[ATP effects on eccito-conduction and arterial pressure before and after block of the vagus. Haemodynamic and electrophysiologic study (author's transl)]. / L'azione dell'ATP sull'eccito-conduzione e sulla P.A. prima e dopo blocco del vago. Studio elettrofisiologico ed emodinamico.

In order to investigate the cardiovascular effects of ATP (15-30 mg) i.v. administration, 12 normal subjects, aged 27-55 yrs, were studied, during Arterial Pressure Monitoring and His Bundle Electrogram recording, using Sherlag's technique. ATP cardiovascular response was divided in the following four phases: Latency phase, Progressive Bra dyarrhythmic-Hypotensive, Maximal Inhibitor Phase, Tachyarrhytthmic Hypotensive Reflex Phase. Atropine (0.02-0.04 mg/Kg) i.v. injection did not significantly prevent ATP effects. Increasing dosage of atropine (0,06, pointed out a moderate competitive antagonism with ATP. These data suggest a possible direct action of ATP (purinergic receptors or direct membrane effect) but don't exclude an interaction with Parasympathetic system (probable purinergic neuromodulation).

[Transient left posterior hemiblock in acute ischemic cardiopathy]. / Hémibloc postérieur gauche transitoire dans la cardiopathie ischémique aiguë

Report of seven cases of intermittent left posterior hemiblock in subjects with acute ischaemic heart disease. The electrocardiograms of all the patients (together with the coronary arteriography in three cases) have shown the presence of two different areas of ischaemia: the anterior wall and the diaphragmatic wall of the left ventricle. In three patients acute coronary ischaemia was present in both areas; in the other cases one myocardial wall only was involved.