Conditional deviant repetition in the oddball paradigm modulates processing at the level of P3a but not MMN.

The auditory system has an amazing ability to rapidly encode auditory regularities. Evidence comes from the popular oddball paradigm, in which frequent (standard) sounds are occasionally exchanged for rare deviant sounds, which then elicit signs of prediction error based on their unexpectedness (e.g., MMN and P3a). Here, we examine the widely neglected characteristics of deviants being bearers of predictive information themselves; naive participants listened to sound sequences constructed according to a new, modified version of the oddball paradigm including two types of deviants that followed diametrically opposed rules: one deviant sound occurred mostly in pairs (repetition rule), the other deviant sound occurred mostly in isolation (non-repetition rule). Due to this manipulation, the sound following a first deviant (either the same deviant or a standard) was either predictable or unpredictable based on its conditional probability associated with the preceding deviant sound. Our behavioral results from an active deviant detection task replicate previous findings that deviant repetition rules (based on conditional probability) can be extracted when behaviorally relevant. Our electrophysiological findings obtained in a passive listening setting indicate that conditional probability also translates into differential processing at the P3a level. However, MMN was confined to global deviants and was not sensitive to conditional probability. This suggests that higher-level processing concerned with stimulus selection and/or evaluation (reflected in P3a) but not lower-level sensory processing (reflected in MMN) considers rarely encountered rules.

Markov chains as a proxy for the predictive memory representations underlying mismatch negativity.

Events not conforming to a regularity inherent to a sequence of events elicit prediction error signals of the brain such as the Mismatch Negativity (MMN) and impair behavioral task performance. Events conforming to a regularity lead to attenuation of brain activity such as stimulus-specific adaptation (SSA) and behavioral benefits. Such findings are usually explained by theories stating that the information processing system predicts the forthcoming event of the sequence via detected sequential regularities. A mathematical model that is widely used to describe, to analyze and to generate event sequences are Markov chains: They contain a set of possible events and a set of probabilities for transitions between these events (transition matrix) that allow to predict the next event on the basis of the current event and the transition probabilities. The accuracy of such a prediction depends on the distribution of the transition probabilities. We argue that Markov chains also have useful applications when studying cognitive brain functions. The transition matrix can be regarded as a proxy for generative memory representations that the brain uses to predict the next event. We assume that detected regularities in a sequence of events correspond to (a subset of) the entries in the transition matrix. We apply this idea to the Mismatch Negativity (MMN) research and examine three types of MMN paradigms: classical oddball paradigms emphasizing sound probabilities, between-sound regularity paradigms manipulating transition probabilities between adjacent sounds, and action-sound coupling paradigms in which sounds are associated with actions and their intended effects. We show that the Markovian view on MMN yields theoretically relevant insights into the brain processes underlying MMN and stimulates experimental designs to study the brain's processing of event sequences.

Deviants violating higher-order auditory regularities can become predictive and facilitate behaviour.

The human auditory system is believed to represent regularities inherent in auditory information in internal models. Sounds not matching the standard regularity (deviants) elicit prediction error, alerting the system to information not explainable within currently active models. Here, we examine the widely neglected characteristic of deviants bearing predictive information themselves. In a modified version of the oddball paradigm, using higher-order regularities, we set up different expectations regarding the sound following a deviant. Higher-order regularities were defined by the relation of pitch within tone pairs (rather than absolute pitch of individual tones). In a deviant detection task participants listened to oddball sequences including two deviant types following diametrically opposed rules: one occurred mostly in succession (high repetition probability) and the other mostly in isolation (low repetition probability). Participants in Experiment 1 were not informed (naïve), whereas in Experiment 2 they were made aware of the repetition rules. Response times significantly decreased from first to second deviant when repetition probability was high-albeit more in the presence of explicit rule knowledge. There was no evidence of a facilitation effect when repetition probability was low. Significantly more false alarms occurred in response to standards following high compared with low repetition probability deviants, but only in participants aware of the repetition rules. These findings provide evidence that not only deviants violating lower- but also higher-order regularities can inform predictions about auditory events. More generally, they confirm the utility of this new paradigm to gather further insights into the predictive properties of the human brain.

Change detection of auditory tonal patterns defined by absolute versus relative pitch information. A combined behavioural and EEG study.

The human auditory system often relies on relative pitch information to extract and identify auditory objects; such as when the same melody is played in different keys. The current study investigated the mental chronometry underlying the active discrimination of unfamiliar melodic six-tone patterns by measuring behavioural performance and event-related potentials (ERPs). In a roving standard paradigm, such patterns were either repeated identically within a stimulus train, carrying absolute frequency information about the pattern, or shifted in pitch (transposed) between repetitions, so only relative pitch information was available to extract the pattern identity. Results showed that participants were able to use relative pitch to detect when a new melodic pattern occurred. Though in the absence of absolute pitch sensitivity significantly decreased and behavioural reaction time to pattern changes increased. Mismatch-Negativity (MMN), an ERP indicator of auditory deviance detection, was elicited at approximately 206 ms after stimulus onset at frontocentral electrodes, even when only relative pitch was available to inform pattern discrimination. A P3a was elicited in both conditions, comparable in amplitude and latency. Increased latencies but no differences in amplitudes of N2b, and P3b suggest that processing at higher levels is affected when, in the absence of absolute pitch cues, relative pitch has to be extracted to inform pattern discrimination. Interestingly, the response delay of approximately 70 ms on the behavioural level, already fully manifests at the level of N2b. This is in accordance with recent findings on implicit auditory learning processes and suggests that in the absence of absolute pitch cues a slowing of target selection rather than a slowing of the auditory pattern change detection process causes the deterioration in behavioural performance.