In vivo characterization of a versatile 8-channel digital biopotential recording system with sub-µVRMS input noise.

This work presents the design and testing of an integrated 8-channel CMOS biopotential recording chip, consisting of low-noise input stages, tunable second stage, a multiplexer, and two analog-to-digital converters (ADC). Through its variable supply concept, the integrated input-referred noise of the first stage is selectable from 1.5 down to 0.63 µVRMS (ISS = 200 µA), which is superior to standard laboratory recording systems. The device features variable lower and upper corner frequencies, and outputs two digital 16-bit data streams at 62.5 kS/s. The chip die was fabricated in X-Fab 0.35 µm CMOS technology and has an area of 10 mm2.