RESUMO
Some uncertainty about deferoxamine ototoxicity is to be found in the literature. Therefore, 100 patients affected by beta-thalassemia were checked audiologically. Twelve of them showed a sensorineural hearing impairment which in most cases was confined to 4 and 8 kHz. If these results are compared with a sample of "normal" population, no significant difference can be observed, therefore excluding that deferoxamine, at least at present dosages, may be considered as a certain cause of cochlear impairment.
Assuntos
Desferroxamina/efeitos adversos , Perda Auditiva Neurossensorial/induzido quimicamente , Talassemia/terapia , Adolescente , Adulto , Criança , Desferroxamina/uso terapêutico , HumanosRESUMO
Glucose-6-phosphate dehydrogenase deficiency, A1A2BO, Rhesus and Kell systems were investigated in a sample of 28,439 blood donors native of northern Sardinia. The frequency of deficient male individuals was 6.56%. Higher values of r, D, and CDe compared to the averages for continental Italy were observed. Variations within the island were found in the A1A2BO and Rhesus blood group systems.
Assuntos
Sistema ABO de Grupos Sanguíneos , Antígenos de Grupos Sanguíneos , Deficiência de Glucosefosfato Desidrogenase/genética , Sistema do Grupo Sanguíneo de Kell , Sistema do Grupo Sanguíneo Rh-Hr , Frequência do Gene , Humanos , Itália , MasculinoRESUMO
We studied serum lipids and lipoproteins in 20 patients with beta-thalassemia major, under high transfusion programme and regular chelation therapy, and in 20 control subjects. Total cholesterol, HDL-cholesterol, HDL2-and HDL3-cholesterol, apolipoprotein A and B levels were significantly lower in patients with Cooley's anemia, whereas free cholesterol, triglycerides and the HDL-/HDL3-cholesterol ratio did not differ in the two groups. We think that liver damage plays an important role in determining the altered lipoprotein pattern in beta-thalassemia major. However, other factors may contribute to cause such lipid changes.
