-2 immunohistochemical expression is correlated with anatomical localization, and the expression of the S-100 Langerhans' cell markers is decreased significantly in high-grade carcinomas.