1.
J Org Chem
; 68(7): 2645-51, 2003 Apr 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12662034
RESUMO
A simple and versatile method for the enantio- and diastereoselective synthesis of mono- or disubstituted 3-aminoazepanes is described. The key step involves a highly regio- and diastereoselective tandem ring-enlargement/alkylation or reduction process. This novel synthetic route provides enantiomerically pure constrained diamines interesting as scaffolds for medicinal chemistry.