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1.
Proc Math Phys Eng Sci ; 477(2248): 20200874, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35153554

RESUMO

The freezing phenomena in supercooled liquid droplets are important for many engineering applications. For instance, a theoretical model of this phenomenon can offer insights for tailoring surface coatings and for achieving icephobicity to reduce ice adhesion and accretion. In this work, a mathematical model and hybrid numerical-analytical solutions are developed for the freezing of a supercooled droplet immersed in a cold air stream, subjected to the three main transport phenomena at the interface between the droplet and the surroundings: convective heat transfer, convective mass transfer and thermal radiation. Error-controlled hybrid solutions are obtained through the extension of the generalized integral transform technique to the transient partial differential formulation of this moving boundary heat transfer problem. The nonlinear boundary condition for the interface temperature is directly accounted for by the choice of a nonlinear eigenfunction expansion base. Also, the nonlinear equation of motion for the freezing front is solved together with the ordinary differential system for the integral transformed temperatures. After comparisons of the solution with previously reported numerical and experimental results, the influence of the related physical parameters on the droplet temperatures and freezing time is critically analysed.

2.
Biology (Basel) ; 9(8)2020 Aug 12.
Artigo em Inglês | MEDLINE | ID: mdl-32806613

RESUMO

A SIRU-type epidemic model is employed for the prediction of the COVID-19 epidemy evolution in Brazil, and analyze the influence of public health measures on simulating the control of this infectious disease. The proposed model allows for a time variable functional form of both the transmission rate and the fraction of asymptomatic infectious individuals that become reported symptomatic individuals, to reflect public health interventions, towards the epidemy control. An exponential analytical behavior for the accumulated reported cases evolution is assumed at the onset of the epidemy, for explicitly estimating initial conditions, while a Bayesian inference approach is adopted for the estimation of parameters by employing the direct problem model with the data from the first phase of the epidemy evolution, represented by the time series for the reported cases of infected individuals. The evolution of the COVID-19 epidemy in China is considered for validation purposes, by taking the first part of the dataset of accumulated reported infectious individuals to estimate the related parameters, and retaining the rest of the evolution data for direct comparison with the predicted results. Then, the available data on reported cases in Brazil from 15 February until 29 March, is used for estimating parameters and then predicting the first phase of the epidemy evolution from these initial conditions. The data for the reported cases in Brazil from 30 March until 23 April are reserved for validation of the model. Then, public health interventions are simulated, aimed at evaluating the effects on the disease spreading, by acting on both the transmission rate and the fraction of the total number of the symptomatic infectious individuals, considering time variable exponential behaviors for these two parameters. This first constructed model provides fairly accurate predictions up to day 65 below 5% relative deviation, when the data starts detaching from the theoretical curve. From the simulated public health intervention measures through five different scenarios, it was observed that a combination of careful control of the social distancing relaxation and improved sanitary habits, together with more intensive testing for isolation of symptomatic cases, is essential to achieve the overall control of the disease and avoid a second more strict social distancing intervention. Finally, the full dataset available by the completion of the present work is employed in redefining the model to yield updated epidemy evolution estimates.

3.
An Acad Bras Cienc ; 92(1): e20190427, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32267291

RESUMO

The Generalized Integral Transform Technique (GITT) was employed to simulate transient one-dimensional flow in variably saturated porous media, as well as radioactive waste transport within different layers (a solid waste pile, nearby soil, and a granular aquifer) towards the edge of a uranium mining installation under institutional control. Computational codes, written using the Mathematica software system, were implemented and tested for solution of the coupled advection-dispersion equations for an arbitrary number of daughter products within a radioactive chain migrating in saturated and unsaturated soil layers. The computer simulations were verified in great detail against results obtained using the built-in routine NDSolve of the Mathematica platform and the HYDRUS-1D software system. The present work reports the main results for 238U chain radionuclide transport using data extracted from a safety assessment of solid waste repositories at a uranium mining and milling installation in Caetité, state of Bahia, Brazil, operated by INB (Indústrias Nucleares do Brasil). Concentration evolutions of the various radionuclides obtained with the simulations were analyzed for five different cases to explore variations in the infiltration and recharge rates, the effect of assuming physical equilibrium or non-equilibrium transport conditions, and of different initial concentrations of some of the radionuclides.

4.
An Acad Bras Cienc ; 87(3): 1865-85, 2015 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26312419

RESUMO

This paper aims to renew interest on mixed thermal convection research and to emphasize three issues that arise from the present analysis: (i) a clear definition of the reference temperature in the Boussinesq approximation; (ii) a practical delimitation of the three convective modes, which are the forced convection (FC), mixed convection (MC) and natural (or free) convection (NC); (iii) and, finally, a uniform description of the set FC/MC/NC in the similarity framework. The planar case, for which analytical solutions are available, allows a detailed illustration of the answers here advanced to the above issues.

5.
J Comput Biol ; 22(7): 649-65, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-25973723

RESUMO

Cancer is characterized by the uncontrolled growth of cells with the ability of invading local organs and/or tissues and of spreading to other sites. Several kinds of mathematical models have been proposed in the literature, involving different levels of refinement, for the evolution of tumors and their interactions with chemotherapy drugs. In this article, we present the solution of a state estimation problem for tumor size evolution. A system of nonlinear ordinary differential equations is used as the state evolution model, which involves as state variables the numbers of tumor, normal and angiogenic cells, as well as the masses of the chemotherapy and anti-angiogenic drugs in the body. Measurements of the numbers of tumor and normal cells are considered available for the inverse analysis. Parameters appearing in the formulation of the state evolution model are treated as Gaussian random variables and their uncertainties are taken into account in the estimation of the state variables, by using an algorithm based on the auxiliary sampling importance resampling particle filter. Test cases are examined in the article dealing with a chemotherapy protocol for pancreatic cancer.


Assuntos
Neoplasias/patologia , Algoritmos , Antimetabólitos Antineoplásicos/farmacocinética , Simulação por Computador , Desoxicitidina/análogos & derivados , Desoxicitidina/farmacocinética , Diagnóstico por Computador , Meia-Vida , Humanos , Modelos Biológicos , Método de Monte Carlo , Neoplasias/tratamento farmacológico , Carga Tumoral , Gencitabina
6.
Braz. arch. biol. technol ; 49(spe): 31-40, Jan. 2006. ilus, tab, graf
Artigo em Inglês | LILACS | ID: lil-424195

RESUMO

The flash method, proposed by Parker, Butler, Jenkins and Abbott from the U.S. Navy Radiological Defense Laboratory in 1961, is the most popular method for measuring the thermal diffusivity of solids. In this method, the front surface of a small sample is subjected to a very short burst of radiant thermal energy. The resulting temperature rise on the opposite surface of the sample is measured and the thermal diffusivity is computed from the temperature rise versus time data. Also, the specific heat can be computed from the measured data, thus allowing for the calculation of the thermal conductivity. Several theoretical models are available for the flash method, which include adiabatic boundary conditions, heat losses, surface coating effects, among other aspects. In this paper, tests were made for the identification of thermo-physical properties of a Ceramic block. The Netzsch Nanoflash LFA 447/1 of LTTC/COPPE/UFRJ was used for the measurements.

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