1.
Boll Chim Farm
; 134(8): 454-8, 1995 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7576444
RESUMO
Four basic esters of cyclohexancarbamic acid and their salts with hydrochloride were synthesized and evaluated for local anesthetic activity. It was found that also aliphatic carbamates studied exhibit local anesthetic activity comparable with the activity of analogous esters of aromatic (2-methoxyphenyl) carbamic acid. Our comparative investigation shows that the presence of aromatic group in the ester of carbamic acid influences local anesthetic activity, however the occurrence of aromatic moiety is not necessary condition for their activity.