RESUMO
BACKGROUND AND AIMS: Airway evaluation following infant cardiac surgery often reveals evidence of tracheobronchial narrowing. We studied the association between airway narrowing and extubation failure (EF) in this population. METHODS: Prospective cohort study of infants (age ≤6 months) from March-September 2009. Flexible bronchoscopy (FB) evaluations were obtained using a standardised protocol after operative intervention. The primary endpoint was the development of extubation failure (EF; defined as the need for invasive mechanical ventilation ≤48 h after primary extubation) and several secondary endpoints. RESULTS: Fifty-three patients were evaluated at a median age of 81 [interquartile range (IQR) 13-164] days and weight of 4.2 (IQR 3.2-6.0) kg; 13 (25 %) of the patients had single ventricle palliations and two subsequently underwent heart transplantation. Significant airway narrowing was noted in 15 of 30 [50 %, 95 % confidence interval (CI) 31-69 %] patients who underwent FB; ten of the 53 patients (19 %, 95 %CI 10-32 %) subsequently developed EF. Narrowed airway calibre on bronchoscopy had a sensitivity and specificity of 50 % (95 %CI 28-71 %) and 50 % (95 %CI 28-71 %), respectively, for EF. The single greatest predictor of EF by univariate analysis was the need for preoperative ventilation [odds ratio (OR) 6.5, 95 %CI 1.3-33.2, p = 0.03]. Patients with EF had a greater likelihood of intensive care readmission (OR 4.8, 95 %CI 1.1-21, p < 0.04) during the same hospital admission. CONCLUSIONS: Airway narrowing on FB is noted frequently after infant cardiac surgery. Overall assessment and presence of narrowing on bronchoscopy had poor sensitivity and specificity for EF in our cohort. Expert assessment of tracheobronchial narrowing on FB has poor to moderate inter-rater reliability.
Assuntos
Extubação , Obstrução das Vias Respiratórias/diagnóstico , Broncoscopia , Cardiopatias Congênitas/cirurgia , Complicações Pós-Operatórias/diagnóstico , Constrição Patológica , Cardiopatias Congênitas/terapia , Humanos , Lactente , Recém-Nascido , Valor Preditivo dos Testes , Estudos Prospectivos , Sensibilidade e EspecificidadeRESUMO
BACKGROUND: After institutional approval and parental consent, 103 children, aged 6 months to 18 years, who were undergoing repair of simple and complex congenital heart lesions using cardiopulmonary bypass (CPB) were studied and compared with a group of 135 children who had undergone similar surgery in our institution in the year before. METHODS: Anaesthesia for study patients included fentanyl (< 20 microg.kg-1) and isoflurane. Infusions of propofol (median infusion rate 70 microg.kg-1.min-1) and morphine (median infusion rate 20 microg.kg-1.h-1) were started after weaning from CPB and continued postoperatively. Preestablished criteria were used in the intensive care unit (ICU) to assess readiness for tracheal extubation. RESULTS: Median time from admission to ICU to tracheal extubation was 5 h. Fifty-six children were extubated within 6 h and 73 within 9 h of ICU admission. Mean ICU stay for study patients was 1.7 days [95% confidence interval (CI) 1.2-2.2] and 2.6 days (95% CI 2.3-2.9) in the comparison group (P<0.005). CONCLUSIONS: We found the propofol regimen to be satisfactory with a shorted ICU stay for these patients.
Assuntos
Analgésicos Opioides , Anestésicos Combinados , Cardiopatias Congênitas/cirurgia , Hipnóticos e Sedativos , Intubação Intratraqueal , Propofol , Adolescente , Anestésicos Inalatórios , Anestésicos Intravenosos , Criança , Pré-Escolar , Fentanila , Humanos , Lactente , Unidades de Terapia Intensiva Pediátrica , Isoflurano , MorfinaRESUMO
OBJECTIVE: To determine whether using a small tidal volume (5 ml/kg) ventilation following sustained inflation with positive endexpiratory pressure (PEEP) set above the critical closing pressure (CCP) allows oxygenation equally well and induces as little lung damage as high-frequency oscillation following sustained inflation with a continuous distending pressure (CDP) slightly above the CCP of the lung. MATERIAL AND METHODS: Twelve surfactant-depleted adult New Zealand rabbits were ventilated for 4 h after being randomly assigned to one of two groups: group 1, conventional mechanical ventilation, tidal volume 5 ml/kg, sustained inflation followed by PEEP > CCP; group 2, high-frequency oscillation, sustained inflation followed by CDP > CCP. RESULTS: In both groups oxygenation improved substantially after sustained inflation (P < 0.05) and remained stable over 4 h of ventilation without any differences between the groups. Histologically, both groups showed only little airway injury to bronchioles, alveolar ducts, and alveolar airspace, with no difference between the two groups. Myeloperoxidase content in homogenized lung tissue, as a marker of leukocyte infiltration, was equivalent in the two groups. CONCLUSIONS: We conclude that a volume recruitment strategy during small tidal volume ventilation and maintaining lung volumes above lung closing is as protective as that of high-frequency oscillation at similar lung volumes in this model of lung injury
Assuntos
Ventilação de Alta Frequência/métodos , Ventilação com Pressão Positiva Intermitente/métodos , Síndrome do Desconforto Respiratório/prevenção & controle , Mecânica Respiratória , Animais , Ventilação de Alta Frequência/efeitos adversos , Ventilação com Pressão Positiva Intermitente/efeitos adversos , Pulmão/patologia , Peroxidase/metabolismo , Troca Gasosa Pulmonar , Coelhos , Distribuição Aleatória , Síndrome do Desconforto Respiratório/fisiopatologia , Volume de Ventilação PulmonarRESUMO
OBJECTIVE: Partial liquid ventilation (PLV) improves gas exchange in animal studies of lung injury. Perfluorocarbons (PFCs) are heavy liquids and are therefore preferentially delivered to the most dependent areas of lung. We hypothesised that improved oxygenation during PLV might be the consequence of a redistribution of pulmonary blood flow away from poorly ventilated, dependent alveoli, leading to improved ventilation/perfusion (V/Q) matching. This study investigated whether partially filling the lung with PFC would result in a redistribution of pulmonary blood flow. DESIGN: Prospective experimental study. SETTING: Hospital research institute laboratory. PARTICIPANTS: Six anaesthetised pigs without lung injury. INTERVENTIONS: Animals were anaesthetised and ventilated (gas tidal volume 12 ml/kg, PEEP 5, FIO2 1.0, rate 16). Whilst the pigs were maintained in the supine position, regional pulmonary blood flow was measured during conventional gas ventilation and repeated during PLV. Flow to regions of lung was determined by injection of radioactive microspheres (Co(57), Sn(113), Sc(46)). Measurements were performed with ventilation held at end-expiratory pressure and, in two PLV animals only, repeated with ventilation held at peak inspiratory pressure. RESULTS: During conventional gas ventilation, blood flow followed a linear distribution with the highest flow to the most dependent lung. In the lung partially filled with PFC a diversion of blood flow away from the most dependent lung was seen (p = 0.007), resulting in a more uniform distribution of flow down the lung (p = 0.006). Linear regression analysis (r2 = 0.75) also confirmed a difference in distribution pattern. On applying an inspiratory hold to the liquid-containing lung, blood flow was redistributed back towards the dependent lung. CONCLUSIONS: Partially filling the lung with PFC results in a redistribution of pulmonary blood flow away from the dependent region of the lung. During PLV a different blood flow distribution may be seen between inspiration and expiration. The clinical significance of these findings has yet to be determined.
Assuntos
Fluorocarbonos/administração & dosagem , Ventilação Líquida/métodos , Circulação Pulmonar , Síndrome do Desconforto Respiratório/terapia , Animais , Pressão Sanguínea , Débito Cardíaco , Hemodinâmica , Modelos Lineares , Artéria Pulmonar , Suínos , Resistência VascularRESUMO
OBJECTIVES: Children waiting for organ transplants continue to die because of the shortage of available organs. Studies of organ donation in children are scarce. The evaluation of the organ donation experience in a pediatric tertiary care hospital may identify factors that influence actual organ donation rates and lead to strategies to improve pediatric organ donation. DESIGN: Retrospective study. SETTING: Pediatric intensive care unit in a Canadian pediatric referral center. PATIENTS: All children with brain death over an 8-yr period (1990-1997). INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Of 199 children who fulfilled the criteria for brain death, 153 were medically suitable for organ donation. Families were approached for consent to organ donation in 128 (84%) of the 153 suitable cases. Consent was obtained in 63% (81/128) of those asked. Brain death caused by acute neurosurgical lesions was highly correlated to medical suitability and consent. Families identified as ethnic minorities were significantly more likely to refuse. After consent was granted, organs were procured from 63 (78%) of 81 donors, for an average of 3.6 organs transplanted per donor. There was a failure to procure organs in 22% (18/81) of cases after consent had been granted, primarily as a result of cardiocirculatory instability while in the intensive care unit. CONCLUSIONS: Despite an encouraging 63% consent rate for organ donation when families are approached, only 41% of potential donors proceeded to actual donation. Strategies for a prospective pediatric study should focus on mandatory request, multicultural issues, and aggressive postconsent medical management and procurement. The pivotal role of the pediatric intensive care unit practitioner should be emphasized.
RESUMO
The article describes the evolution of high frequency oscillation since its first use by Lunkenheimer through the initial failed NIH trial and subsequent more successful trials to its current widespread use in the neonatal population. The importance of oscillating at an optimal lung volume, achieved through a volume recruitment manoeuvre, is emphasised as is the efficacy with which oscillation clears CO2. The lack of adequate control of these two factors in the initial NIH trial is suggested as a possible cause of the trial's failure. Comment is made on optimising oscillator settings as well on elementary mechanics of high frequency oscillation and the effect of high frequency oscillation on surfactant degradation. Given the difficulty of recruiting lung volume in late RDS, a suggestion is made to combine high frequency oscillation with perfluorocarbon. The former as a mechanism for maintaining lung volume which has been recruited by the perfluorocarbon. The authors speculate that the use of high frequency oscillation will increase in both the paediatric and adult population.
Assuntos
Ventilação de Alta Frequência , Síndrome do Desconforto Respiratório do Recém-Nascido/terapia , Síndrome do Desconforto Respiratório/terapia , Adulto , Criança , Ensaios Clínicos como Assunto , Humanos , Recém-Nascido , Medidas de Volume PulmonarRESUMO
OBJECTIVES: Ventilation with positive end-expiratory pressure (PEEP) above the inflection point (P(inf)) has been shown to reduce lung injury by recruiting previously closed alveolar regions; however, it carries the risk of hyperinflating the lungs. The present study examined the hypothesis that a new strategy of recruiting the lung with a sustained inflation (SI), followed by ventilation with small tidal volumes, would allow the maintenance of low PEEP levels (
P(inf). MEASUREMENTS AND MAIN RESULTS: In groups 2 and 4, static compliance decreased after ventilation (p < .01). Histologically, group 2 (PEEP < P(inf) without SI) showed significantly greater injury of small airways, but not of terminal respiratory units, compared with group 1. Group 3 (PEEP < P(inf) after a SI), but not group 4, showed significantly less injury of small airways and terminal respiratory units compared with group 2. CONCLUSIONS: We conclude that small tidal volume ventilation after a recruitment maneuver allows ventilation on the deflation limb of the pressure/volume curve of the lungs at a PEEP < P(inf). This strategy a) minimizes lung injury as well as, or better than, use of PEEP > P(inf), and b) ensures a lower PEEP, which may minimize the detrimental consequences of high lung volume ventilation.
Assuntos
Ventilação com Pressão Positiva Intermitente/métodos , Síndrome do Desconforto Respiratório/terapia , Mecânica Respiratória , Análise de Variância , Animais , Insuflação , Complacência Pulmonar , Respiração com Pressão Positiva , Estudos Prospectivos , Distribuição Aleatória , Ratos , Ratos Sprague-Dawley , Síndrome do Desconforto Respiratório/patologia , Capacidade Pulmonar TotalRESUMO
OBJECTIVES: To test the hypotheses that during small tidal volume ventilation (5 mL/kg) deliberate volume recruitment maneuvers allow expansion of atelectatic lung units and that a high positive end-expiratory pressure (PEEP) above the lower inflection point of the pressure/volume (PV) curve is not necessarily required to maintain recruited lung volume in acute lung injury. DESIGN: Prospective, randomized, controlled animal study. SETTING: An animal laboratory in a university setting. SUBJECTS: Adult New-Zealand rabbits. INTERVENTIONS: We studied a) the relationship of dynamic loops during intermittent positive pressure ventilation to the quasi-static PV curve, and b) the effect of lung recruitment on oxygenation, end-expiratory lung volume (EELV), and dynamic compliance in two groups (n = 4 per group) of lung-injured animals (lung lavage model): 1) the sustained inflation group, which received ventilation after a recruitment maneuver (sustained inflation); and 2) the control group, which received ventilation without any lung recruitment. MEASUREMENTS AND MAIN RESULTS: In the presence of PV hysteresis, a single sustained inflation to 30 cm H2O boosted the ventilatory cycle onto the deflation limb of the PV curve. This resulted in a significant increase in EELV, oxygenation, and dynamic compliance despite equal PEEP levels used before and after the recruitment maneuver. Furthermore, after a single sustained inflation, oxygenation remained high over 4 hrs of ventilation when a PEEP above the critical closing pressure of the lungs, defined as "optimal" PEEP, was used and was significantly higher compared with that in the control group ventilated at equal PEEP without preceding lung recruitment. CONCLUSIONS: The observation that ventilation occurs on the deflation limb of the tidal cycle-specific PV curve allows placement of the ventilatory cycle, by means of a recruitment maneuver, onto the deflation limb of the PV envelope of the optimally recruited lung. This strategy ensures sufficient lung volume recruitment to maintain the lungs during the tidal cycle while using relatively low airway pressures.
Assuntos
Ventilação com Pressão Positiva Intermitente/métodos , Síndrome do Desconforto Respiratório/terapia , Mecânica Respiratória , Análise de Variância , Animais , Insuflação , Complacência Pulmonar , Respiração com Pressão Positiva , Estudos Prospectivos , Coelhos , Distribuição Aleatória , Estatísticas não Paramétricas , Capacidade Pulmonar TotalRESUMO
OBJECTIVE: To evaluate whether changes have occurred at our center in the rate of nosocomial infections and in the infectious organisms consequent to changes in policy and procedure as of 1987. SETTING: Multidisciplinary pediatric intensive care unit (PICU) in a major tertiary care center. DESIGN: Prospective comparative study. PATIENTS: Four-hundred and fifty-five consecutive patients who underwent cardiac surgery within a 10-month period. INTERVENTIONS: Changes related to antibiotic use and invasive device management were introduced after the 1987 survey. To determine the effect of these changes, all patients undergoing cardiac surgery between July 1991 and April 1992 were followed daily from PICU admission to 2 months after hospital discharge for signs of infection. Each infectious episode was reviewed by the nosocomial infection control committee. A weighted scoring system was used to determine risk. MEASUREMENTS AND MAIN RESULTS: In the 1987 study, 40 of 310 patients had 78 infections for a nosocomial infection ratio (NIR) of 25.2. Of the 455 patients surveyed in 1992, 72 had 91 episodes of infection. The nosocomially infected patient rate was 15.8 and the NIR was 20. The frequency of wound infection decreased from 7% in 1987 to 4.3% in this study, and no episode of mediastinitis was observed. In the bacteriological spectrum, the absence of candidal infection was significant, and there was a decrease in the proportional frequency of pseudomonas infection from 21% to 15%. CONCLUSION: The comparison between the two time periods demonstrates that an aggressive approach to managing intravascular catheters and urinary catheters and limiting the use of antibiotics probably affects the spectrum of nosocomial infections.
Assuntos
Procedimentos Cirúrgicos Cardiovasculares/efeitos adversos , Infecção Hospitalar/epidemiologia , Infecção Hospitalar/etiologia , Unidades de Terapia Intensiva Pediátrica/estatística & dados numéricos , Infecção da Ferida Cirúrgica/epidemiologia , Infecção da Ferida Cirúrgica/etiologia , Procedimentos Cirúrgicos Cardiovasculares/normas , Criança , Infecção Hospitalar/prevenção & controle , Feminino , Hospitais Pediátricos , Humanos , Unidades de Terapia Intensiva Pediátrica/normas , Masculino , Ontário/epidemiologia , Estudos Prospectivos , Controle de Qualidade , Fatores de Risco , Sensibilidade e Especificidade , Infecção da Ferida Cirúrgica/prevenção & controleRESUMO
OBJECTIVES: To describe a severe adverse reaction in a child who received an infusion of propofol for sedation in the intensive care unit (ICU). To describe the management and further investigation of this patient and review similar published reports. DESIGN: Case report and literature review. SETTING: Community hospital ICU and tertiary pediatric ICU. PATIENT: Infant with upper respiratory obstruction secondary to an esophageal foreign body who required tracheal intubation and mechanical ventilation. INTERVENTIONS: Conventional cardiovascular and respiratory support. Continuous veno-venous hemofiltration (CVVH) and plasmapheresis. MEASUREMENTS AND MAIN RESULTS: The patient received a propofol infusion at a mean rate of 10 mg/kg/hr for 50.5 hrs. He developed lipemia and green urine and subsequently, a progressive severe lactic acidemia and bradyarrhythmias unresponsive to conventional treatment. These abnormalities resolved with CVVH. He was encephalopathic and developed liver and muscle necrosis histologically compatible with a toxic insult. Examination of homogenized muscle tissue demonstrated a reduction in cytochrome C oxidase activity. There was no evidence of systemic infection or underlying metabolic disease. He eventually recovered completely. CONCLUSION: Propofol has been associated with severe adverse reactions in children receiving intensive care. The biochemical and histologic abnormalities described in this patient may guide further investigation. We advise against prolonged use of propofol for sedation in children.
Assuntos
Acidose Láctica/induzido quimicamente , Bradicardia/induzido quimicamente , Sedação Consciente/efeitos adversos , Hipnóticos e Sedativos/efeitos adversos , Propofol/efeitos adversos , Acidose Láctica/diagnóstico , Acidose Láctica/metabolismo , Bradicardia/diagnóstico , Bradicardia/metabolismo , Fígado Gorduroso/induzido quimicamente , Fígado Gorduroso/patologia , Humanos , Hiperlipidemias/induzido quimicamente , Lactente , Infusões Intravenosas , Masculino , Doenças Musculares/induzido quimicamente , Doenças Musculares/patologia , Necrose , Oligúria/induzido quimicamente , Respiração ArtificialRESUMO
Current ventilator strategies aim at maintaining an open lung and limiting both peak inspiratory pressures and tidal volumes to avoid alveolar distension. Perfluorocarbons, as well as being excellent solvents for oxygen and carbon dioxide, have the unique properties of being able to recruit dependent lung regions and improve pulmonary mechanics. Optimal ventilator strategies for partial liquid ventilation (PLV) have not yet been clearly defined. In the surfactant-depleted rabbit model, an approach involving a large tidal volume (VT) (15 ml/kg) and lung filled to FRC with perfluorocarbon (PFC) was compared with strategies involving a moderate VT (9 ml/kg) and partially filled lung (6 ml/kg), a moderate VT (9 ml/kg) and lung filled to FRC with PFC, and a large VT (15 ml/kg) and partially filled lung (6 ml/kg). PEEP was maintained at 5 cm H2O except in the moderate VT, partial-filling group, in which a PEEP of 9 cm H2O was used to maintain the rabbits for the duration of the experiment. Oxygenation was satisfactory in all groups, and peak inspiratory pressures were not significantly different. However, five of the 13 animals in the large-VT, PFC-filled lung group died of a pneumothorax prior to completion of the experiment. Of the eight animals in this group surviving the experiment, two had radiographic evidence of pneumothoraces, with an additional three animals having autopsy evidence of air leak. Of the 22 animals in the other groups, all survived with the exception of a single rabbit in the large VT, partial-filling group, which had both radiographic and autopsy evidence of air leak. We conclude that there is a significant risk of barotrauma in a PLV strategy in which a large VT is used in association with a lung filled to FRC with perfluorocarbon. Adequate gas exchange can be achieved with alternative ventilation strategies in combination with PLV.
Assuntos
Barotrauma/etiologia , Fluorocarbonos , Lesão Pulmonar , Pneumotórax/etiologia , Respiração com Pressão Positiva/efeitos adversos , Respiração com Pressão Positiva/métodos , Volume de Ventilação Pulmonar , Animais , Barotrauma/diagnóstico por imagem , Modelos Animais de Doenças , Capacidade Residual Funcional , Masculino , Pneumotórax/diagnóstico por imagem , Troca Gasosa Pulmonar , Coelhos , Radiografia , Mecânica RespiratóriaRESUMO
A complex vascular abnormality in the lungs, termed alveolar capillary dysplasia (ACD) and misalignment of the lung vessels, has been recently recognized in some infants with persistent pulmonary hypertension. These infants die despite maximal medical support including extracorporeal membrane oxygenation (ECMO). Inhaled nitric oxide has been reported to improve oxygenation in neonates with persistent pulmonary hypertension of the newborn, and may allow some infants to avoid the need for ECMO. We identified five infants who had received inhaled nitric oxide to treat refractory hypoxemia caused by persistent pulmonary hypertension of the newborn, and who subsequently died and had autopsy confirmation of ACD. Each infant received care at a different medical center. In each patient, inhaled NO increased the arterial partial pressure of oxygen dramatically. Despite initial clinical improvement, the response to NO was not sustained in any patient. As responsiveness was lost, each infant with ACD required inhaled NO concentrations of 80 ppm or higher to sustain oxygenation. Each infant died, four after extensive periods of ECMO support. This experience demonstrates that a short-term improvement after inhalation of nitric oxide does not lead to long-term survival in ACD. Further, in three infants the diagnosis of ACD was established by lung biopsy before death. Increasing awareness of this clinical entity may allow for the avoidance of costly, invasive procedures such as ECMO until more specific therapies become available.
Assuntos
Óxido Nítrico/uso terapêutico , Síndrome da Persistência do Padrão de Circulação Fetal/terapia , Alvéolos Pulmonares/irrigação sanguínea , Administração por Inalação , Capilares/anormalidades , Oxigenação por Membrana Extracorpórea , Feminino , Humanos , Hipóxia/terapia , Recém-Nascido , Pulmão/patologia , Masculino , Óxido Nítrico/administração & dosagem , Oxigênio/sangue , Síndrome da Persistência do Padrão de Circulação Fetal/etiologia , Síndrome da Persistência do Padrão de Circulação Fetal/mortalidade , Síndrome da Persistência do Padrão de Circulação Fetal/patologia , Fatores de TempoRESUMO
Alveolar capillary dysplasia, a rare cause of neonatal pulmonary hypertension characterized by a developmental abnormality in the pulmonary vasculature, was diagnosed by lung biopsy in a male newborn maintained on nitric oxide therapy for 18 days. Autopsy confirmed the pulmonary vascular defect and demonstrated deficient airspace formation. In addition, a bronchial generation count was low, suggesting that the abnormal lung vascular development in this condition represents a special form of pulmonary hypoplasia that starts in early fetal life.
Assuntos
Pulmão/patologia , Óxido Nítrico/uso terapêutico , Alvéolos Pulmonares/irrigação sanguínea , Biópsia , Brônquios/patologia , Cadáver , Capilares/anormalidades , Humanos , Recém-Nascido , Pulmão/anormalidades , MasculinoRESUMO
BACKGROUND: Among adults who have a cardiac arrest outside the hospital, the survival rate is known to be poor. However, less information is available on out-of-hospital cardiac arrest among children. This study was performed to determine the survival rate among children after out-of-hospital cardiac arrest and to identify predictors of survival. METHODS: We reviewed the records of 101 children (median age, two years) with apnea or no palpable pulse (or both) who presented to the emergency department at the Hospital for Sick Children in Toronto. The characteristics of the patients and the outcomes of illness were analyzed. We assessed the functional outcome of the survivors using the Pediatric Cerebral and Overall Performance Category scores. RESULTS: Overall, there was a return of vital signs in 64 of the 101 patients; 15 survived to discharge from the hospital, and 13 were alive 12 months after discharge. Factors that predicted survival to hospital discharge included a short interval between the arrest and arrival at the hospital, a palpable pulse on presentation, a short duration of resuscitation in the emergency department, and the administration of fewer doses of epinephrine in the emergency department. No patients who required more than two doses of epinephrine or resuscitation for longer than 20 minutes in the emergency department survived to hospital discharge. The survivors who were neurologically normal after arrest had had a respiratory arrest only and were resuscitated within five minutes after arrival in the emergency department. Of the 80 patients who had had a cardiac arrest, only 6 survived to hospital discharge, and all had neurologic sequelae. CONCLUSIONS: These results suggest that out-of-hospital cardiac arrest among children has a very poor prognosis, especially when efforts at resuscitation continue for longer than 20 minutes and require more than two doses of epinephrine.
Assuntos
Reanimação Cardiopulmonar , Parada Cardíaca/mortalidade , Avaliação de Resultados em Cuidados de Saúde , Insuficiência Respiratória/mortalidade , Adolescente , Criança , Pré-Escolar , Serviços Médicos de Emergência , Epinefrina/uso terapêutico , Parada Cardíaca/terapia , Humanos , Lactente , Modelos Logísticos , Insuficiência Respiratória/terapia , Taxa de Sobrevida , Fatores de TempoRESUMO
The purpose of this study was to evaluate prospectively short-latency somatosensory evoked potentials (SEPs) as a predictor of outcome in acute, severe brain injury, and to compare this with the predictive power of the motor component of the Glasgow Coma Scale score and computed tomographic scan. Outcome was measured with the Glasgow Outcome Scale at a minimum of 6 months after injury. We studied 109 patients (aged 0.1 to 16.8 years) with SEPs within 4 days of the onset of coma. Four patients had absent SEPs and a favorable outcome by the Glasgow Outcome Scale (full recovery or moderate disability); two of these patients had meningitis with bilateral subdural effusions, one had a midbrain hemorrhage, and one had a decompressive craniectomy for uncontrolled intracranial hypertension. Normal SEPs had a positive predictive value for favorable outcome of 93% (95% confidence interval (CI), 77% to 99%), and absent SEPs had a positive predictive value for unfavorable outcome by the Glasgow Outcome Scale (severe disability, survival in a persistent vegetative state, or death) of 92% (95% CI, 80% to 98%). If the above identifiable clinical situations in which a physical barrier existed to impede cutaneous reception of the electrical impulse were excluded, the positive predictive value of absent SEPs for poor outcome reached 100% (95% CI, 92% to 100%). An absent motor response to painful stimulus also had 100% positive predictive value (95% CI, 84% to 100%) for unfavorable outcome; however, 23% of patients could not be evaluated because of the effects of muscle relaxants or sedatives. In patients with traumatic brain injury, results of computed tomography did not reliably predict outcome. Of the 59 patients with unfavorable outcome, 76% could be identified with SEPs compared with 36% with examination of motor function. We suggest that SEPs be performed in children with acute severe brain injury because they add an important tool to the physician's prognostic armamentarium. We conclude that in the absence of the above mentioned identifiable clinical situations, absent SEPs predict 100% unfavorable outcome, and this finding may warrant consideration of withdrawal of treatment in children with brain injuries.
Assuntos
Lesões Encefálicas/diagnóstico , Potenciais Somatossensoriais Evocados , Doença Aguda , Adolescente , Lesões Encefálicas/fisiopatologia , Criança , Pré-Escolar , Escala de Coma de Glasgow , Humanos , Lactente , Recém-Nascido , Prognóstico , Estudos Prospectivos , Tomografia Computadorizada por Raios XRESUMO
Twenty-eight ventilated paediatric intensive care patients, mean age 4.1 +/- 4 years, who had had a simple method of nonbronchoscopic bronchoalveolar lavage (NB-BAL) performed were reviewed. The NB-BAL technique involved blindly wedging a 5 or 8F infant feeding catheter endobronchially and lavaging one millilitre per kg saline using a syringe. Adequate samples were collected in 87% of the NB-BAL specimens. In two of the four inadequate specimens, Pneumocystis carinii was still able to be identified. Additional information not obtained from the tracheal aspirate culture was seen in 71% of the NB-BAL samples. One-third of the patients also had a bronchoscopic BAL or a lung biopsy performed and the culture results were all identical to those obtained from NB-BAL. No significant complications were seen. Oxygenation and ventilation were not altered by the technique. We conclude that NB-BAL performed using a syringe and infant feeding catheter is a simple and cheap method that produces good alveolar samples in the majority of cases.
Assuntos
Líquido da Lavagem Broncoalveolar/microbiologia , Pulmão/microbiologia , Adolescente , Bactérias/isolamento & purificação , Cateterismo/instrumentação , Criança , Pré-Escolar , Humanos , Lactente , Recém-Nascido , Intubação/instrumentação , Pulmão/metabolismo , Consumo de Oxigênio , Pneumocystis/isolamento & purificação , Seringas , Irrigação Terapêutica/instrumentação , Irrigação Terapêutica/métodos , Vírus/isolamento & purificaçãoRESUMO
Disruption of the mitral valve following blunt thoracic trauma has been only occasionally reported. A case of a pediatric patient with this complication is presented and the value of transesophageal echocardiography in diagnosis and management is documented.
Assuntos
Ecocardiografia Transesofagiana/métodos , Traumatismos Cardíacos/diagnóstico por imagem , Valva Mitral/diagnóstico por imagem , Valva Mitral/lesões , Ferimentos não Penetrantes/diagnóstico por imagem , Acidentes de Trânsito , Criança , Insuficiência Cardíaca/etiologia , Traumatismos Cardíacos/complicações , Traumatismos Cardíacos/etiologia , Traumatismos Cardíacos/cirurgia , Humanos , Masculino , Ruptura , Ferimentos não Penetrantes/complicações , Ferimentos não Penetrantes/etiologia , Ferimentos não Penetrantes/cirurgiaAssuntos
Crupe/terapia , Epiglotite/terapia , Intubação Intratraqueal , Obstrução das Vias Respiratórias/etiologia , Obstrução das Vias Respiratórias/terapia , Resistência das Vias Respiratórias , Criança , Crupe/diagnóstico , Crupe/etiologia , Diagnóstico Diferencial , Epiglotite/diagnóstico , Epiglotite/etiologia , Humanos , Lactente , TraqueíteRESUMO
Three unrelated female term infants died when less than 1 month old from intractable pulmonary hypertension associated with deficient capillaries in airspace walls, anomalous small pulmonary veins in bronchiolar-arterial rays, and medial thickening in small pulmonary arteries together with peripheral muscularization. This complex vascular abnormality in the lungs has been termed alveolar capillary dysplasia and/or misalignment of lung vessels in seven previously reported cases. Each infant also showed abnormally immature parenchymal development in the lungs, as was noted in four of the seven prior cases. One had phocomelia; four of the seven prior cases had a variety of congenital anomalies. The primary pulmonary vascular anomaly is likely to be a failure of fetal lung vascularization dating from the second trimester and to be due to action of an unknown teratogen. Centroacinar veins may represent bronchial veins that do not normally develop beyond the ends of cartilaginous bronchi. Pulmonary arterial occlusive changes are interpreted as reactive to obstruction at the level of pulmonary arterioles.