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1.
Biosensors (Basel) ; 12(7)2022 Jul 11.
Artigo em Inglês | MEDLINE | ID: mdl-35884312

RESUMO

Appropriate teaching-learning strategies lead to student engagement during learning activities. Scientific progress and modern technology have made it possible to measure engagement in educational settings by reading and analyzing student physiological signals through sensors attached to wearables. This work is a review of current student engagement detection initiatives in the educational domain. The review highlights existing commercial and non-commercial wearables for student engagement monitoring and identifies key physiological signals involved in engagement detection. Our findings reveal that common physiological signals used to measure student engagement include heart rate, skin temperature, respiratory rate, oxygen saturation, blood pressure, and electrocardiogram (ECG) data. Similarly, stress and surprise are key features of student engagement.


Assuntos
Dispositivos Eletrônicos Vestíveis , Humanos
2.
Rev. esp. enferm. dig ; 110(6): 372-379, jun. 2018. tab, graf
Artigo em Inglês | IBECS | ID: ibc-177691

RESUMO

Background and aim: the aim of the study was to use a validated questionnaire to identify factors associated with the development of gastric cancer (GC) in the Mexican population. Methods: the study included cases and controls that were paired by sex and ± 10 years of age at diagnosis. In relation to cases, 46 patients with a confirmed histopathological diagnosis of adenocarcinoma-type GC, as reported in the hospital records, were selected, and 46 blood bank donors from the same hospital were included as controls. The previously validated Questionnaire to Find Factors Associated with Gastric Cancer (QUFA-GC(c)) was used to collect data. Odds ratio (OR) and 95% confidence interval (IC) were estimated via univariate analysis (paired OR). Multivariate analysis was performed by logistic regression. A decision tree was constructed using the J48 algorithm. Results: an association was found by univariate analysis between GC risk and a lack of formal education, having smoked for ≥ 10 years, eating rapidly, consuming very hot food and drinks, a non-suitable breakfast within two hours of waking, pickled food and capsaicin. In contrast, a protective association against GC was found with taking recreational exercise and consuming fresh fruit and vegetables. No association was found between the development of GC and having an income that reflected poverty, using a refrigerator, perception of the omission of breakfast and time period of alcoholism. In the final multivariate analysis model, having no formal education (OR = 17.47, 95% CI = 5.17-76.69), consuming a non-suitable breakfast within two hours of waking (OR = 8.99, 95% CI = 2.85-35.50) and the consumption of capsaicin ˃ 29.9 mg capsaicin per day (OR = 3.77, 95% CI = 1.21-13.11) were factors associated with GC. Conclusions: an association was found by multivariate analysis between the presence of GC and education, type of breakfast and the consumption of capsaicin. These variables are susceptible to intervention and can be identified via the QUFA-GC(c)


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Assuntos
Humanos , Neoplasias Gástricas/epidemiologia , Infecções por Helicobacter/epidemiologia , Capsaicina/farmacocinética , Fatores de Risco , Neoplasias Gástricas/etiologia , México/epidemiologia , Escolaridade , Capsicum/efeitos adversos , Jejum/efeitos adversos , Tabagismo/epidemiologia
3.
Rev Esp Enferm Dig ; 110(6): 372-379, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29843516

RESUMO

BACKGROUND AND AIM: the aim of the study was to use a validated questionnaire to identify factors associated with the development of gastric cancer (GC) in the Mexican population. METHODS: the study included cases and controls that were paired by sex and ± 10 years of age at diagnosis. In relation to cases, 46 patients with a confirmed histopathological diagnosis of adenocarcinoma-type GC, as reported in the hospital records, were selected, and 46 blood bank donors from the same hospital were included as controls. The previously validated Questionnaire to Find Factors Associated with Gastric Cancer (QUFA-GC©) was used to collect data. Odds ratio (OR) and 95% confidence interval (IC) were estimated via univariate analysis (paired OR). Multivariate analysis was performed by logistic regression. A decision tree was constructed using the J48 algorithm. RESULTS: an association was found by univariate analysis between GC risk and a lack of formal education, having smoked for ≥ 10 years, eating rapidly, consuming very hot food and drinks, a non-suitable breakfast within two hours of waking, pickled food and capsaicin. In contrast, a protective association against GC was found with taking recreational exercise and consuming fresh fruit and vegetables. No association was found between the development of GC and having an income that reflected poverty, using a refrigerator, perception of the omission of breakfast and time period of alcoholism. In the final multivariate analysis model, having no formal education (OR = 17.47, 95% CI = 5.17-76.69), consuming a non-suitable breakfast within two hours of waking (OR = 8.99, 95% CI = 2.85-35.50) and the consumption of capsaicin ˃ 29.9 mg capsaicin per day (OR = 3.77, 95% CI = 1.21-13.11) were factors associated with GC. CONCLUSIONS: an association was found by multivariate analysis between the presence of GC and education, type of breakfast and the consumption of capsaicin. These variables are susceptible to intervention and can be identified via the QUFA-GC


Assuntos
Adenocarcinoma/etiologia , Neoplasias Gástricas/etiologia , Adulto , Idoso , Desjejum , Capsaicina/efeitos adversos , Estudos de Casos e Controles , Dieta/efeitos adversos , Escolaridade , Feminino , Humanos , Modelos Logísticos , Masculino , México , Pessoa de Meia-Idade , Análise Multivariada , Estudos Retrospectivos , Fatores de Risco , Inquéritos e Questionários
4.
Comput Math Methods Med ; 2017: 5989105, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28744318

RESUMO

Efforts have been being made to improve the diagnostic performance of colposcopy, trying to help better diagnose cervical cancer, particularly in developing countries. However, improvements in a number of areas are still necessary, such as the time it takes to process the full digital image of the cervix, the performance of the computing systems used to identify different kinds of tissues, and biopsy sampling. In this paper, we explore three different, well-known automatic classification methods (k-Nearest Neighbors, Naïve Bayes, and C4.5), in addition to different data models that take full advantage of this information and improve the diagnostic performance of colposcopy based on acetowhite temporal patterns. Based on the ROC and PRC area scores, the k-Nearest Neighbors and discrete PLA representation performed better than other methods. The values of sensitivity, specificity, and accuracy reached using this method were 60% (95% CI 50-70), 79% (95% CI 71-86), and 70% (95% CI 60-80), respectively. The acetowhitening phenomenon is not exclusive to high-grade lesions, and we have found acetowhite temporal patterns of epithelial changes that are not precancerous lesions but that are similar to positive ones. These findings need to be considered when developing more robust computing systems in the future.


Assuntos
Colposcopia/normas , Modelos Estatísticos , Displasia do Colo do Útero/diagnóstico , Neoplasias do Colo do Útero/diagnóstico , Teorema de Bayes , Colo do Útero/diagnóstico por imagem , Feminino , Humanos , Gravidez , Sensibilidade e Especificidade
5.
J Theor Biol ; 357: 21-5, 2014 Sep 21.
Artigo em Inglês | MEDLINE | ID: mdl-24819465

RESUMO

BACKGROUND: Alzheimer's disease (AD) is characterized by a gradual loss of memory, orientation, judgement and language. There is still no cure for this disorder. AD pathogenesis remains fairly unknown and its underlying molecular mechanisms are not yet fully understood. Several studies have shown that the abnormal accumulation of beta-amyloid and tau proteins occurs 10 to 20 years before the onset of symptoms of the disease, so it is extremely important to identify changes in the brain before the first symptoms. METHODS: We used decision trees to classify 31 individuals (9 healthy controls and 22 AD patients in three different stages of disease) according to the expression of 69 genes previously reported in a meta-analysis, plus the expression levels of APP, APOE, BACE1, NCSTN, PSEN1, PSEN2 and MAPT. We also included in our analysis the MMSE (Mini-Mental State Examination) scores and number of NFT (neurofibrillary tangles). RESULTS: Results allowed us to generate a model of classification values for different AD stages of severity, according to MMSE scores, and achieve the identification of the expression level of protein tau that may possibly determine the onset (incipient stage) of AD. DISCUSSION: We used decision trees to model the different stages of AD (severe, moderate, incipient and control) based on the meta-analysis of gene expression levels plus MMSE and NFT scores. Both classifiers reported the variable MMSE as most informative, however it we were found that the protein tau also an important role in the onset of AD.


Assuntos
Doença de Alzheimer , Peptídeos beta-Amiloides , Regulação da Expressão Gênica , Modelos Biológicos , Proteínas tau , Doença de Alzheimer/genética , Doença de Alzheimer/metabolismo , Doença de Alzheimer/patologia , Peptídeos beta-Amiloides/biossíntese , Humanos , Proteínas tau/biossíntese
6.
J Biomed Inform ; 49: 73-83, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24637143

RESUMO

In this work, we present a novel application of time series discretization using evolutionary programming for the classification of precancerous cervical lesions. The approach optimizes the number of intervals in which the length and amplitude of the time series should be compressed, preserving the important information for classification purposes. Using evolutionary programming, the search for a good discretization scheme is guided by a cost function which considers three criteria: the entropy regarding the classification, the complexity measured as the number of different strings needed to represent the complete data set, and the compression rate assessed as the length of the discrete representation. This discretization approach is evaluated using a time series data based on temporal patterns observed during a classical test used in cervical cancer detection; the classification accuracy reached by our method is compared with the well-known times series discretization algorithm SAX and the dimensionality reduction method PCA. Statistical analysis of the classification accuracy shows that the discrete representation is as efficient as the complete raw representation for the present application, reducing the dimensionality of the time series length by 97%. This representation is also very competitive in terms of classification accuracy when compared with similar approaches.


Assuntos
Lesões Pré-Cancerosas/classificação , Neoplasias do Colo do Útero/classificação , Feminino , Humanos , Análise de Componente Principal
7.
PLoS One ; 9(3): e92866, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24671204

RESUMO

The bias-variance dilemma is a well-known and important problem in Machine Learning. It basically relates the generalization capability (goodness of fit) of a learning method to its corresponding complexity. When we have enough data at hand, it is possible to use these data in such a way so as to minimize overfitting (the risk of selecting a complex model that generalizes poorly). Unfortunately, there are many situations where we simply do not have this required amount of data. Thus, we need to find methods capable of efficiently exploiting the available data while avoiding overfitting. Different metrics have been proposed to achieve this goal: the Minimum Description Length principle (MDL), Akaike's Information Criterion (AIC) and Bayesian Information Criterion (BIC), among others. In this paper, we focus on crude MDL and empirically evaluate its performance in selecting models with a good balance between goodness of fit and complexity: the so-called bias-variance dilemma, decomposition or tradeoff. Although the graphical interaction between these dimensions (bias and variance) is ubiquitous in the Machine Learning literature, few works present experimental evidence to recover such interaction. In our experiments, we argue that the resulting graphs allow us to gain insights that are difficult to unveil otherwise: that crude MDL naturally selects balanced models in terms of bias-variance, which not necessarily need be the gold-standard ones. We carry out these experiments using a specific model: a Bayesian network. In spite of these motivating results, we also should not overlook three other components that may significantly affect the final model selection: the search procedure, the noise rate and the sample size.


Assuntos
Algoritmos , Viés , Teorema de Bayes , Bases de Dados como Assunto , Probabilidade
8.
Comput Math Methods Med ; 2013: 285962, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24174988

RESUMO

A nonrigid body image registration method for spatiotemporal alignment of image sequences obtained from colposcopy examinations to detect precancerous lesions of the cervix is proposed in this paper. The approach is based on time series calculation for those pixels in the first image of the sequence and a division of such image into small windows. A search process is then carried out to find the window with the highest affinity in each image of the sequence and replace it with the window in the reference image. The affinity value is based on polynomial approximation of the time series computed and the search is bounded by a search radius which defines the neighborhood of each window. The proposed approach is tested in ten 310-frame real cases in two experiments: the first one to determine the best values for the window size and the search radius and the second one to compare the best obtained results with respect to four registration methods found in the specialized literature. The obtained results show a robust and competitive performance of the proposed approach with a significant lower time with respect to the compared methods.


Assuntos
Colposcopia/estatística & dados numéricos , Interpretação de Imagem Assistida por Computador/métodos , Feminino , Humanos , Lesões Pré-Cancerosas/diagnóstico , Fatores de Tempo , Neoplasias do Colo do Útero/diagnóstico
9.
Comput Biol Med ; 39(9): 778-84, 2009 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-19608162

RESUMO

After Pap smear test, colposcopy is the most used technique to diagnose cervical cancer due to its higher sensitivity and specificity. One of the most promising approaches to improve the colposcopic test is the use of the aceto-white temporal patterns intrinsic to the color changes in digital images. However, there is not a complete understanding of how to use them to segment colposcopic images. In this work, we used the classification algorithm k-NN over the entire length of the aceto-white temporal pattern to automatically discriminate between normal and abnormal cervical tissue, reaching a sensitivity of 71% and specificity of 59%.


Assuntos
Algoritmos , Colposcopia/estatística & dados numéricos , Diagnóstico por Computador , Lesões Pré-Cancerosas/diagnóstico , Neoplasias do Colo do Útero/diagnóstico , Adulto , Inteligência Artificial , Simulação por Computador , Feminino , Humanos , Interpretação de Imagem Assistida por Computador , México , Projetos Piloto , Lesões Pré-Cancerosas/classificação , Neoplasias do Colo do Útero/classificação , Adulto Jovem
10.
Comput Biol Med ; 37(11): 1553-64, 2007 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-17434159

RESUMO

We evaluate the effectiveness of seven Bayesian network classifiers as potential tools for the diagnosis of breast cancer using two real-world databases containing fine-needle aspiration of the breast lesion cases collected by a single observer and multiple observers, respectively. The results show a certain ingredient of subjectivity implicitly contained in these data: we get an average accuracy of 93.04% for the former and 83.31% for the latter. These findings suggest that observers see different things when looking at the samples in the microscope; a situation that significantly diminishes the performance of these classifiers in diagnosing such a disease.


Assuntos
Neoplasias da Mama/diagnóstico , Diagnóstico por Computador , Algoritmos , Teorema de Bayes , Biópsia por Agulha Fina , Citodiagnóstico/estatística & dados numéricos , Bases de Dados Factuais , Diagnóstico por Computador/estatística & dados numéricos , Feminino , Humanos , Variações Dependentes do Observador
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