Right ventricular support for off-pump coronary artery bypass grafting studied with bi-ventricular pressure--volume loops in sheep.

OBJECTIVES: Tilting the heart during off-pump coronary artery bypass grafting (OPCABG) causes a strong decrease in cardiac output. It is hypothesized that this decrease is caused by reduced right ventricular filling and that right ventricular support is thus the best way to restore cardiac output. Simultaneous left and right ventricular pressure-volume loops were used to test this hypothesis. METHODS: In seven sheep, the heart was tilted with the use of an Octopus device. After unsupported tilting, a novel right ventricular support, the Enabler, was activated at a pulsatile flow of 1.6 l/min. Pressure-volume loops of both ventricles were obtained using conductance catheters, and cardiac output was monitored with an aortic flow probe. RESULTS: Tilting reduced cardiac output by 31% (4.4--3.1 l/min, P=0.001) and right ventricular end-diastolic volume by 44% (86--51 ml, P=0.005), while right ventricular end-diastolic pressure did not decrease. Left ventricular systolic pressure was not significantly reduced upon tilting and even increased in two animals. During Enabler right ventricular support, the cardiac output remained 23% lower than pre-tilting values (3.4 vs. 4.4 l/min, P=0.001). CONCLUSIONS: Restricted right ventricular filling is the primary cause of the strong decrease in cardiac output during tilting. The Enabler right ventricular support can currently not restore cardiac output to pre-tilting values, mainly caused by its limited output and a decrease in right ventricular output upon Enabler activation. Constant monitoring of cardiac output is crucial during (unsupported or supported) tilting as blood pressure alone may not reflect the extent of the reduction in cardiac function.

The enabler right ventricular circulatory support system for beating heart coronary artery bypass graft surgery.

BACKGROUND: Beating heart coronary artery bypass graft surgery of the left anterior descending, diagonal, and right coronary artery can be performed safely with the Octopus Stabilization System. However, tilting of the heart, which is necessary to reach the obtuse marginal and distal right coronary arteries, causes hemodynamic instability. This study was performed to investigate the possible role of the Enabler right ventricular circulatory support system in counteracting this instability. METHODS: In 8 sheep, the Enabler cannula was introduced via the jugular vein and positioned with the inlet valve in the right atrium and outlet valve in the pulmonary artery. The Octopus was used to expose the inferior wall and the posterior wall of the left ventricle. The hemodynamic effects of this tilting with and without Enabler right ventricular support were recorded, including Pressure Volume (PV) loops measured by conductance catheters in both ventricles. RESULTS: Tilting caused a reduction in stroke volume (inferior 31%, posterior 17%) and Enabler activation increased stroke volume (inferior 13%, posterior 31%). CONCLUSIONS: Tilting the heart has severe hemodynamic consequences that can be partially counteracted by the use of the Enabler for right ventricle support.