Treadmill Exercise Reverses the Adverse Effects of Intermittent Fasting on Behavior and Cortical Spreading Depression in Young Rats.

Intermittent fasting (IF) and physical exercise (PE) have beneficial psychological and physiological effects, improving memory and anxiety-like behavior. However, the impact of this combination on brain electrophysiological patterns is unknown. We aimed to evaluate the behavior and parameters of a brain excitability-related phenomenon named cortical spreading depression (CSD) in young rats (31-87 days of life) submitted to IF and treadmill PE for eight weeks. Sixty-four male and female Wistar rats aged 24 days were randomized into control, IF, PE, and IF+PE groups. Behavioral tests (open field (OF), object recognition, and elevated plus maze (EPM)) were performed, and the CSD propagation features were recorded. IF caused behavioral responses indicative of anxiety (lower number of entries and time spent in the OF center and EPM open arms). IF also reduced the discrimination index for object recognition memory tests and increased the propagation velocity of CSD. PE rats displayed more entries into the OF center and lowered CSD propagation speed. Data suggest that IF worsens anxiety-like behavior and memory and accelerates CSD in young rats. In contrast, PE reverted the unfavorable effects of IF. The brain effects of IF and PE at younger ages are recommended for study.

Aneurisma da artéria isquiática persistente: relato de caso de tratamento endovascular / Persistent sciatic artery aneurysm: case report of endovascular treatment

A persistência da artéria isquiática é uma anomalia vascular congênita rara cuja principal complicação é a dilatação aneurismática. O quadro clínico pode incluir sintomas decorrentes da dilatação arterial e da isquemia, causada por trombose ou embolização distal. O tratamento dessa afecção rara conta com opções diversas que abrangem desde a ligadura do aneurisma até a correção endovascular. O presente relato descreve o caso de uma paciente do sexo feminino com queixa de tumoração pulsátil na região glútea. Foi encaminhada ao serviço de referência e realizou angiotomografia, que evidenciou persistência completa da artéria isquiática bilateralmente, com dilatação aneurismática à esquerda. A paciente foi submetida a tratamento endovascular do aneurisma, através de punção contralateral, com implante de dois stents revestidos com manutenção da perviedade distal da artéria. A manutenção da perviedade é particularmente importante nos casos da forma completa dessa variação anatômica. A paciente cursou com boa evolução

A persistent sciatic artery is a rare congenital vascular anomaly. The most common complication is aneurysm. Clinical presentation may include symptoms resulting from arterial dilatation and ischemia caused by thrombosis or embolization. There are diverse options for treatment of this rare condition, ranging from ligature of the aneurism to endovascular repair. This report describes the case of a female patient complaining of a pulsating mass in the left buttock. She was referred to a Vascular Service where an angiotomography showed complete bilateral persistence of the sciatic artery, with an aneurysm of the left sciatic artery. The aneurysm was treated with endovascular techniques, via a contralateral approach, with placement of two stent grafts and preservation of distal patency. Patency is particularly important in cases of this anatomical variation in which the persistent sciatic artery is complete. This patient recovered well